A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator Article Swipe
Emiliano Manzo
,
Aniello Schiano Moriello
,
Francesco Tinto
,
Roberta Verde
,
Marco Allarà
,
Luciano De Petrocellis
,
Ester Pagano
,
Angelo A. Izzo
,
Vincenzo Di Marzo
,
Stefania Petrosino
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/cells10020450
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/cells10020450
Palmitoylethanolamide (PEA) is an endogenous anti-inflammatory lipid mediator and a widely used nutraceutical. In this study, we designed, realized, and tested a drug-carrier conjugate between PEA (the active drug) and glucuronic acid (the carrier). The conjugate, named GLUPEA, was characterized for its capability of increasing PEA levels and exerting anti-inflammatory activity both in vitro and in vivo. GLUPEA treatment, compared to the same concentration of PEA, resulted in higher cellular amounts of PEA and the endocannabinoid 2-arachidonoyl glycerol (2-AG), and increased 2-AG-induced transient receptor potential vanilloid type 1 (TRPV1) channel desensitization to capsaicin. GLUPEA inhibited pro-inflammatory monocyte chemoattractant protein 2 (MCP-2) release from stimulated keratinocytes, and it was almost as efficacious as ultra-micronized PEA at reducing colitis in dinitrobenzene sulfonic acid (DNBS)-injected mice when using the same dose. GLUPEA is a novel pro-drug able to efficiently mimic the anti-inflammatory and endocannabinoid enhancing actions of PEA.
Related Topics
Concepts
Palmitoylethanolamide
Chemistry
Pharmacology
Glucuronic acid
TRPV1
Conjugate
Endocannabinoid system
Biochemistry
Drug delivery
Capsaicin
In vivo
Cannabinoid
Cannabinoid receptor
Receptor
Transient receptor potential channel
Biology
Polysaccharide
Agonist
Organic chemistry
Mathematics
Biotechnology
Mathematical analysis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells10020450
- https://www.mdpi.com/2073-4409/10/2/450/pdf?version=1614242368
- OA Status
- gold
- Cited By
- 6
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3132922739
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3132922739Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cells10020450Digital Object Identifier
- Title
-
A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential BioregulatorWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-02-20Full publication date if available
- Authors
-
Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A. Izzo, Vincenzo Di Marzo, Stefania PetrosinoList of authors in order
- Landing page
-
https://doi.org/10.3390/cells10020450Publisher landing page
- PDF URL
-
https://www.mdpi.com/2073-4409/10/2/450/pdf?version=1614242368Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2073-4409/10/2/450/pdf?version=1614242368Direct OA link when available
- Concepts
-
Palmitoylethanolamide, Chemistry, Pharmacology, Glucuronic acid, TRPV1, Conjugate, Endocannabinoid system, Biochemistry, Drug delivery, Capsaicin, In vivo, Cannabinoid, Cannabinoid receptor, Receptor, Transient receptor potential channel, Biology, Polysaccharide, Agonist, Organic chemistry, Mathematics, Biotechnology, Mathematical analysisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 2, 2022: 2Per-year citation counts (last 5 years)
- References (count)
-
61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3132922739 |
|---|---|
| doi | https://doi.org/10.3390/cells10020450 |
| ids.doi | https://doi.org/10.3390/cells10020450 |
| ids.mag | 3132922739 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33672574 |
| ids.openalex | https://openalex.org/W3132922739 |
| fwci | 0.69133945 |
| mesh[0].qualifier_ui | Q000737 |
| mesh[0].descriptor_ui | D000577 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | chemistry |
| mesh[0].descriptor_name | Amides |
| mesh[1].qualifier_ui | Q000494 |
| mesh[1].descriptor_ui | D000577 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | pharmacology |
| mesh[1].descriptor_name | Amides |
| mesh[2].qualifier_ui | Q000627 |
| mesh[2].descriptor_ui | D000577 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | therapeutic use |
| mesh[2].descriptor_name | Amides |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000818 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Animals |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D001095 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Arachidonic Acids |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D002118 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Calcium |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D054412 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Chemokine CCL8 |
| mesh[7].qualifier_ui | Q000139 |
| mesh[7].descriptor_ui | D003092 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | chemically induced |
| mesh[7].descriptor_name | Colitis |
| mesh[8].qualifier_ui | Q000188 |
| mesh[8].descriptor_ui | D003092 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | drug therapy |
| mesh[8].descriptor_name | Colitis |
| mesh[9].qualifier_ui | Q000187 |
| mesh[9].descriptor_ui | D003106 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | drug effects |
| mesh[9].descriptor_name | Colon |
