Abstract Artificial intelligence (AI) applications are having increasing impacts in the biomedical sciences. Modern AI tools enable uncovering hidden patterns in large datasets, forecasting outcomes, and numerous other applications. Despite the availability and power of these tools, the rapid expansion and complexity of AI applications can be daunting, and there is a conspicuous absence of consensus on their ethical and responsible use. Misapplication of AI can result in invalid, unclear, or biased outcomes, exace…