A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium Article Swipe
Caridad Miró-Pina
,
Olivier Arnaiz
,
Augustin de Vanssay
,
Andrea Frapporti
,
Olivia Charmant
,
Adeline Humbert
,
Maoussi Lhuillier‐Akakpo
,
Sandra Duharcourt
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.07.04.547679
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.07.04.547679
To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20-30 nucleotides in length, bind to PIWI proteins and guide them to nascent transcripts by sequence complementarity, triggering the recruitment of histone methyltransferase enzymes on chromatin to repress the transcriptional activity of TEs and other repeats. In the ciliate Paramecium tetraurelia , 25-nt scnRNAs corresponding to TEs recruit Polycomb Repressive Complex 2 (PRC2), and trigger their elimination during the formation of the somatic nucleus. Here, we sequenced sRNAs during the entire sexual cycle with unprecedented resolution. Our data confirmed that scnRNAs are produced from the entire germline genome, from TEs and non-TE sequences, during meiosis. Non-TE scnRNAs are selectively degraded, which results in the specific selection of TE-scnRNAs. We demonstrate that PRC2 is essential for the selective degradation of non-TE-scnRNAs, independently of its histone methyltransferase activity. We further show that the PRC2 cofactor Rf4 is required for the physical interaction between the scnRNA-binding protein Ptiwi09 and the zinc finger protein Gtsf1, pointing to an architectural role of PRC2 in scnRNA degradation.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.07.04.547679
- https://www.biorxiv.org/content/biorxiv/early/2023/07/04/2023.07.04.547679.full.pdf
- OA Status
- green
- Cited By
- 4
- References
- 59
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4383106836
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4383106836Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.07.04.547679Digital Object Identifier
- Title
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A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in ParameciumWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-07-04Full publication date if available
- Authors
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Caridad Miró-Pina, Olivier Arnaiz, Augustin de Vanssay, Andrea Frapporti, Olivia Charmant, Adeline Humbert, Maoussi Lhuillier‐Akakpo, Sandra DuharcourtList of authors in order
- Landing page
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https://doi.org/10.1101/2023.07.04.547679Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2023/07/04/2023.07.04.547679.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2023/07/04/2023.07.04.547679.full.pdfDirect OA link when available
- Concepts
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PRC2, Biology, Genetics, Chromatin, Transposable element, Genome, RNA, Cell biology, Histone H3, DNA, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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59Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I1294671590, https://openalex.org/I204730241, https://openalex.org/I4210113761 |
| citation_normalized_percentile.value | 0.72784764 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |