A High-Throughput Data-Independent Acquisition Workflow for Deep Characterisation of thesn-Isomer Lipidome Article Swipe
Jesse A. Michael
,
Reuben S. E. Young
,
Rachelle Balez
,
Lachlan J. Jekimovs
,
David L. Marshall
,
Berwyck L. J. Poad
,
Todd W. Mitchell
,
Stephen J. Blanksby
,
Christer S. Ejsing
,
Shane R. Ellis
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.11.04.565044
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.11.04.565044
We report a workflow based on ozone-induced dissociation for untargeted characterization of hundreds of sn- resolved glycerophospholipid isomers from biological extracts in under 20 minutes, coupled with an automated data analysis pipeline. It provides an order of magnitude increase in the number of sn- isomer pairs identified compared to previous reports, reveals that sn -isomer populations are tightly regulated and significantly different between cell lines, and enables identification of rare lipids containing ultra-long chain monounsaturated acyl chains.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.11.04.565044
- https://www.biorxiv.org/content/biorxiv/early/2023/11/05/2023.11.04.565044.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388373551
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388373551Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.11.04.565044Digital Object Identifier
- Title
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A High-Throughput Data-Independent Acquisition Workflow for Deep Characterisation of thesn-Isomer LipidomeWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-11-05Full publication date if available
- Authors
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Jesse A. Michael, Reuben S. E. Young, Rachelle Balez, Lachlan J. Jekimovs, David L. Marshall, Berwyck L. J. Poad, Todd W. Mitchell, Stephen J. Blanksby, Christer S. Ejsing, Shane R. EllisList of authors in order
- Landing page
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https://doi.org/10.1101/2023.11.04.565044Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2023/11/05/2023.11.04.565044.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2023/11/05/2023.11.04.565044.full.pdfDirect OA link when available
- Concepts
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Lipidome, Glycerophospholipid, Workflow, Chemistry, Pipeline (software), Dissociation (chemistry), Computational biology, Lipidomics, Computer science, Biochemistry, Biology, Database, Phospholipid, Organic chemistry, Programming language, MembraneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
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33Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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