A drug repurposing screen for whipworms informed by comparative genomics Article Swipe
Avril Coghlan
,
Frederick A. Partridge
,
Maria A. Duque‐Correa
,
Gabriel Rinaldi
,
Simon Clare
,
Lisa Seymour
,
Cordelia Brandt
,
Tapoka T. Mkandawire
,
Catherine McCarthy
,
Nancy Holroyd
,
Marina Nick
,
Anwen E. Brown
,
Sirapat Tonitiwong
,
David B. Sattelle
,
Matthew Berriman
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pntd.0011205
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pntd.0011205
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura . Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for other human diseases could be repurposed as novel anti-whipworm drugs. In a previous comparative genomics analysis, we identified 409 drugs approved for human use that we predicted to target parasitic worm proteins. Here we tested these ex vivo by assessing motility of adult worms of Trichuris muris , the murine whipworm, an established model for human whipworm research. We identified 14 compounds with EC 50 values of ≤ 50 μM against T . muris ex vivo , and selected nine for testing in vivo . However, the best worm burden reduction seen in mice was just 19%. The high number of ex vivo hits against T . muris shows that we were successful at predicting parasite proteins that could be targeted by approved drugs. In contrast, the low efficacy of these compounds in mice suggest challenges due to their chemical properties (e.g. lipophilicity, polarity, molecular weight) and pharmacokinetics (e.g. absorption, distribution, metabolism, and excretion) that may (i) promote absorption by the host gastrointestinal tract, thereby reducing availability to the worms embedded in the large intestine, and/or (ii) restrict drug uptake by the worms. This indicates that identifying structural analogues that have reduced absorption by the host, and increased uptake by worms, may be necessary for successful drug development against whipworms.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pntd.0011205
- OA Status
- gold
- Cited By
- 6
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386453498
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4386453498Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pntd.0011205Digital Object Identifier
- Title
-
A drug repurposing screen for whipworms informed by comparative genomicsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-09-05Full publication date if available
- Authors
-
Avril Coghlan, Frederick A. Partridge, Maria A. Duque‐Correa, Gabriel Rinaldi, Simon Clare, Lisa Seymour, Cordelia Brandt, Tapoka T. Mkandawire, Catherine McCarthy, Nancy Holroyd, Marina Nick, Anwen E. Brown, Sirapat Tonitiwong, David B. Sattelle, Matthew BerrimanList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pntd.0011205Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1371/journal.pntd.0011205Direct OA link when available
- Concepts
-
Repurposing, Drug repositioning, Medicine, Drug, Genomics, Computational biology, Biology, Pharmacology, Genome, Genetics, Gene, EcologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 4Per-year citation counts (last 5 years)
- References (count)
-
54Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4386453498 |
|---|---|
| doi | https://doi.org/10.1371/journal.pntd.0011205 |
| ids.doi | https://doi.org/10.1371/journal.pntd.0011205 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37669291 |
| ids.openalex | https://openalex.org/W4386453498 |
| fwci | 2.20002446 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000328 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Adult |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D006801 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Humans |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000818 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Animals |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D051379 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Mice |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D058492 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Drug Repositioning |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D014258 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | Trichuris |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D023281 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Genomics |
| mesh[7].qualifier_ui | Q000494 |
| mesh[7].descriptor_ui | D015766 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | pharmacology |
| mesh[7].descriptor_name | Albendazole |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D001692 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Biological Transport |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D000328 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Adult |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D006801 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Humans |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D000818 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Animals |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D051379 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Mice |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D058492 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Drug Repositioning |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D014258 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Trichuris |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D023281 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Genomics |
| mesh[16].qualifier_ui | Q000494 |
| mesh[16].descriptor_ui | D015766 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | pharmacology |
| mesh[16].descriptor_name | Albendazole |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D001692 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Biological Transport |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000328 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Adult |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D006801 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Humans |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D000818 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Animals |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D051379 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Mice |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D058492 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Drug Repositioning |
| mesh[23].qualifier_ui | Q000235 |
| mesh[23].descriptor_ui | D014258 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | genetics |
| mesh[23].descriptor_name | Trichuris |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D023281 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Genomics |
| mesh[25].qualifier_ui | Q000494 |
| mesh[25].descriptor_ui | D015766 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | pharmacology |
| mesh[25].descriptor_name | Albendazole |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D001692 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Biological Transport |
| type | article |
| title | A drug repurposing screen for whipworms informed by comparative genomics |
| awards[0].id | https://openalex.org/G7219380808 |
| awards[0].funder_id | https://openalex.org/F4320334626 |
| awards[0].funder_award_id | (CiC6) 2017 MC_PC_17180 |
| awards[0].funder_display_name | Medical Research Council |
| awards[1].id | https://openalex.org/G7549917023 |
| awards[1].funder_id | https://openalex.org/F4320311904 |
| awards[1].funder_award_id | 206194 |
| awards[1].funder_display_name | Wellcome Trust |
| biblio.issue | 9 |
| biblio.volume | 17 |
| biblio.last_page | e0011205 |
| biblio.first_page | e0011205 |
| grants[0].funder | https://openalex.org/F4320311904 |
| grants[0].award_id | 206194 |
| grants[0].funder_display_name | Wellcome Trust |
| grants[1].funder | https://openalex.org/F4320334626 |
| grants[1].award_id | (CiC6) 2017 MC_PC_17180 |
| grants[1].funder_display_name | Medical Research Council |
| topics[0].id | https://openalex.org/T10695 |
| topics[0].field.id | https://openalex.org/fields/24 |
| topics[0].field.display_name | Immunology and Microbiology |
| topics[0].score | 0.9959999918937683 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2405 |
| topics[0].subfield.display_name | Parasitology |
| topics[0].display_name | Parasites and Host Interactions |
| topics[1].id | https://openalex.org/T11074 |
| topics[1].field.id | https://openalex.org/fields/34 |
| topics[1].field.display_name | Veterinary |
| topics[1].score | 0.9477999806404114 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/3404 |
| topics[1].subfield.display_name | Small Animals |
| topics[1].display_name | Helminth infection and control |
| topics[2].id | https://openalex.org/T12492 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9455000162124634 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2739 |
| topics[2].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[2].display_name | Zoonotic diseases and public health |
| funders[0].id | https://openalex.org/F4320311904 |
| funders[0].ror | https://ror.org/029chgv08 |
| funders[0].display_name | Wellcome Trust |
| funders[1].id | https://openalex.org/F4320334626 |
| funders[1].ror | https://ror.org/03x94j517 |
| funders[1].display_name | Medical Research Council |
| is_xpac | False |
| apc_list.value | 2495 |
| apc_list.currency | USD |
| apc_list.value_usd | 2495 |
| apc_paid.value | 2495 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2495 |
| concepts[0].id | https://openalex.org/C519536355 |
| concepts[0].level | 2 |
| concepts[0].score | 0.761457085609436 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q21021151 |
| concepts[0].display_name | Repurposing |
| concepts[1].id | https://openalex.org/C103637391 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7395119071006775 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q5308921 |
| concepts[1].display_name | Drug repositioning |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.4885352551937103 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C2780035454 |
| concepts[3].level | 2 |
| concepts[3].score | 0.4641173481941223 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q8386 |
| concepts[3].display_name | Drug |
| concepts[4].id | https://openalex.org/C189206191 |
| concepts[4].level | 4 |
| concepts[4].score | 0.4179142117500305 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q222046 |
| concepts[4].display_name | Genomics |
| concepts[5].id | https://openalex.org/C70721500 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3848992586135864 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[5].display_name | Computational biology |
| concepts[6].id | https://openalex.org/C86803240 |
| concepts[6].level | 0 |
