A handheld bioprinter for multi-material printing of complex constructs Article Swipe
Erik Pagan
,
Evan Stefanek
,
Amir Seyfoori
,
Mahmood Razzaghi
,
Behnad Chehri
,
Ali Mousavi
,
Pietro Arnaldi
,
Zineb Ajji
,
Daniela Ravizzoni Dartora
,
Seyed Mohammad Hossein Dabiri
,
Anne Monique Nuyt
,
Ali Khademhosseini
,
Houman Savoji
,
Mohsen Akbari
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1088/1758-5090/acc42c
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1088/1758-5090/acc42c
In situ bioprinting—the process of depositing bioinks at a defected area, has recently emerged as a versatile technology for tissue repair and restoration via site-specific delivery of pro-healing constructs. The ability to print multiple materials in situ is an exciting approach that allows simultaneous or sequential dispensing of different materials and cells to achieve tissue biomimicry. Herein, we report a modular handheld bioprinter that deposits a variety of bioinks in situ with exquisite control over their physical and chemical properties. Combined stereolithography 3D printing and microfluidic technologies allowed us to develop a novel low-priced handheld bioprinter. The ergonomic design of the handheld bioprinter facilitate the shape-controlled biofabrication of multi-component fibers with different cross-sectional shapes and material compositions. Furthermore, the capabilities of the produced fibers in the local delivery of therapeutic agents was demonstrated by incorporating drug-loaded microcarriers, extending the application of the printed fibers to on-demand, temporal, and dosage-control drug delivery platforms. Also, the versatility of this platform to produce biosensors and wearable electronics was demonstrated via incorporating conductive materials and integrating pH-responsive dyes. The handheld printer’s efficacy in generating cell-laden fibers with high cell viability for site-specific cell delivery was shown by producing single-component and multi-component cell-laden fibers. In particular, the multi-component fibers were able to model the invasion of cancer cells into the adjacent tissue.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1088/1758-5090/acc42c
- https://iopscience.iop.org/article/10.1088/1758-5090/acc42c/pdf
- OA Status
- hybrid
- Cited By
- 29
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4324131326
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4324131326Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1088/1758-5090/acc42cDigital Object Identifier
- Title
-
A handheld bioprinter for multi-material printing of complex constructsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-14Full publication date if available
- Authors
-
Erik Pagan, Evan Stefanek, Amir Seyfoori, Mahmood Razzaghi, Behnad Chehri, Ali Mousavi, Pietro Arnaldi, Zineb Ajji, Daniela Ravizzoni Dartora, Seyed Mohammad Hossein Dabiri, Anne Monique Nuyt, Ali Khademhosseini, Houman Savoji, Mohsen AkbariList of authors in order
- Landing page
-
https://doi.org/10.1088/1758-5090/acc42cPublisher landing page
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https://iopscience.iop.org/article/10.1088/1758-5090/acc42c/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://iopscience.iop.org/article/10.1088/1758-5090/acc42c/pdfDirect OA link when available
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Mobile device, Materials science, 3D printing, Computer science, Operating system, Composite materialTop concepts (fields/topics) attached by OpenAlex
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29Total citation count in OpenAlex
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2025: 12, 2024: 14, 2023: 3Per-year citation counts (last 5 years)
- References (count)
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49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.value | 0.93896205 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |