A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic Article Swipe

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Fluorescence Isoxazole Chemistry Oxime Selectivity Fluorescein Proton NMR Photochemistry Combinatorial chemistry Stereochemistry Organic chemistry Catalysis Quantum mechanics Physics

Xin Guo , Chang-Xiang Liu , Yuan Lu , Ya‐Wen Wang , Yu Peng ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.3390/molecules27020489 · OA: W4205613548

A novel two-site chemodosimeter (SWJT-4) based on fluorescein skeleton to detect diethyl chlorophosphate (DCP) was designed and synthesized. It is a turn-on fluorescent probe for DCP with good selectivity and obvious color change in aqueous solution. Interestingly, the two oxime groups of SWJT-4 as dual response sites initiated different reactions with DCP to form a cyano group and an isoxazole ring, respectively. The corresponding mechanism was confirmed by 1H NMR, MS and DFT calculation. Moreover, SWJT-4 could be used as a fluorescent test paper to detect DCP vapor.