| concepts[6].score | 0.3253176808357239 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[6].display_name | Biology |
| concepts[7].id | https://openalex.org/C98274493 |
| concepts[7].level | 1 |
| concepts[7].score | 0.26054447889328003 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[7].display_name | Pharmacology |
| concepts[8].id | https://openalex.org/C141231307 |
| concepts[8].level | 3 |
| concepts[8].score | 0.167240709066391 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7020 |
| concepts[8].display_name | Genome |
| concepts[9].id | https://openalex.org/C54355233 |
| concepts[9].level | 1 |
| concepts[9].score | 0.11419203877449036 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[9].display_name | Genetics |
| concepts[10].id | https://openalex.org/C104317684 |
| concepts[10].level | 2 |
| concepts[10].score | 0.0754534900188446 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[10].display_name | Gene |
| concepts[11].id | https://openalex.org/C18903297 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7150 |
| concepts[11].display_name | Ecology |
| keywords[0].id | https://openalex.org/keywords/repurposing |
| keywords[0].score | 0.761457085609436 |
| keywords[0].display_name | Repurposing |
| keywords[1].id | https://openalex.org/keywords/drug-repositioning |
| keywords[1].score | 0.7395119071006775 |
| keywords[1].display_name | Drug repositioning |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.4885352551937103 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/drug |
| keywords[3].score | 0.4641173481941223 |
| keywords[3].display_name | Drug |
| keywords[4].id | https://openalex.org/keywords/genomics |
| keywords[4].score | 0.4179142117500305 |
| keywords[4].display_name | Genomics |
| keywords[5].id | https://openalex.org/keywords/computational-biology |
| keywords[5].score | 0.3848992586135864 |
| keywords[5].display_name | Computational biology |
| keywords[6].id | https://openalex.org/keywords/biology |
| keywords[6].score | 0.3253176808357239 |
| keywords[6].display_name | Biology |
| keywords[7].id | https://openalex.org/keywords/pharmacology |
| keywords[7].score | 0.26054447889328003 |
| keywords[7].display_name | Pharmacology |
| keywords[8].id | https://openalex.org/keywords/genome |
| keywords[8].score | 0.167240709066391 |
| keywords[8].display_name | Genome |
| keywords[9].id | https://openalex.org/keywords/genetics |
| keywords[9].score | 0.11419203877449036 |
| keywords[9].display_name | Genetics |
| keywords[10].id | https://openalex.org/keywords/gene |
| keywords[10].score | 0.0754534900188446 |
| keywords[10].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1371/journal.pntd.0011205 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S46544255 |
| locations[0].source.issn | 1935-2727, 1935-2735 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1935-2727 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | PLoS neglected tropical diseases |
| locations[0].source.host_organization | https://openalex.org/P4310315706 |
| locations[0].source.host_organization_name | Public Library of Science |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315706 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | PLOS Neglected Tropical Diseases |
| locations[0].landing_page_url | https://doi.org/10.1371/journal.pntd.0011205 |
| locations[1].id | pmid:37669291 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | PLoS neglected tropical diseases |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37669291 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10503962 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10503962/pdf/pntd.0011205.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | PLoS Negl Trop Dis |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10503962 |
| locations[3].id | pmh:oai:doaj.org/article:a9399883925e4c239ce6cfe85ef5286d |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011205 (2023) |
| locations[3].landing_page_url | https://doaj.org/article/a9399883925e4c239ce6cfe85ef5286d |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5056001112 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2775-5951 |
| authorships[0].author.display_name | Avril Coghlan |
| authorships[0].countries | GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[0].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[0].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[0].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[0].institutions[0].type | nonprofit |
| authorships[0].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[0].institutions[0].country_code | GB |
| authorships[0].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Avril Coghlan |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[1].author.id | https://openalex.org/A5082664707 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-6236-4297 |
| authorships[1].author.display_name | Frederick A. Partridge |
| authorships[1].countries | GB |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[1].affiliations[0].raw_affiliation_string | University College London, London, United Kingdom |
| authorships[1].institutions[0].id | https://openalex.org/I45129253 |
| authorships[1].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[1].institutions[0].country_code | GB |
