A functional spiking-neuron model of activity-silent working memory in humans based on calcium-mediated short-term synaptic plasticity Article Swipe
Matthijs Pals
,
Terrence C. Stewart
,
Elkan G. Akyürek
,
Jelmer P. Borst
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pcbi.1007936
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pcbi.1007936
In this paper, we present a functional spiking-neuron model of human working memory (WM). This model combines neural firing for encoding of information with activity-silent maintenance. While it used to be widely assumed that information in WM is maintained through persistent recurrent activity, recent studies have shown that information can be maintained without persistent firing; instead, information can be stored in activity-silent states. A candidate mechanism underlying this type of storage is short-term synaptic plasticity (STSP), by which the strength of connections between neurons rapidly changes to encode new information. To demonstrate that STSP can lead to functional behavior, we integrated STSP by means of calcium-mediated synaptic facilitation in a large-scale spiking-neuron model and added a decision mechanism. The model was used to simulate a recent study that measured behavior and EEG activity of participants in three delayed-response tasks. In these tasks, one or two visual gratings had to be maintained in WM, and compared to subsequent probes. The original study demonstrated that WM contents and its priority status could be decoded from neural activity elicited by a task-irrelevant stimulus displayed during the activity-silent maintenance period. In support of our model, we show that it can perform these tasks, and that both its behavior as well as its neural representations are in agreement with the human data. We conclude that information in WM can be effectively maintained in activity-silent states by means of calcium-mediated STSP.
Related Topics
Concepts
Neuroscience
Synaptic plasticity
Facilitation
Calcium imaging
Stimulus (psychology)
Neural facilitation
Computer science
ENCODE
Working memory
Neuron
Mechanism (biology)
Neuroplasticity
Premovement neuronal activity
Psychology
Calcium
Biology
Cognitive psychology
Excitatory postsynaptic potential
Cognition
Chemistry
Inhibitory postsynaptic potential
Physics
Biochemistry
Receptor
Gene
Quantum mechanics
Organic chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pcbi.1007936
- https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007936&type=printable
- OA Status
- gold
- Cited By
- 29
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3032992368
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3032992368Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pcbi.1007936Digital Object Identifier
- Title
-
A functional spiking-neuron model of activity-silent working memory in humans based on calcium-mediated short-term synaptic plasticityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-06-09Full publication date if available
- Authors
-
Matthijs Pals, Terrence C. Stewart, Elkan G. Akyürek, Jelmer P. BorstList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pcbi.1007936Publisher landing page
- PDF URL
-
https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007936&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007936&type=printableDirect OA link when available
- Concepts
-
Neuroscience, Synaptic plasticity, Facilitation, Calcium imaging, Stimulus (psychology), Neural facilitation, Computer science, ENCODE, Working memory, Neuron, Mechanism (biology), Neuroplasticity, Premovement neuronal activity, Psychology, Calcium, Biology, Cognitive psychology, Excitatory postsynaptic potential, Cognition, Chemistry, Inhibitory postsynaptic potential, Physics, Biochemistry, Receptor, Gene, Quantum mechanics, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
29Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 9, 2023: 3, 2022: 5, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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