A first report of progressive multifocal leukoencephalopathy in childhood-onset NMOSD Article Swipe
Pakeeran Siriratnam
,
Simon Gosling
,
Maneesh Bhojak
,
Michael J. Griffiths
,
Rachel Kneen
,
Evangeline Wassmer
,
Saif Huda
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1177/13524585251331855
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1177/13524585251331855
Background: Progressive multifocal leukoencephalopathy (PML) has not been reported in pediatric neuromyelitis optica spectrum disorder (NMOSD) and rarely described in children. Objectives: To report a case of PML in childhood-onset NMOSD. Methods: A single retrospective case report. Results: Nine years after diagnosis of aquaporin-4 antibody positive NMOSD, a 17-year-old boy treated with rituximab presented with painless right visual loss over 6 weeks coinciding with CD19 repopulation. Acute relapse treatment was given but he continued to deteriorate, and JC virus was detected in cerebrospinal fluid confirming PML. Conclusion: PML can occur in childhood-onset NMOSD and protracted clinical presentations with unusual radiological features should prompt JCV testing. Balancing effective immunosuppression while mitigating the risks of associated complications in long-term relapsing conditions remains a challenge.
Related Topics
Concepts
Progressive multifocal leukoencephalopathy
Medicine
Neuromyelitis optica
Rituximab
Pediatrics
Multiple sclerosis
Immunosuppression
Natalizumab
Leukoencephalopathy
Spectrum disorder
Demyelinating Disorder
Myelin oligodendrocyte glycoprotein
Acute disseminated encephalomyelitis
Magnetic resonance imaging
Immunology
Radiology
Antibody
Experimental autoimmune encephalomyelitis
Psychiatry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/13524585251331855
- OA Status
- hybrid
- Cited By
- 1
- References
- 10
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409591686
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409591686Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/13524585251331855Digital Object Identifier
- Title
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A first report of progressive multifocal leukoencephalopathy in childhood-onset NMOSDWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-18Full publication date if available
- Authors
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Pakeeran Siriratnam, Simon Gosling, Maneesh Bhojak, Michael J. Griffiths, Rachel Kneen, Evangeline Wassmer, Saif HudaList of authors in order
- Landing page
-
https://doi.org/10.1177/13524585251331855Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1177/13524585251331855Direct OA link when available
- Concepts
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Progressive multifocal leukoencephalopathy, Medicine, Neuromyelitis optica, Rituximab, Pediatrics, Multiple sclerosis, Immunosuppression, Natalizumab, Leukoencephalopathy, Spectrum disorder, Demyelinating Disorder, Myelin oligodendrocyte glycoprotein, Acute disseminated encephalomyelitis, Magnetic resonance imaging, Immunology, Radiology, Antibody, Experimental autoimmune encephalomyelitis, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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10Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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