| mesh[10].qualifier_ui | Q000473 |
| mesh[10].descriptor_ui | D003106 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | pathology |
| mesh[10].descriptor_name | Colon |
| mesh[11].qualifier_ui | Q000031 |
| mesh[11].descriptor_ui | D004139 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | analogs & derivatives |
| mesh[11].descriptor_name | Dinitrofluorobenzene |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D016503 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Drug Delivery Systems |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D063388 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Endocannabinoids |
| mesh[14].qualifier_ui | Q000737 |
| mesh[14].descriptor_ui | D004983 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | chemistry |
| mesh[14].descriptor_name | Ethanolamines |
| mesh[15].qualifier_ui | Q000494 |
| mesh[15].descriptor_ui | D004983 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pharmacology |
| mesh[15].descriptor_name | Ethanolamines |
| mesh[16].qualifier_ui | Q000627 |
| mesh[16].descriptor_ui | D004983 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | therapeutic use |
| mesh[16].descriptor_name | Ethanolamines |
| mesh[17].qualifier_ui | Q000737 |
| mesh[17].descriptor_ui | D020723 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | chemistry |
| mesh[17].descriptor_name | Glucuronic Acid |
| mesh[18].qualifier_ui | Q000494 |
| mesh[18].descriptor_ui | D020723 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | pharmacology |
| mesh[18].descriptor_name | Glucuronic Acid |
| mesh[19].qualifier_ui | Q000627 |
| mesh[19].descriptor_ui | D020723 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | therapeutic use |
| mesh[19].descriptor_name | Glucuronic Acid |
| mesh[20].qualifier_ui | Q000378 |
| mesh[20].descriptor_ui | D005989 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | metabolism |
| mesh[20].descriptor_name | Glycerides |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D057809 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | HEK293 Cells |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D000084282 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | HaCaT Cells |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D006801 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Humans |
| mesh[24].qualifier_ui | Q000187 |
| mesh[24].descriptor_ui | D015640 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | drug effects |
| mesh[24].descriptor_name | Ion Channel Gating |
| mesh[25].qualifier_ui | Q000187 |
| mesh[25].descriptor_ui | D015603 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | drug effects |
| mesh[25].descriptor_name | Keratinocytes |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D015603 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Keratinocytes |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D008297 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Male |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D008813 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Mice, Inbred ICR |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D008954 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Models, Biological |
| mesh[30].qualifier_ui | Q000737 |
| mesh[30].descriptor_ui | D010169 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | chemistry |
| mesh[30].descriptor_name | Palmitic Acids |
| mesh[31].qualifier_ui | Q000494 |
| mesh[31].descriptor_ui | D010169 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | pharmacology |
| mesh[31].descriptor_name | Palmitic Acids |
| mesh[32].qualifier_ui | Q000627 |
| mesh[32].descriptor_ui | D010169 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | therapeutic use |
| mesh[32].descriptor_name | Palmitic Acids |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D009195 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Peroxidase |
| mesh[34].qualifier_ui | Q000494 |
| mesh[34].descriptor_ui | D011070 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | pharmacology |
| mesh[34].descriptor_name | Poly I-C |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D050916 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | TRPV Cation Channels |
| mesh[36].qualifier_ui | Q000737 |
| mesh[36].descriptor_ui | D000577 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | chemistry |
| mesh[36].descriptor_name | Amides |
| mesh[37].qualifier_ui | Q000494 |
| mesh[37].descriptor_ui | D000577 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | pharmacology |
| mesh[37].descriptor_name | Amides |
| mesh[38].qualifier_ui | Q000627 |
| mesh[38].descriptor_ui | D000577 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | therapeutic use |
| mesh[38].descriptor_name | Amides |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D000818 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Animals |
| mesh[40].qualifier_ui | Q000378 |
| mesh[40].descriptor_ui | D001095 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | metabolism |
| mesh[40].descriptor_name | Arachidonic Acids |
| mesh[41].qualifier_ui | Q000378 |
