A low level of CD16pos monocytes in SARS-CoV-2 infected patients is a marker of severity Article Swipe
Marc Vasse
,
Benjamin Zuber
,
Laurie Goubeau
,
Marie‐Christine Ballester
,
Mathilde Roumier
,
Frédérique Delcominette
,
Florence Habarou
,
Émilie Jolly
,
Félix Ackermann
,
Charles Cerf
,
Éric Farfour
,
Tiffany Pascreau
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1515/cclm-2020-1801
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1515/cclm-2020-1801
Objectives Severe forms of coronavirus disease 2019 (COVID-19) are characterized by an excessive production of inflammatory cytokines. Activated monocytes secrete high levels of cytokines. Human monocytes are divided into three major populations: conventional (CD14 pos CD16 neg ), non-classical (CD14 dim CD16 pos ), and intermediate (CD14 pos CD16 pos ) monocytes. The aim of this study was to analyze whether the distribution of conventional (CD16 neg ) and CD16 pos monocytes is different in patients with COVID-19 and whether the variations could be predictive of the outcome of the disease. Methods We performed a prospective study on 390 consecutive patients referred to the Emergency Unit, with a proven diagnosis of SARS-CoV 2 infection by RT-PCR. Using the CytoDiff™ reagent, an automated routine leukocyte differential, we quantified CD16 neg and CD16 pos monocytes. Results In the entire population, median CD16 neg and CD16 pos monocyte levels (0.398 and 0.054×10 9 /L, respectively) were in the normal range [(0.3–0.7×10 9 /L) and (0.015–0.065×10 9 /L), respectively], but the 35 patients in the intensive care unit (ICU) had a significantly (p<0.001) lower CD16 pos monocyte count (0.018 × 10 9 /L) in comparison to the 70 patients who were discharged (0.064 × 10 9 /L) or were hospitalized in conventional units (0.058 × 10 9 /L). By ROC curve analysis, the ratio [absolute neutrophil count/CD16 pos monocyte count] was highly discriminant to identify patients requiring ICU hospitalization: with a cut-off 193.1, the sensitivity and the specificity were 74.3 and 81.8%, respectively (area under the curve=0.817). Conclusions Quantification of CD16 pos monocytes and the ratio [absolute neutrophil count/CD16 pos monocyte count] could constitute a marker of the severity of disease in COVID-19 patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1515/cclm-2020-1801
- https://www.degruyter.com/document/doi/10.1515/cclm-2020-1801/pdf?licenseType=free
- OA Status
- bronze
- Cited By
- 8
- References
- 41
- Related Works
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- OpenAlex ID
- https://openalex.org/W3132445051
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3132445051Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1515/cclm-2020-1801Digital Object Identifier
- Title
-
A low level of CD16pos monocytes in SARS-CoV-2 infected patients is a marker of severityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
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2021-02-20Full publication date if available
- Authors
-
Marc Vasse, Benjamin Zuber, Laurie Goubeau, Marie‐Christine Ballester, Mathilde Roumier, Frédérique Delcominette, Florence Habarou, Émilie Jolly, Félix Ackermann, Charles Cerf, Éric Farfour, Tiffany PascreauList of authors in order
- Landing page
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https://doi.org/10.1515/cclm-2020-1801Publisher landing page
- PDF URL
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https://www.degruyter.com/document/doi/10.1515/cclm-2020-1801/pdf?licenseType=freeDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.degruyter.com/document/doi/10.1515/cclm-2020-1801/pdf?licenseType=freeDirect OA link when available
- Concepts
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CD16, CD14, Medicine, Monocyte, Intensive care unit, Immunology, Gastroenterology, Internal medicine, Intensive care, Flow cytometry, Antigen, CD3, Intensive care medicine, CD8Top concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2023: 3, 2022: 3, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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