A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo Article Swipe
Leticia Olivera‐Castillo
,
George Grant
,
Nuvia Kantún-Moreno
,
Hirian Alonso Moshe Barrera-Perez
,
Jorge Montero
,
Miguel Á. Olvera‐Novoa
,
Leydi Maribel Carrillo‐Cocom
,
Juan José Acevedo‐Fernández
,
Cesar Puerto-Castillo
,
Victor May Solís
,
Juan Antonio Pérez-Vega
,
Judit Gil‐Zamorano
,
Enrique Hernández-Garibay
,
María A. Fernández‐Herrera
,
Mayra Pérez-Tapia
,
Óscar Medina‐Contreras
,
Jairo R. Villanueva-Toledo
,
Rossanna Rodríguez‐Canul
,
Alberto Dávalos
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/nu12061698
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/nu12061698
Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. We have now screened some of its constituents for anti-inflammatory activity in vitro. Glycosaminoglycan and soluble protein preparations reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in HaCaT cells while an ethanol extract had a limited effect. The primary glycosaminoglycan (fucosylated chondroitin sulfate; FCS) was purified and tested for anti-inflammatory activity in vivo. FCS modulated the expression of critical genes, including NF-ĸB, TNFα, iNOS, and COX-2, and attenuated inflammation and tissue damage caused by TPA in a mouse ear inflammation model. It also mitigated colonic colitis caused in mice by dextran sodium sulfate. FCS from I. badionotus of the Yucatan Peninsula thus had strong anti-inflammatory properties in vivo.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/nu12061698
- https://www.mdpi.com/2072-6643/12/6/1698/pdf?version=1591436518
- OA Status
- gold
- Cited By
- 28
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3033842758
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3033842758Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/nu12061698Digital Object Identifier
- Title
-
A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In VivoWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-06-06Full publication date if available
- Authors
-
Leticia Olivera‐Castillo, George Grant, Nuvia Kantún-Moreno, Hirian Alonso Moshe Barrera-Perez, Jorge Montero, Miguel Á. Olvera‐Novoa, Leydi Maribel Carrillo‐Cocom, Juan José Acevedo‐Fernández, Cesar Puerto-Castillo, Victor May Solís, Juan Antonio Pérez-Vega, Judit Gil‐Zamorano, Enrique Hernández-Garibay, María A. Fernández‐Herrera, Mayra Pérez-Tapia, Óscar Medina‐Contreras, Jairo R. Villanueva-Toledo, Rossanna Rodríguez‐Canul, Alberto DávalosList of authors in order
- Landing page
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https://doi.org/10.3390/nu12061698Publisher landing page
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https://www.mdpi.com/2072-6643/12/6/1698/pdf?version=1591436518Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2072-6643/12/6/1698/pdf?version=1591436518Direct OA link when available
- Concepts
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Glycosaminoglycan, In vivo, In vitro, Anti-inflammatory, Chemistry, Pharmacology, Biochemistry, Biology, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
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28Total citation count in OpenAlex
- Citations by year (recent)
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2025: 7, 2024: 7, 2023: 5, 2022: 3, 2021: 6Per-year citation counts (last 5 years)
- References (count)
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45Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.anti-inflammatory | 39, 52, 89, 144 |
| abstract_inverted_index.glycosaminoglycan | 79 |
| abstract_inverted_index.12-O-tetradecanoylphorbol-13-acetate | 62 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5055147698, https://openalex.org/A5011255584 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 19 |
| corresponding_institution_ids | https://openalex.org/I105140100, https://openalex.org/I4210143378, https://openalex.org/I59361560, https://openalex.org/I63634437, https://openalex.org/I68368234 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/14 |
| sustainable_development_goals[0].score | 0.8799999952316284 |
| sustainable_development_goals[0].display_name | Life below water |
| citation_normalized_percentile.value | 0.89865781 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |