A map of signaling responses in the human airway epithelium Article Swipe
Katherine B. McCauley
,
Kalki Kukreja
,
Aron B. Jaffe
,
Allon M. Klein
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.12.21.521460
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.12.21.521460
Receptor-mediated signaling plays a central role in tissue regeneration, and it is dysregulated in disease. Here, we build a signaling–response map for a model regenerative human tissue: the airway epithelium. We analyzed the effect of 17 receptor-mediated signaling pathways on organotypic cultures to determine changes in abundance and phenotype of all epithelial cell types. This map recapitulates the gamut of known airway epithelial signaling responses to these pathways. It defines convergent states induced by multiple ligands and diverse, ligand-specific responses in basal-cell and secretory-cell metaplasia. We show that loss of canonical differentiation induced by multiple pathways is associated with cell cycle arrest, but that arrest is not sufficient to block differentiation. Using the signaling-response map, we show that a TGFB1-mediated response underlies specific aberrant cells found in multiple lung diseases and identify interferon responses in COVID-19 patient samples. Thus, we offer a framework enabling systematic evaluation of tissue signaling responses.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.12.21.521460
- https://www.biorxiv.org/content/biorxiv/early/2022/12/22/2022.12.21.521460.full.pdf
- OA Status
- green
- References
- 104
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4312197789
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4312197789Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2022.12.21.521460Digital Object Identifier
- Title
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A map of signaling responses in the human airway epitheliumWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-12-22Full publication date if available
- Authors
-
Katherine B. McCauley, Kalki Kukreja, Aron B. Jaffe, Allon M. KleinList of authors in order
- Landing page
-
https://doi.org/10.1101/2022.12.21.521460Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/12/22/2022.12.21.521460.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2022/12/22/2022.12.21.521460.full.pdfDirect OA link when available
- Concepts
-
Biology, Signal transduction, Cell biology, Epithelium, Respiratory epithelium, Cell signaling, Cell, Regeneration (biology), Phenotype, Immunology, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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104Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| publication_year | 2022 |
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| abstract_inverted_index.the | 27, 32, 57, 112 |
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