| authorships[1].institutions[0].display_name | University College London |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Frederick A. Partridge |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | University College London, London, United Kingdom |
| authorships[2].author.id | https://openalex.org/A5017711874 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-0567-0412 |
| authorships[2].author.display_name | Maria A. Duque‐Correa |
| authorships[2].countries | GB |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[2].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[2].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[2].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[2].institutions[0].type | nonprofit |
| authorships[2].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[2].institutions[0].country_code | GB |
| authorships[2].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | María Adelaida Duque-Correa |
| authorships[2].is_corresponding | True |
| authorships[2].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[3].author.id | https://openalex.org/A5028251855 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-7767-4922 |
| authorships[3].author.display_name | Gabriel Rinaldi |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[3].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[3].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[3].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[3].institutions[0].type | nonprofit |
| authorships[3].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Gabriel Rinaldi |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[4].author.id | https://openalex.org/A5101722036 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-0072-9996 |
| authorships[4].author.display_name | Simon Clare |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[4].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[4].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[4].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[4].institutions[0].type | nonprofit |
| authorships[4].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[4].institutions[0].country_code | GB |
| authorships[4].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Simon Clare |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[5].author.id | https://openalex.org/A5112994725 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Lisa Seymour |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[5].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[5].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[5].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[5].institutions[0].type | nonprofit |
| authorships[5].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Lisa Seymour |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[6].author.id | https://openalex.org/A5040476896 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Cordelia Brandt |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[6].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[6].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[6].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[6].institutions[0].type | nonprofit |
| authorships[6].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Cordelia Brandt |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[7].author.id | https://openalex.org/A5072410641 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-3751-0114 |
| authorships[7].author.display_name | Tapoka T. Mkandawire |
| authorships[7].countries | GB |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[7].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[7].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[7].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[7].institutions[0].type | nonprofit |
| authorships[7].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[7].institutions[0].country_code | GB |
| authorships[7].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Tapoka T. Mkandawire |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[8].author.id | https://openalex.org/A5105938350 |
| authorships[8].author.orcid | https://orcid.org/0009-0009-1803-187X |
| authorships[8].author.display_name | Catherine McCarthy |
| authorships[8].countries | GB |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[8].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[8].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[8].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[8].institutions[0].type | nonprofit |
| authorships[8].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[8].institutions[0].country_code | GB |
| authorships[8].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Catherine McCarthy |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[9].author.id | https://openalex.org/A5011572601 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-2608-7151 |
| authorships[9].author.display_name | Nancy Holroyd |
| authorships[9].countries | GB |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[9].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[9].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[9].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[9].institutions[0].type | nonprofit |
| authorships[9].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[9].institutions[0].country_code | GB |
| authorships[9].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Nancy Holroyd |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[10].author.id | https://openalex.org/A5032015519 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9972-963X |
| authorships[10].author.display_name | Marina Nick |
| authorships[10].countries | GB |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[10].affiliations[0].raw_affiliation_string | University College London, London, United Kingdom |
| authorships[10].institutions[0].id | https://openalex.org/I45129253 |
| authorships[10].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[10].institutions[0].country_code | GB |
| authorships[10].institutions[0].display_name | University College London |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Marina Nick |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | University College London, London, United Kingdom |
| authorships[11].author.id | https://openalex.org/A5069612255 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Anwen E. Brown |
| authorships[11].countries | GB |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[11].affiliations[0].raw_affiliation_string | University College London, London, United Kingdom |
| authorships[11].institutions[0].id | https://openalex.org/I45129253 |
| authorships[11].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[11].institutions[0].country_code | GB |
| authorships[11].institutions[0].display_name | University College London |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Anwen E. Brown |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | University College London, London, United Kingdom |
| authorships[12].author.id | https://openalex.org/A5090625300 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Sirapat Tonitiwong |
| authorships[12].countries | GB |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[12].affiliations[0].raw_affiliation_string | University College London, London, United Kingdom |
| authorships[12].institutions[0].id | https://openalex.org/I45129253 |
| authorships[12].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[12].institutions[0].country_code | GB |
| authorships[12].institutions[0].display_name | University College London |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Sirapat Tonitiwong |
| authorships[12].is_corresponding | True |
| authorships[12].raw_affiliation_strings | University College London, London, United Kingdom |
| authorships[13].author.id | https://openalex.org/A5053484252 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-0705-5242 |
| authorships[13].author.display_name | David B. Sattelle |
| authorships[13].countries | GB |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[13].affiliations[0].raw_affiliation_string | University College London, London, United Kingdom |
| authorships[13].institutions[0].id | https://openalex.org/I45129253 |
| authorships[13].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[13].institutions[0].country_code | GB |
| authorships[13].institutions[0].display_name | University College London |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | David B. Sattelle |
| authorships[13].is_corresponding | True |
| authorships[13].raw_affiliation_strings | University College London, London, United Kingdom |
| authorships[14].author.id | https://openalex.org/A5026207705 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-9581-0377 |
| authorships[14].author.display_name | Matthew Berriman |
| authorships[14].countries | GB |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[14].affiliations[0].raw_affiliation_string | Wellcome Sanger Institute, Cambridge, United Kingdom |
| authorships[14].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[14].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[14].institutions[0].type | nonprofit |
| authorships[14].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[14].institutions[0].country_code | GB |
| authorships[14].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Matthew Berriman |
| authorships[14].is_corresponding | True |
| authorships[14].raw_affiliation_strings | Wellcome Sanger Institute, Cambridge, United Kingdom |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1371/journal.pntd.0011205 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A drug repurposing screen for whipworms informed by comparative genomics |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T10695 |
| primary_topic.field.id | https://openalex.org/fields/24 |
| primary_topic.field.display_name | Immunology and Microbiology |
| primary_topic.score | 0.9959999918937683 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2405 |
| primary_topic.subfield.display_name | Parasitology |
| primary_topic.display_name | Parasites and Host Interactions |
| related_works | https://openalex.org/W2899096130, https://openalex.org/W3190782215, https://openalex.org/W2902729297, https://openalex.org/W3110500039, https://openalex.org/W4255531208, https://openalex.org/W4396858017, https://openalex.org/W4400165188, https://openalex.org/W4206422705, https://openalex.org/W4320009247, https://openalex.org/W3186872001 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 4 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1371/journal.pntd.0011205 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S46544255 |
| best_oa_location.source.issn | 1935-2727, 1935-2735 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1935-2727 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | PLoS neglected tropical diseases |
| best_oa_location.source.host_organization | https://openalex.org/P4310315706 |
| best_oa_location.source.host_organization_name | Public Library of Science |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310315706 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | PLOS Neglected Tropical Diseases |
| best_oa_location.landing_page_url | https://doi.org/10.1371/journal.pntd.0011205 |
| primary_location.id | doi:10.1371/journal.pntd.0011205 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S46544255 |
| primary_location.source.issn | 1935-2727, 1935-2735 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1935-2727 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | PLoS neglected tropical diseases |
| primary_location.source.host_organization | https://openalex.org/P4310315706 |
| primary_location.source.host_organization_name | Public Library of Science |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315706 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | PLOS Neglected Tropical Diseases |
| primary_location.landing_page_url | https://doi.org/10.1371/journal.pntd.0011205 |
| publication_date | 2023-09-05 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W3092849554, https://openalex.org/W3028760640, https://openalex.org/W2165954373, https://openalex.org/W2759758131, https://openalex.org/W3033323532, https://openalex.org/W4287377885, https://openalex.org/W4285726060, https://openalex.org/W4220953001, https://openalex.org/W1739046993, https://openalex.org/W2894600215, https://openalex.org/W2780728213, https://openalex.org/W2900090807, https://openalex.org/W2755206132, https://openalex.org/W3164715889, https://openalex.org/W2001794172, https://openalex.org/W2134312868, https://openalex.org/W1975364461, https://openalex.org/W2586137411, https://openalex.org/W2767891136, https://openalex.org/W1935434993, https://openalex.org/W1971849220, https://openalex.org/W2212640525, https://openalex.org/W2461035437, https://openalex.org/W1581349283, https://openalex.org/W2821975400, https://openalex.org/W2118746801, https://openalex.org/W1772753157, https://openalex.org/W2137246574, https://openalex.org/W2970305725, https://openalex.org/W2050814521, https://openalex.org/W2292468523, https://openalex.org/W1992081956, https://openalex.org/W2614737934, https://openalex.org/W2782845571, https://openalex.org/W2055907171, https://openalex.org/W2204957929, https://openalex.org/W1993055068, https://openalex.org/W424584235, https://openalex.org/W2060647890, https://openalex.org/W2020024165, https://openalex.org/W2905144511, https://openalex.org/W1156765303, https://openalex.org/W6681094897, https://openalex.org/W2774455499, https://openalex.org/W2622236128, https://openalex.org/W4240398296, https://openalex.org/W2475466892, https://openalex.org/W2115726385, https://openalex.org/W2005908916, https://openalex.org/W1997680903, https://openalex.org/W2602215968, https://openalex.org/W1937048566, https://openalex.org/W1603551676, https://openalex.org/W2142040461 |
| referenced_works_count | 54 |
| abstract_inverted_index., | 83, 112 |
| abstract_inverted_index.. | 13, 108, 120, 142 |
| abstract_inverted_index.T | 107, 141 |
| abstract_inverted_index.a | 47 |
| abstract_inverted_index.14 | 96 |
| abstract_inverted_index.50 | 100, 104 |
| abstract_inverted_index.EC | 99 |
| abstract_inverted_index.In | 46, 160 |
| abstract_inverted_index.We | 29, 94 |
| abstract_inverted_index.an | 87 |
| abstract_inverted_index.as | 19, 23, 42 |
| abstract_inverted_index.at | 149 |
| abstract_inverted_index.be | 40, 155, 238 |
| abstract_inverted_index.by | 74, 157, 195, 216, 229, 235 |
| abstract_inverted_index.ex | 72, 110, 137 |
| abstract_inverted_index.in | 118, 128, 168, 207 |
| abstract_inverted_index.of | 1, 3, 77, 80, 102, 136, 165 |
| abstract_inverted_index.to | 63, 173, 203 |
| abstract_inverted_index.we | 52, 61, 69, 146 |
| abstract_inverted_index.(i) | 192 |
| abstract_inverted_index.409 | 54 |
| abstract_inverted_index.The | 133 |
| abstract_inverted_index.and | 113, 182, 188, 232 |
| abstract_inverted_index.are | 6, 16 |
| abstract_inverted_index.due | 172 |
| abstract_inverted_index.for | 35, 57, 90, 116, 240 |
| abstract_inverted_index.low | 27, 163 |
| abstract_inverted_index.may | 191, 237 |
| abstract_inverted_index.the | 9, 84, 122, 162, 196, 204, 208, 217, 230 |
| abstract_inverted_index.use | 59 |
| abstract_inverted_index.was | 130 |
| abstract_inverted_index.μM | 105 |
| abstract_inverted_index.≤ | 103 |
| abstract_inverted_index.(ii) | 212 |
| abstract_inverted_index.19%. | 132 |
| abstract_inverted_index.Here | 68 |
| abstract_inverted_index.This | 219 |
| abstract_inverted_index.best | 123 |
| abstract_inverted_index.drug | 214, 242 |
| abstract_inverted_index.have | 25, 30, 226 |
| abstract_inverted_index.high | 134 |
| abstract_inverted_index.hits | 139 |
| abstract_inverted_index.host | 197 |
| abstract_inverted_index.just | 131 |
| abstract_inverted_index.mice | 129, 169 |
| abstract_inverted_index.nine | 115 |
| abstract_inverted_index.seen | 127 |
| abstract_inverted_index.such | 22 |
| abstract_inverted_index.that | 60, 145, 153, 190, 221, 225 |
| abstract_inverted_index.vivo | 73, 111, 119, 138 |
| abstract_inverted_index.were | 147 |
| abstract_inverted_index.with | 8, 98 |
| abstract_inverted_index.worm | 66, 124 |
| abstract_inverted_index.(e.g. | 177, 184 |
