A Gata3 enhancer necessary for ILC2 development and function Article Swipe
Darshan N. Kasal
,
Zhitao Liang
,
Maile K. Hollinger
,
Crystal Y. O’Leary
,
Wioletta Lisicka
,
Anne I. Sperling
,
Albert Bendelac
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2106311118
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2106311118
Significance Group 2 innate lymphoid cells (ILC2s) and adaptive CD4 + T helper type 2 (Th2) cells express a common effector program orchestrated by the “master” transcription factor GATA3 that is acquired through development or differentiation, respectively. To elucidate the regulatory mechanisms controlling the acquisition of this shared program, we used a combination of chromatin accessibility data and CRISPR/Cas9-mediated deletion, which revealed a Gata3 enhancer necessary for ILC2 development and function. Notably, this enhancer was largely dispensable for Th2 cell differentiation. Thus, ILC2s and Th2 cells display different requirements for the induction of a common type 2 helper effector program.
Related Topics
Concepts
Enhancer
GATA3
Innate lymphoid cell
Biology
Effector
Transcription factor
CRISPR
Chromatin
Function (biology)
Cell biology
Computational biology
Genetics
Acquired immune system
Gene
Antigen
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2106311118
- https://www.pnas.org/content/pnas/118/32/e2106311118.full.pdf
- OA Status
- bronze
- Cited By
- 34
- References
- 88
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3191478634
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3191478634Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1073/pnas.2106311118Digital Object Identifier
- Title
-
A Gata3 enhancer necessary for ILC2 development and functionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-05Full publication date if available
- Authors
-
Darshan N. Kasal, Zhitao Liang, Maile K. Hollinger, Crystal Y. O’Leary, Wioletta Lisicka, Anne I. Sperling, Albert BendelacList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.2106311118Publisher landing page
- PDF URL
-
https://www.pnas.org/content/pnas/118/32/e2106311118.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
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https://www.pnas.org/content/pnas/118/32/e2106311118.full.pdfDirect OA link when available
- Concepts
-
Enhancer, GATA3, Innate lymphoid cell, Biology, Effector, Transcription factor, CRISPR, Chromatin, Function (biology), Cell biology, Computational biology, Genetics, Acquired immune system, Gene, AntigenTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
34Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 11, 2023: 6, 2022: 5, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
88Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 93 |
| corresponding_author_ids | https://openalex.org/A5023002972 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I40347166 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/17 |
| sustainable_development_goals[0].score | 0.41999998688697815 |
| sustainable_development_goals[0].display_name | Partnerships for the goals |
| citation_normalized_percentile.value | 0.87270563 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |