A joint frailty model for recurrent and competing terminal events: Application to delirium in the ICU Article Swipe
Lacey Etzkorn
,
Quentin Le Coënt
,
Mark van den Boogaard
,
Virginie Rondeau
,
Elizabeth Colantuoni
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/sim.10053
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/sim.10053
Joint models linking longitudinal biomarkers or recurrent event processes with a terminal event, for example, mortality, have been studied extensively. Motivated by studies of recurrent delirium events in patients receiving care in an intensive care unit (ICU), we devise a joint model for a recurrent event process and multiple terminal events. Being discharged alive from the ICU or experiencing mortality may be associated with a patient's hazard of delirium, violating the assumption of independent censoring. Moreover, the direction of the association between the hazards of delirium and mortality may be opposite of the direction of association between the hazards of delirium and ICU discharge. Hence treating either terminal event as independent censoring may bias inferences. We propose a competing joint model that uses a latent frailty to link a patient's recurrent and competing terminal event processes. We fit our model to data from a completed placebo‐controlled clinical trial, which studied whether Haloperidol could prevent death and delirium among ICU patients. The clinical trial served as a foundation for a simulation study, in which we evaluate the properties, for example, bias and confidence interval coverage, of the competing joint model. As part of the simulation study, we demonstrate the shortcomings of using a joint model with a recurrent delirium process and a single terminal event to study delirium in the ICU. Lastly, we discuss limitations and possible extensions for the competing joint model. The competing joint model has been added to frailtypack , an R package for fitting an assortment of joint models.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/sim.10053
- OA Status
- green
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393542020
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393542020Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/sim.10053Digital Object Identifier
- Title
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A joint frailty model for recurrent and competing terminal events: Application to delirium in the ICUWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-02Full publication date if available
- Authors
-
Lacey Etzkorn, Quentin Le Coënt, Mark van den Boogaard, Virginie Rondeau, Elizabeth ColantuoniList of authors in order
- Landing page
-
https://doi.org/10.1002/sim.10053Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11258962Direct OA link when available
- Concepts
-
Censoring (clinical trials), Delirium, Proportional hazards model, Intensive care unit, Event (particle physics), Medicine, Hazard ratio, Confidence interval, Intensive care medicine, Internal medicine, Quantum mechanics, Physics, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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22Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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