| mesh[41].descriptor_ui | D002118 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | metabolism |
| mesh[41].descriptor_name | Calcium |
| mesh[42].qualifier_ui | Q000378 |
| mesh[42].descriptor_ui | D054412 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | metabolism |
| mesh[42].descriptor_name | Chemokine CCL8 |
| mesh[43].qualifier_ui | Q000139 |
| mesh[43].descriptor_ui | D003092 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | chemically induced |
| mesh[43].descriptor_name | Colitis |
| mesh[44].qualifier_ui | Q000188 |
| mesh[44].descriptor_ui | D003092 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | drug therapy |
| mesh[44].descriptor_name | Colitis |
| mesh[45].qualifier_ui | Q000187 |
| mesh[45].descriptor_ui | D003106 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | drug effects |
| mesh[45].descriptor_name | Colon |
| mesh[46].qualifier_ui | Q000473 |
| mesh[46].descriptor_ui | D003106 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | pathology |
| mesh[46].descriptor_name | Colon |
| mesh[47].qualifier_ui | Q000031 |
| mesh[47].descriptor_ui | D004139 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | analogs & derivatives |
| mesh[47].descriptor_name | Dinitrofluorobenzene |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D016503 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Drug Delivery Systems |
| mesh[49].qualifier_ui | Q000378 |
| mesh[49].descriptor_ui | D063388 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | metabolism |
| mesh[49].descriptor_name | Endocannabinoids |
| type | article |
| title | A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator |
| biblio.issue | 2 |
| biblio.volume | 10 |
| biblio.last_page | 450 |
| biblio.first_page | 450 |
| topics[0].id | https://openalex.org/T10414 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2736 |
| topics[0].subfield.display_name | Pharmacology |
| topics[0].display_name | Cannabis and Cannabinoid Research |
| topics[1].id | https://openalex.org/T10985 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9455000162124634 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2805 |
| topics[1].subfield.display_name | Cognitive Neuroscience |
| topics[1].display_name | Sleep and Wakefulness Research |
| is_xpac | False |
| apc_list.value | 2200 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2382 |
| apc_paid.value | 2200 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2382 |
| concepts[0].id | https://openalex.org/C2777767828 |
| concepts[0].level | 5 |
| concepts[0].score | 0.9677699208259583 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2159860 |
| concepts[0].display_name | Palmitoylethanolamide |
| concepts[1].id | https://openalex.org/C185592680 |
| concepts[1].level | 0 |
| concepts[1].score | 0.6893538236618042 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[1].display_name | Chemistry |
| concepts[2].id | https://openalex.org/C98274493 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6750125288963318 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[2].display_name | Pharmacology |
| concepts[3].id | https://openalex.org/C2776648616 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6651031970977783 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q409216 |
| concepts[3].display_name | Glucuronic acid |
| concepts[4].id | https://openalex.org/C160145004 |
| concepts[4].level | 4 |
| concepts[4].score | 0.6422843933105469 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q413209 |
| concepts[4].display_name | TRPV1 |
| concepts[5].id | https://openalex.org/C197336794 |
| concepts[5].level | 2 |
| concepts[5].score | 0.6201760172843933 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q5161150 |
| concepts[5].display_name | Conjugate |
| concepts[6].id | https://openalex.org/C46721173 |
| concepts[6].level | 3 |
| concepts[6].score | 0.5906715393066406 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q368952 |
| concepts[6].display_name | Endocannabinoid system |
| concepts[7].id | https://openalex.org/C55493867 |
| concepts[7].level | 1 |
| concepts[7].score | 0.4944124221801758 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[7].display_name | Biochemistry |
| concepts[8].id | https://openalex.org/C2779820397 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4404894709587097 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1392806 |
| concepts[8].display_name | Drug delivery |
| concepts[9].id | https://openalex.org/C2780051329 |
| concepts[9].level | 3 |
| concepts[9].score | 0.43280211091041565 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q273169 |
| concepts[9].display_name | Capsaicin |
| concepts[10].id | https://openalex.org/C207001950 |
| concepts[10].level | 2 |
| concepts[10].score | 0.41697192192077637 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q141124 |
| concepts[10].display_name | In vivo |
| concepts[11].id | https://openalex.org/C2780871563 |
| concepts[11].level | 3 |
| concepts[11].score | 0.41190996766090393 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q422936 |
| concepts[11].display_name | Cannabinoid |
| concepts[12].id | https://openalex.org/C148001335 |
| concepts[12].level | 4 |
| concepts[12].score | 0.27694427967071533 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q421237 |
| concepts[12].display_name | Cannabinoid receptor |
| concepts[13].id | https://openalex.org/C170493617 |
| concepts[13].level | 2 |
| concepts[13].score | 0.25359106063842773 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[13].display_name | Receptor |
| concepts[14].id | https://openalex.org/C155164980 |
| concepts[14].level | 3 |
| concepts[14].score | 0.17272153496742249 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q304043 |
| concepts[14].display_name | Transient receptor potential channel |
| concepts[15].id | https://openalex.org/C86803240 |
| concepts[15].level | 0 |
| concepts[15].score | 0.16850778460502625 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[15].display_name | Biology |
| concepts[16].id | https://openalex.org/C100817775 |
| concepts[16].level | 2 |
| concepts[16].score | 0.14814838767051697 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q134219 |
| concepts[16].display_name | Polysaccharide |
| concepts[17].id | https://openalex.org/C2778938600 |
| concepts[17].level | 3 |
| concepts[17].score | 0.09890109300613403 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q389934 |
| concepts[17].display_name | Agonist |
| concepts[18].id | https://openalex.org/C178790620 |
| concepts[18].level | 1 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[18].display_name | Organic chemistry |
| concepts[19].id | https://openalex.org/C33923547 |
| concepts[19].level | 0 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q395 |
| concepts[19].display_name | Mathematics |
| concepts[20].id | https://openalex.org/C150903083 |
| concepts[20].level | 1 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q7108 |
| concepts[20].display_name | Biotechnology |
| concepts[21].id | https://openalex.org/C134306372 |
| concepts[21].level | 1 |
| concepts[21].score | 0.0 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q7754 |
| concepts[21].display_name | Mathematical analysis |
| keywords[0].id | https://openalex.org/keywords/palmitoylethanolamide |
| keywords[0].score | 0.9677699208259583 |
| keywords[0].display_name | Palmitoylethanolamide |
| keywords[1].id | https://openalex.org/keywords/chemistry |
| keywords[1].score | 0.6893538236618042 |
| keywords[1].display_name | Chemistry |
| keywords[2].id | https://openalex.org/keywords/pharmacology |
| keywords[2].score | 0.6750125288963318 |
| keywords[2].display_name | Pharmacology |
| keywords[3].id | https://openalex.org/keywords/glucuronic-acid |
| keywords[3].score | 0.6651031970977783 |
| keywords[3].display_name | Glucuronic acid |
| keywords[4].id | https://openalex.org/keywords/trpv1 |
| keywords[4].score | 0.6422843933105469 |
| keywords[4].display_name | TRPV1 |
| keywords[5].id | https://openalex.org/keywords/conjugate |
| keywords[5].score | 0.6201760172843933 |
| keywords[5].display_name | Conjugate |
| keywords[6].id | https://openalex.org/keywords/endocannabinoid-system |
| keywords[6].score | 0.5906715393066406 |
| keywords[6].display_name | Endocannabinoid system |
| keywords[7].id | https://openalex.org/keywords/biochemistry |
| keywords[7].score | 0.4944124221801758 |
| keywords[7].display_name | Biochemistry |
| keywords[8].id | https://openalex.org/keywords/drug-delivery |
| keywords[8].score | 0.4404894709587097 |
| keywords[8].display_name | Drug delivery |
| keywords[9].id | https://openalex.org/keywords/capsaicin |
| keywords[9].score | 0.43280211091041565 |
| keywords[9].display_name | Capsaicin |
| keywords[10].id | https://openalex.org/keywords/in-vivo |
| keywords[10].score | 0.41697192192077637 |
| keywords[10].display_name | In vivo |
| keywords[11].id | https://openalex.org/keywords/cannabinoid |
| keywords[11].score | 0.41190996766090393 |
| keywords[11].display_name | Cannabinoid |
| keywords[12].id | https://openalex.org/keywords/cannabinoid-receptor |
| keywords[12].score | 0.27694427967071533 |
| keywords[12].display_name | Cannabinoid receptor |
| keywords[13].id | https://openalex.org/keywords/receptor |
| keywords[13].score | 0.25359106063842773 |
| keywords[13].display_name | Receptor |
| keywords[14].id | https://openalex.org/keywords/transient-receptor-potential-channel |
| keywords[14].score | 0.17272153496742249 |
| keywords[14].display_name | Transient receptor potential channel |
| keywords[15].id | https://openalex.org/keywords/biology |
| keywords[15].score | 0.16850778460502625 |
| keywords[15].display_name | Biology |
| keywords[16].id | https://openalex.org/keywords/polysaccharide |
| keywords[16].score | 0.14814838767051697 |
| keywords[16].display_name | Polysaccharide |
| keywords[17].id | https://openalex.org/keywords/agonist |
| keywords[17].score | 0.09890109300613403 |
| keywords[17].display_name | Agonist |
| language | en |
| locations[0].id | doi:10.3390/cells10020450 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2736626452 |
| locations[0].source.issn | 2073-4409 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2073-4409 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Cells |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2073-4409/10/2/450/pdf?version=1614242368 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cells |