| abstract_inverted_index.Novel | 14 |
| abstract_inverted_index.adult | 78 |
| abstract_inverted_index.could | 39, 154 |
| abstract_inverted_index.drugs | 33, 55 |
| abstract_inverted_index.host, | 231 |
| abstract_inverted_index.human | 37, 58, 91 |
| abstract_inverted_index.large | 209 |
| abstract_inverted_index.model | 89 |
| abstract_inverted_index.muris | 82, 109, 143 |
| abstract_inverted_index.novel | 43 |
| abstract_inverted_index.other | 36 |
| abstract_inverted_index.shows | 144 |
| abstract_inverted_index.their | 174 |
| abstract_inverted_index.these | 71, 166 |
| abstract_inverted_index.worms | 79, 205 |
| abstract_inverted_index.and/or | 211 |
| abstract_inverted_index.burden | 125 |
| abstract_inverted_index.drugs, | 21 |
| abstract_inverted_index.drugs. | 45, 159 |
| abstract_inverted_index.murine | 85 |
| abstract_inverted_index.needed | 18 |
| abstract_inverted_index.number | 135 |
| abstract_inverted_index.people | 4 |
| abstract_inverted_index.target | 64 |
| abstract_inverted_index.tested | 70 |
| abstract_inverted_index.tract, | 199 |
| abstract_inverted_index.uptake | 215, 234 |
| abstract_inverted_index.values | 101 |
| abstract_inverted_index.worms, | 236 |
| abstract_inverted_index.worms. | 218 |
| abstract_inverted_index.against | 106, 140, 244 |
| abstract_inverted_index.current | 20 |
| abstract_inverted_index.promote | 193 |
| abstract_inverted_index.reduced | 227 |
| abstract_inverted_index.suggest | 170 |
| abstract_inverted_index.testing | 117 |
| abstract_inverted_index.thereby | 200 |
| abstract_inverted_index.weight) | 181 |
| abstract_inverted_index.whether | 32 |
| abstract_inverted_index.However, | 121 |
| abstract_inverted_index.Hundreds | 0 |
| abstract_inverted_index.approved | 34, 56, 158 |
| abstract_inverted_index.chemical | 175 |
| abstract_inverted_index.diseases | 38 |
| abstract_inverted_index.efficacy | 164 |
| abstract_inverted_index.embedded | 206 |
| abstract_inverted_index.genomics | 50 |
| abstract_inverted_index.infected | 7 |
| abstract_inverted_index.millions | 2 |
| abstract_inverted_index.motility | 76 |
| abstract_inverted_index.parasite | 151 |
| abstract_inverted_index.previous | 48 |
| abstract_inverted_index.proteins | 152 |
| abstract_inverted_index.reducing | 201 |
| abstract_inverted_index.restrict | 213 |
| abstract_inverted_index.selected | 114 |
| abstract_inverted_index.targeted | 156 |
| abstract_inverted_index.urgently | 17 |
| abstract_inverted_index.whipworm | 10, 92 |
| abstract_inverted_index.Trichuris | 11, 81 |
| abstract_inverted_index.analogues | 224 |
| abstract_inverted_index.analysis, | 51 |
| abstract_inverted_index.assessing | 75 |
| abstract_inverted_index.compounds | 97, 167 |
| abstract_inverted_index.contrast, | 161 |
| abstract_inverted_index.efficacy. | 28 |
| abstract_inverted_index.increased | 233 |
| abstract_inverted_index.indicates | 220 |
| abstract_inverted_index.molecular | 180 |
| abstract_inverted_index.necessary | 239 |
| abstract_inverted_index.parasitic | 65 |
| abstract_inverted_index.polarity, | 179 |
| abstract_inverted_index.predicted | 62 |
| abstract_inverted_index.proteins. | 67 |
| abstract_inverted_index.reduction | 126 |
| abstract_inverted_index.research. | 93 |
| abstract_inverted_index.trichiura | 12 |
| abstract_inverted_index.whipworm, | 86 |
| abstract_inverted_index.worldwide | 5 |
| abstract_inverted_index.absorption | 194, 228 |
| abstract_inverted_index.challenges | 171 |
| abstract_inverted_index.excretion) | 189 |
| abstract_inverted_index.identified | 53, 95 |
| abstract_inverted_index.intestine, | 210 |
| abstract_inverted_index.predicting | 150 |
| abstract_inverted_index.properties | 176 |
| abstract_inverted_index.relatively | 26 |
| abstract_inverted_index.repurposed | 41 |
| abstract_inverted_index.structural | 223 |
| abstract_inverted_index.successful | 148, 241 |
| abstract_inverted_index.treatments | 15 |
| abstract_inverted_index.whipworms. | 245 |
| abstract_inverted_index.absorption, | 185 |
| abstract_inverted_index.comparative | 49 |
| abstract_inverted_index.development | 243 |
| abstract_inverted_index.established | 88 |
| abstract_inverted_index.identifying | 222 |
| abstract_inverted_index.metabolism, | 187 |
| abstract_inverted_index.albendazole, | 24 |
| abstract_inverted_index.availability | 202 |
| abstract_inverted_index.investigated | 31 |
| abstract_inverted_index.anti-whipworm | 44 |
| abstract_inverted_index.distribution, | 186 |
| abstract_inverted_index.lipophilicity, | 178 |
| abstract_inverted_index.gastrointestinal | 198 |
| abstract_inverted_index.pharmacokinetics | 183 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5069612255, https://openalex.org/A5040476896, https://openalex.org/A5101722036, https://openalex.org/A5056001112, https://openalex.org/A5082664707, https://openalex.org/A5090625300, https://openalex.org/A5017711874, https://openalex.org/A5011572601, https://openalex.org/A5032015519, https://openalex.org/A5072410641, https://openalex.org/A5112994725, https://openalex.org/A5028251855, https://openalex.org/A5105938350, https://openalex.org/A5053484252, https://openalex.org/A5026207705 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I2802476451, https://openalex.org/I45129253 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7099999785423279 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.83739548 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |