A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair Article Swipe
Simeon C. Daeschler
,
Katelyn J.W. So
,
Konstantin Feinberg
,
Marina Manoraj
,
Jenny Cheung
,
Jennifer Zhang
,
Kaveh Mirmoeini
,
J. Paul Santerre
,
Tessa Gordon
,
Gregory H. Borschel
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4103/nrr.nrr-d-22-01198
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4103/nrr.nrr-d-22-01198
JOURNAL/nrgr/04.03/01300535-202501000-00036/figure1/v/2025-06-04T152002Z/r/image-tiff Axonal regeneration following surgical nerve repair is slow and often incomplete, resulting in poor functional recovery which sometimes contributes to lifelong disability. Currently, there are no FDA-approved therapies available to promote nerve regeneration. Tacrolimus accelerates axonal regeneration, but systemic side effects presently outweigh its potential benefits for peripheral nerve surgery. The authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site, with suitable properties for scalable production and clinical application, aiming to promote nerve regeneration and functional recovery with minimal systemic drug exposure. Tacrolimus is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 days. Size and drug loading are adjustable for applications in small and large caliber nerves, and the wrap degrades within 120 days into biocompatible byproducts. Tacrolimus released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80% compared with systemic delivery. Given its surgical suitability and preclinical efficacy and safety, this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/nrr.nrr-d-22-01198
- OA Status
- gold
- Cited By
- 8
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391436024
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391436024Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4103/nrr.nrr-d-22-01198Digital Object Identifier
- Title
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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repairWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-31Full publication date if available
- Authors
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Simeon C. Daeschler, Katelyn J.W. So, Konstantin Feinberg, Marina Manoraj, Jenny Cheung, Jennifer Zhang, Kaveh Mirmoeini, J. Paul Santerre, Tessa Gordon, Gregory H. BorschelList of authors in order
- Landing page
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https://doi.org/10.4103/nrr.nrr-d-22-01198Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.4103/nrr.nrr-d-22-01198Direct OA link when available
- Concepts
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Regeneration (biology), Medicine, Tacrolimus, Axon, Sciatic nerve, Nerve guidance conduit, Surgery, Anesthesia, Transplantation, Anatomy, Biology, Cell biologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 4, 2023: 1Per-year citation counts (last 5 years)
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66Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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