A mcr-1-Carrying Conjugative IncX4 Plasmid in Colistin-Resistant Escherichia coli ST278 Strain Isolated From Dairy Cow Feces in Shanghai, China Article Swipe
Fengjia Bai
,
Xiaobin Li
,
Ben Niu
,
Zhaohuan Zhang
,
Pradeep K. Malakar
,
Haiquan Liu
,
Yingjie Pan
,
Yong Zhao
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2018.02833
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2018.02833
Enterobacteriaceae, including Escherichia coli, has been shown to acquire the colistin resistance gene mcr-1. A strain of E. coli, EC11, which is resistant to colistin, polymyxin B and trimethoprim-sulfamethoxazole, was isolated in 2016 from the feces of a dairy cow in Shanghai, China. Strain EC11 identifies with sequence type ST278 and is susceptible to 19 frequently used antibiotics. Whole genome sequencing of strain EC11 showed that this strain contains a 31-kb resistance plasmid, pEC11b, which belongs to the IncX4 group. The mcr-1 gene was shown to be inserted into a 2.6-kb mcr-1-pap2 cassette of pEC11b. Plasmid pEC11b also contained putative conjugal transfer components, including an oriT-like region, relaxase, type IV coupling protein, and type IV secretion system. We were successful in transferring pEC11b to E. coli C600 with an average transconjugation efficiency of 4.6 × 10-5. Additionally, a MLST-based analysis comparing EC11 and other reported mcr-positive E. coli populations showed high genotypic diversity. The discovery of the E. coli strain EC11 with resistance to colistin in Shanghai emphasizes the importance of vigilance in detecting new threats like mcr genes to public health. Detection of mcr genes helps in tracking, slowing, and responding to the emergence of antibiotic resistance in Chinese livestock farming.
Related Topics
Concepts
MCR-1
Colistin
Escherichia coli
Plasmid
Biology
Microbiology
Polymyxin
Antibiotic resistance
Strain (injury)
Multilocus sequence typing
Enterobacteriaceae
Gene
Genetics
Genotype
Antibiotics
Anatomy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2018.02833
- https://www.frontiersin.org/articles/10.3389/fmicb.2018.02833/pdf
- OA Status
- gold
- Cited By
- 25
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2902708397
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2902708397Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2018.02833Digital Object Identifier
- Title
-
A mcr-1-Carrying Conjugative IncX4 Plasmid in Colistin-Resistant Escherichia coli ST278 Strain Isolated From Dairy Cow Feces in Shanghai, ChinaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-11-30Full publication date if available
- Authors
-
Fengjia Bai, Xiaobin Li, Ben Niu, Zhaohuan Zhang, Pradeep K. Malakar, Haiquan Liu, Yingjie Pan, Yong ZhaoList of authors in order
- Landing page
-
https://doi.org/10.3389/fmicb.2018.02833Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmicb.2018.02833/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fmicb.2018.02833/pdfDirect OA link when available
- Concepts
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MCR-1, Colistin, Escherichia coli, Plasmid, Biology, Microbiology, Polymyxin, Antibiotic resistance, Strain (injury), Multilocus sequence typing, Enterobacteriaceae, Gene, Genetics, Genotype, Antibiotics, AnatomyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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25Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2, 2023: 6, 2022: 1, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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