A Fragment‐Based Approach to Understanding Inhibition of 1‐Deoxy‐D ‐Xylulose‐5‐Phosphate Reductoisomerase
Article Swipe
Ludovic Mercklé
,
Ana de Andrés‐Gómez
,
Bethany Dick
,
Russell J. Cox
,
Christopher R. A. Godfrey
·
YOU?
·
· 2005
· Open Access
·
· DOI: https://doi.org/10.1002/cbic.200500061
YOU?
·
· 2005
· Open Access
·
· DOI: https://doi.org/10.1002/cbic.200500061
The inhibition of 1‐deoxy‐ D ‐xylulose‐5‐phosphate reductoisomerase (DXR) by fosmidomycin was studied by using a kinetic assay based on the consumption of NADPH and synthetic substrate. Fosmidomycin is a slow tight‐binding inhibitor of DXR that shows strong negative cooperativity (| h |=0.3) in binding. Cooperativity is displayed during the initial (weak, K 0.5 =10 μ M ) binding event and does not change as the binding tightens to the equilibrium value of 0.9 n M over a period of seconds to minutes. A series of fosmidomycin fragments was examined, but all showed much weaker inhibition, in the m M range. A series of cyclic fosmidomycin analogues was also synthesised and tested, but these showed high‐μ M binding at best. None of the synthetic compounds showed time‐dependent inhibition. We concluded that the slow tight‐binding behaviour, and perhaps also cooperativity, are mediated by significant reorganisation of the active site upon fosmidomycin binding. This makes the rational design of new inhibitors of DXR difficult at best.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cbic.200500061
- OA Status
- green
- Cited By
- 35
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2159551001
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2159551001Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/cbic.200500061Digital Object Identifier
- Title
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A Fragment‐Based Approach to Understanding Inhibition of 1‐Deoxy‐
D ‐Xylulose‐5‐Phosphate ReductoisomeraseWork title - Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2005Year of publication
- Publication date
-
2005-08-23Full publication date if available
- Authors
-
Ludovic Mercklé, Ana de Andrés‐Gómez, Bethany Dick, Russell J. Cox, Christopher R. A. GodfreyList of authors in order
- Landing page
-
https://doi.org/10.1002/cbic.200500061Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://doi.org/10.7270/q26d5rhbDirect OA link when available
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Cooperativity, Cooperative binding, Chemistry, Phosphate buffered saline, Stereochemistry, Binding site, Substrate (aquarium), Enzyme, Biochemistry, Biology, Chromatography, EcologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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35Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2022: 2, 2020: 2, 2019: 2Per-year citation counts (last 5 years)
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25Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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