| locations[0].landing_page_url | https://doi.org/10.3390/cells10020450 |
| locations[1].id | pmid:33672574 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cells |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33672574 |
| locations[2].id | pmh:oai:doaj.org/article:fe521107ee0b450eb5f8063acaaf0966 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Cells, Vol 10, Iss 2, p 450 (2021) |
| locations[2].landing_page_url | https://doaj.org/article/fe521107ee0b450eb5f8063acaaf0966 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:7924038 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Cells |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7924038 |
| locations[4].id | pmh:oai:mdpi.com:/2073-4409/10/2/450/ |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306400947 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | True |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | MDPI (MDPI AG) |
| locations[4].source.host_organization | https://openalex.org/I4210097602 |
| locations[4].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[4].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[4].license | cc-by |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/cc-by |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Cells; Volume 10; Issue 2; Pages: 450 |
| locations[4].landing_page_url | https://dx.doi.org/10.3390/cells10020450 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5027900181 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-7394-020X |
| authorships[0].author.display_name | Emiliano Manzo |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210147106 |
| authorships[0].affiliations[0].raw_affiliation_string | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I4210147106 |
| authorships[0].institutions[0].ror | https://ror.org/03wyf0g15 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210147106 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | Istituto di Chimica Biomolecolare |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Emiliano Manzo |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[1].author.id | https://openalex.org/A5011475191 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-4165-6711 |
| authorships[1].author.display_name | Aniello Schiano Moriello |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210147106 |
| authorships[1].affiliations[0].raw_affiliation_string | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[1].affiliations[1].raw_affiliation_string | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[1].affiliations[2].raw_affiliation_string | Epitech Group S.p.A., 35030 Saccolongo, Padova, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I4210147106 |
| authorships[1].institutions[0].ror | https://ror.org/03wyf0g15 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210147106 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | Istituto di Chimica Biomolecolare |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Aniello Schiano Moriello |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy, Epitech Group S.p.A., 35030 Saccolongo, Padova, Italy, Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[2].author.id | https://openalex.org/A5068188174 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-7818-591X |
| authorships[2].author.display_name | Francesco Tinto |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210147106 |
| authorships[2].affiliations[0].raw_affiliation_string | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I4210147106 |
| authorships[2].institutions[0].ror | https://ror.org/03wyf0g15 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210147106 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | Istituto di Chimica Biomolecolare |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Francesco Tinto |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[3].author.id | https://openalex.org/A5046726227 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-8103-6616 |
| authorships[3].author.display_name | Roberta Verde |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210147106 |
| authorships[3].affiliations[0].raw_affiliation_string | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[3].affiliations[1].raw_affiliation_string | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I4210147106 |
| authorships[3].institutions[0].ror | https://ror.org/03wyf0g15 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210147106 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | Istituto di Chimica Biomolecolare |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Roberta Verde |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy, Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[4].author.id | https://openalex.org/A5033073024 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-4305-5760 |
| authorships[4].author.display_name | Marco Allarà |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210147106 |
