A hybrid effectiveness-implementation study protocol to assess the effectiveness and chemoprevention efficacy of implementing seasonal malaria chemoprevention in five districts in Karamoja region, Uganda Article Swipe
Richard Kajubi
,
Jennifer Ainsworth
,
K. Scott Baker
,
Sol Richardson
,
Craig Bonnington
,
Christian Rassi
,
Jane Achan
,
Godfrey Magumba
,
Denis Rubahika
,
Jane Nabakooza
,
James Tibenderana
,
Anthony Nuwa
,
Jimmy Opigo
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.12688/gatesopenres.14287.2
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.12688/gatesopenres.14287.2
Background The World Health Organization (WHO) recommends seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SPAQ) for children aged 3 to 59 months, living in areas where malaria transmission is highly seasonal. However, due to widespread prevalence of resistance markers, SMC has not been implemented at scale in East and Southern Africa. An initial study in Uganda showed that SMC with SPAQ was feasible, acceptable, and protective against malaria in eligible children in Karamoja region. Nonetheless, exploration of alternative regimens is warranted since parasite resistance threats persist. Objective The study aims to test the effectiveness of SMC with Dihydroartemisinin-piperaquine (DP) or SPAQ (DP-SMC & SPAQ-SMC), chemoprevention efficacy as well as the safety and tolerability of DP compared to that of SPAQ among 3-59 months old children in Karamoja region, an area of Uganda where malaria transmission is highly seasonal. Methods A Type II hybrid effectiveness-implementation study design consisting of four components: 1) a cluster randomized controlled trial (cRCT) using passive surveillance to establish confirmed malaria cases in children using both SPAQ and DP; 2a) a prospective cohort study to determine the chemoprevention efficacy of SPAQ and DP (if SPAQ or DP clears sub-patent infection and provides 28 days of protection from new infection) and whether drug concentrations and/or resistance influence the ability to clear and prevent infection; 2b) a sub study examining pharmacokinetics of DP in children between 3 to
Related Topics
Concepts
Malaria
Amodiaquine
Medicine
Sulfadoxine
Population
Environmental health
Pyrimethamine
Plasmodium falciparum
Immunology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.12688/gatesopenres.14287.2
- OA Status
- gold
- Cited By
- 4
- References
- 16
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389918502
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4389918502Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.12688/gatesopenres.14287.2Digital Object Identifier
- Title
-
A hybrid effectiveness-implementation study protocol to assess the effectiveness and chemoprevention efficacy of implementing seasonal malaria chemoprevention in five districts in Karamoja region, UgandaWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-18Full publication date if available
- Authors
-
Richard Kajubi, Jennifer Ainsworth, K. Scott Baker, Sol Richardson, Craig Bonnington, Christian Rassi, Jane Achan, Godfrey Magumba, Denis Rubahika, Jane Nabakooza, James Tibenderana, Anthony Nuwa, Jimmy OpigoList of authors in order
- Landing page
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https://doi.org/10.12688/gatesopenres.14287.2Publisher landing page
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://doi.org/10.12688/gatesopenres.14287.2Direct OA link when available
- Concepts
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Malaria, Amodiaquine, Medicine, Sulfadoxine, Population, Environmental health, Pyrimethamine, Plasmodium falciparum, ImmunologyTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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16Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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