| authorships[4].affiliations[0].raw_affiliation_string | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[4].affiliations[1].raw_affiliation_string | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[4].affiliations[2].raw_affiliation_string | Epitech Group S.p.A., 35030 Saccolongo, Padova, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I4210147106 |
| authorships[4].institutions[0].ror | https://ror.org/03wyf0g15 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210147106 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | Istituto di Chimica Biomolecolare |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Marco Allarà |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy, Epitech Group S.p.A., 35030 Saccolongo, Padova, Italy, Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[5].author.id | https://openalex.org/A5076395210 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6131-0470 |
| authorships[5].author.display_name | Luciano De Petrocellis |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].raw_affiliation_string | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I4210147106 |
| authorships[5].affiliations[1].raw_affiliation_string | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[5].institutions[0].id | https://openalex.org/I4210147106 |
| authorships[5].institutions[0].ror | https://ror.org/03wyf0g15 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210147106 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | Istituto di Chimica Biomolecolare |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Luciano De Petrocellis |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy, Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[6].author.id | https://openalex.org/A5050729130 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-2872-1734 |
| authorships[6].author.display_name | Ester Pagano |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[6].affiliations[0].raw_affiliation_string | Dipartimento di Farmacia, Università di Napoli Federico II, 80138 Naples, Napoli, Italy |
| authorships[6].affiliations[1].raw_affiliation_string | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[6].institutions[0].id | https://openalex.org/I71267560 |
| authorships[6].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | University of Naples Federico II |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ester Pagano |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Dipartimento di Farmacia, Università di Napoli Federico II, 80138 Naples, Napoli, Italy, Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[7].author.id | https://openalex.org/A5086116359 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8557-2133 |
| authorships[7].author.display_name | Angelo A. Izzo |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[7].affiliations[0].raw_affiliation_string | Dipartimento di Farmacia, Università di Napoli Federico II, 80138 Naples, Napoli, Italy |
| authorships[7].affiliations[1].raw_affiliation_string | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[7].institutions[0].id | https://openalex.org/I71267560 |
| authorships[7].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | University of Naples Federico II |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Angelo A. Izzo |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Dipartimento di Farmacia, Università di Napoli Federico II, 80138 Naples, Napoli, Italy, Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[8].author.id | https://openalex.org/A5007484138 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-1490-3070 |
| authorships[8].author.display_name | Vincenzo Di Marzo |
| authorships[8].countries | CA, IT |
| authorships[8].affiliations[0].raw_affiliation_string | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I4210147106 |
| authorships[8].affiliations[1].raw_affiliation_string | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[8].affiliations[2].institution_ids | https://openalex.org/I43406934 |
| authorships[8].affiliations[2].raw_affiliation_string | Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, CRIUCPQ and INAF-Centre NUTRISS, Faculties of Medicine and Agriculture and Food Sciences, Université Laval, Quebéc, QC G1V 0A6, Canada |
| authorships[8].institutions[0].id | https://openalex.org/I43406934 |
| authorships[8].institutions[0].ror | https://ror.org/04sjchr03 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I43406934 |
| authorships[8].institutions[0].country_code | CA |
| authorships[8].institutions[0].display_name | Université Laval |
| authorships[8].institutions[1].id | https://openalex.org/I4210147106 |
| authorships[8].institutions[1].ror | https://ror.org/03wyf0g15 |
| authorships[8].institutions[1].type | facility |
| authorships[8].institutions[1].lineage | https://openalex.org/I4210147106 |
| authorships[8].institutions[1].country_code | IT |
| authorships[8].institutions[1].display_name | Istituto di Chimica Biomolecolare |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Vincenzo Di Marzo |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, CRIUCPQ and INAF-Centre NUTRISS, Faculties of Medicine and Agriculture and Food Sciences, Université Laval, Quebéc, QC G1V 0A6, Canada, Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy, Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[9].author.id | https://openalex.org/A5067672486 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-4263-3987 |
| authorships[9].author.display_name | Stefania Petrosino |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210147106 |
| authorships[9].affiliations[0].raw_affiliation_string | Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| authorships[9].affiliations[1].raw_affiliation_string | Epitech Group S.p.A., 35030 Saccolongo, Padova, Italy |
| authorships[9].affiliations[2].raw_affiliation_string | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy |
| authorships[9].institutions[0].id | https://openalex.org/I4210147106 |
| authorships[9].institutions[0].ror | https://ror.org/03wyf0g15 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210147106 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | Istituto di Chimica Biomolecolare |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Stefania Petrosino |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Endocannabinoid Research Group, 80078 Pozzuoli, Napoli, Italy, Epitech Group S.p.A., 35030 Saccolongo, Padova, Italy, Istituto di Chimica Biomolecolare, CNR, 80078 Pozzuoli, Napoli, Italy |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2073-4409/10/2/450/pdf?version=1614242368 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10414 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2736 |
| primary_topic.subfield.display_name | Pharmacology |
| primary_topic.display_name | Cannabis and Cannabinoid Research |
| related_works | https://openalex.org/W4226479235, https://openalex.org/W2334470388, https://openalex.org/W2281887241, https://openalex.org/W2333600510, https://openalex.org/W4221117701, https://openalex.org/W2013659300, https://openalex.org/W3047177116, https://openalex.org/W1986072332, https://openalex.org/W4324128500, https://openalex.org/W2139389244 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 2 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/cells10020450 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2736626452 |
| best_oa_location.source.issn | 2073-4409 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2073-4409 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Cells |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2073-4409/10/2/450/pdf?version=1614242368 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cells |
| best_oa_location.landing_page_url | https://doi.org/10.3390/cells10020450 |
| primary_location.id | doi:10.3390/cells10020450 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2736626452 |
| primary_location.source.issn | 2073-4409 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2073-4409 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Cells |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2073-4409/10/2/450/pdf?version=1614242368 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cells |
| primary_location.landing_page_url | https://doi.org/10.3390/cells10020450 |
| publication_date | 2021-02-20 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W1971715564, https://openalex.org/W6703288724, https://openalex.org/W2005694755, https://openalex.org/W1977298904, https://openalex.org/W2088956398, https://openalex.org/W2058373920, https://openalex.org/W2514974009, https://openalex.org/W1994127033, https://openalex.org/W1984319908, https://openalex.org/W2113319670, https://openalex.org/W1972207851, https://openalex.org/W2010129998, https://openalex.org/W2061301719, https://openalex.org/W2062256660, https://openalex.org/W1498357119, https://openalex.org/W2090706382, https://openalex.org/W1993081857, https://openalex.org/W2295932321, https://openalex.org/W3112803337, https://openalex.org/W2167845627, https://openalex.org/W1969338731, https://openalex.org/W2065648126, https://openalex.org/W2165128851, https://openalex.org/W2402802071, https://openalex.org/W1819429514, https://openalex.org/W1744763481, https://openalex.org/W2072596374, https://openalex.org/W2596523885, https://openalex.org/W4240370181, https://openalex.org/W2997165255, https://openalex.org/W2075894678, https://openalex.org/W2056188558, https://openalex.org/W1989073099, https://openalex.org/W1488329806, https://openalex.org/W2053029537, https://openalex.org/W1998612393, https://openalex.org/W2104980609, https://openalex.org/W1872852415, https://openalex.org/W2791222964, https://openalex.org/W6713526313, https://openalex.org/W598568091, https://openalex.org/W2012658698, https://openalex.org/W2624064951, https://openalex.org/W2038626534, https://openalex.org/W1967200224, https://openalex.org/W2064713996, https://openalex.org/W2007542364, https://openalex.org/W2061802741, https://openalex.org/W2336975059, https://openalex.org/W2325674352, https://openalex.org/W2159743040, https://openalex.org/W2158881850, https://openalex.org/W2326103119, https://openalex.org/W2599042840, https://openalex.org/W2056416370, https://openalex.org/W1982291289, https://openalex.org/W2973863905, https://openalex.org/W4254752226, https://openalex.org/W1531212045, https://openalex.org/W2122605977, https://openalex.org/W2131051512 |
| referenced_works_count | 61 |
| abstract_inverted_index.1 | 87 |
| abstract_inverted_index.2 | 99 |
| abstract_inverted_index.a | 9, 21, 130 |
| abstract_inverted_index.In | 13 |
| abstract_inverted_index.an | 3 |
| abstract_inverted_index.as | 109, 111 |
| abstract_inverted_index.at | 114 |
| abstract_inverted_index.in | 52, 55, 67, 117 |
| abstract_inverted_index.is | 2, 129 |
| abstract_inverted_index.it | 106 |
| abstract_inverted_index.of | 43, 64, 71, 143 |
| abstract_inverted_index.to | 60, 91, 134 |
| abstract_inverted_index.we | 16 |
| abstract_inverted_index.PEA | 25, 45, 72, 113 |
| abstract_inverted_index.The | 34 |
| abstract_inverted_index.and | 8, 19, 29, 47, 54, 73, 79, 105, 139 |
| abstract_inverted_index.for | 40 |
| abstract_inverted_index.its | 41 |
| abstract_inverted_index.the | 61, 74, 125, 137 |
| abstract_inverted_index.was | 38, 107 |
| abstract_inverted_index.(the | 26, 32 |
| abstract_inverted_index.PEA, | 65 |
| abstract_inverted_index.PEA. | 144 |
| abstract_inverted_index.able | 133 |
| abstract_inverted_index.acid | 31, 120 |
| abstract_inverted_index.both | 51 |
| abstract_inverted_index.from | 102 |
| abstract_inverted_index.mice | 122 |
| abstract_inverted_index.same | 62, 126 |
| abstract_inverted_index.this | 14 |
| abstract_inverted_index.type | 86 |
| abstract_inverted_index.used | 11 |
| abstract_inverted_index.when | 123 |
| abstract_inverted_index.(PEA) | 1 |
| abstract_inverted_index.dose. | 127 |
| abstract_inverted_index.drug) | 28 |
| abstract_inverted_index.lipid | 6 |
| abstract_inverted_index.mimic | 136 |
| abstract_inverted_index.named | 36 |
| abstract_inverted_index.novel | 131 |
| abstract_inverted_index.using | 124 |
| abstract_inverted_index.vitro | 53 |
| abstract_inverted_index.vivo. | 56 |
| abstract_inverted_index.GLUPEA | 57, 93, 128 |
| abstract_inverted_index.active | 27 |
| abstract_inverted_index.almost | 108 |
| abstract_inverted_index.higher | 68 |
| abstract_inverted_index.levels | 46 |
| abstract_inverted_index.study, | 15 |
| abstract_inverted_index.tested | 20 |
| abstract_inverted_index.widely | 10 |
| abstract_inverted_index.(2-AG), | 78 |
| abstract_inverted_index.(MCP-2) | 100 |
| abstract_inverted_index.(TRPV1) | 88 |
| abstract_inverted_index.GLUPEA, | 37 |
| abstract_inverted_index.actions | 142 |
| abstract_inverted_index.amounts | 70 |
| abstract_inverted_index.between | 24 |
| abstract_inverted_index.channel | 89 |
| abstract_inverted_index.colitis | 116 |
| abstract_inverted_index.protein | 98 |
| abstract_inverted_index.release | 101 |
| abstract_inverted_index.activity | 50 |
| abstract_inverted_index.cellular | 69 |
| abstract_inverted_index.compared | 59 |
| abstract_inverted_index.exerting | 48 |
| abstract_inverted_index.glycerol | 77 |
| abstract_inverted_index.mediator | 7 |
| abstract_inverted_index.monocyte | 96 |
| abstract_inverted_index.pro-drug | 132 |
| abstract_inverted_index.receptor | 83 |
| abstract_inverted_index.reducing | 115 |
| abstract_inverted_index.resulted | 66 |
| abstract_inverted_index.sulfonic | 119 |
| abstract_inverted_index.carrier). | 33 |
| abstract_inverted_index.conjugate | 23 |
| abstract_inverted_index.designed, | 17 |
| abstract_inverted_index.enhancing | 141 |
| abstract_inverted_index.increased | 80 |
| abstract_inverted_index.inhibited | 94 |
| abstract_inverted_index.potential | 84 |
| abstract_inverted_index.realized, | 18 |
| abstract_inverted_index.transient | 82 |
| abstract_inverted_index.vanilloid | 85 |
| abstract_inverted_index.capability | 42 |
| abstract_inverted_index.capsaicin. | 92 |
| abstract_inverted_index.conjugate, | 35 |
| abstract_inverted_index.endogenous | 4 |
| abstract_inverted_index.glucuronic | 30 |
| abstract_inverted_index.increasing | 44 |
| abstract_inverted_index.stimulated | 103 |
| abstract_inverted_index.treatment, | 58 |
| abstract_inverted_index.efficacious | 110 |
| abstract_inverted_index.efficiently | 135 |
| abstract_inverted_index.2-AG-induced | 81 |
| abstract_inverted_index.drug-carrier | 22 |
| abstract_inverted_index.characterized | 39 |
| abstract_inverted_index.concentration | 63 |
| abstract_inverted_index.2-arachidonoyl | 76 |
| abstract_inverted_index.dinitrobenzene | 118 |
| abstract_inverted_index.keratinocytes, | 104 |
| abstract_inverted_index.nutraceutical. | 12 |
| abstract_inverted_index.(DNBS)-injected | 121 |
| abstract_inverted_index.chemoattractant | 97 |
| abstract_inverted_index.desensitization | 90 |
| abstract_inverted_index.endocannabinoid | 75, 140 |
| abstract_inverted_index.pro-inflammatory | 95 |
| abstract_inverted_index.ultra-micronized | 112 |
| abstract_inverted_index.anti-inflammatory | 5, 49, 138 |
| abstract_inverted_index.Palmitoylethanolamide | 0 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5067672486, https://openalex.org/A5007484138 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I4210147106, https://openalex.org/I43406934 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5099999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.69030384 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |