A mechanism for matrikine regulation in acute inflammatory lung injury Article Swipe
Sarah W. Robison
,
JinDong Li
,
Liliana Viera
,
Jonathan P. Blackburn
,
Rakesh P. Patel
,
J. Edwin Blalock
,
Amit Gaggar
,
Xin Xu
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.140750
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.140750
Proline-glycine-proline (PGP) and its acetylated form (Ac-PGP) are neutrophil chemoattractants generated by collagen degradation, and they have been shown to play a role in chronic inflammatory disease. However, the mechanism for matrikine regulation in acute inflammation has not been well established. Here, we show that these peptides are actively transported from the lung by the oligopeptide transporter, PEPT2. Following intratracheal instillation of Ac-PGP in a mouse model, there was a rapid decline in concentration of the labeled peptide in the bronchoalveolar lavage (BAL) over time and redistribution to extrapulmonary sites. In vitro knockdown of the PEPT2 transporter in airway epithelia or use of a competitive inhibitor of PEPT2, cefadroxil, significantly reduced uptake of Ac-PGP. Animals that received intratracheal Ac-PGP plus cefadroxil had higher levels of Ac-PGP in BAL and lung tissue. Utilizing an acute LPS-induced lung injury model, we demonstrate that PEPT2 blockade enhanced pulmonary Ac-PGP levels and lung inflammation. We further validated this effect using clinical samples from patients with acute lung injury in coculture with airway epithelia. This is the first study to our knowledge to determine the in vitro and in vivo significance of active matrikine transport as a mechanism of modulating acute inflammation and to demonstrate that it may serve as a potential therapeutic target.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1172/jci.insight.140750
- http://insight.jci.org/articles/view/140750/files/pdf
- OA Status
- gold
- Cited By
- 11
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3146057888
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3146057888Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1172/jci.insight.140750Digital Object Identifier
- Title
-
A mechanism for matrikine regulation in acute inflammatory lung injuryWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-04-07Full publication date if available
- Authors
-
Sarah W. Robison, JinDong Li, Liliana Viera, Jonathan P. Blackburn, Rakesh P. Patel, J. Edwin Blalock, Amit Gaggar, Xin XuList of authors in order
- Landing page
-
https://doi.org/10.1172/jci.insight.140750Publisher landing page
- PDF URL
-
https://insight.jci.org/articles/view/140750/files/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://insight.jci.org/articles/view/140750/files/pdfDirect OA link when available
- Concepts
-
Bronchoalveolar lavage, Lung, Inflammation, In vivo, Pharmacology, Chemistry, In vitro, Medicine, Immunology, Biology, Internal medicine, Biochemistry, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 3, 2023: 4, 2022: 2Per-year citation counts (last 5 years)
- References (count)
-
45Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3146057888 |
|---|---|
| doi | https://doi.org/10.1172/jci.insight.140750 |
| ids.doi | https://doi.org/10.1172/jci.insight.140750 |
| ids.mag | 3146057888 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33830084 |
| ids.openalex | https://openalex.org/W3146057888 |
| fwci | 1.09186944 |
| mesh[0].qualifier_ui | Q000276 |
| mesh[0].descriptor_ui | D055371 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | immunology |
| mesh[0].descriptor_name | Acute Lung Injury |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000818 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Animals |
| mesh[2].qualifier_ui | Q000494 |
| mesh[2].descriptor_ui | D000900 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | pharmacology |
| mesh[2].descriptor_name | Anti-Bacterial Agents |
| mesh[3].qualifier_ui | Q000276 |
| mesh[3].descriptor_ui | D001693 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | immunology |
| mesh[3].descriptor_name | Biological Transport, Active |
| mesh[4].qualifier_ui | Q000276 |
| mesh[4].descriptor_ui | D000086382 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | immunology |
| mesh[4].descriptor_name | COVID-19 |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D000086382 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | COVID-19 |
| mesh[6].qualifier_ui | Q000494 |
| mesh[6].descriptor_ui | D002434 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | pharmacology |
| mesh[6].descriptor_name | Cefadroxil |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D002478 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Cells, Cultured |
| mesh[8].qualifier_ui | Q000276 |
| mesh[8].descriptor_ui | D002630 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | immunology |
| mesh[8].descriptor_name | Chemotactic Factors |
| mesh[9].qualifier_ui | Q000494 |
| mesh[9].descriptor_ui | D002630 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | pharmacology |
| mesh[9].descriptor_name | Chemotactic Factors |
| mesh[10].qualifier_ui | Q000276 |
| mesh[10].descriptor_ui | D002634 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | immunology |
| mesh[10].descriptor_name | Chemotaxis, Leukocyte |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D004195 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Disease Models, Animal |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D005109 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Extracellular Matrix |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D016326 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Extracellular Matrix Proteins |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D006801 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Humans |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D007249 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Inflammation |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D051379 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Mice |
| mesh[17].qualifier_ui | Q000276 |
| mesh[17].descriptor_ui | D009842 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | immunology |
| mesh[17].descriptor_name | Oligopeptides |
| mesh[18].qualifier_ui | Q000494 |
| mesh[18].descriptor_ui | D009842 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | pharmacology |
| mesh[18].descriptor_name | Oligopeptides |
| mesh[19].qualifier_ui | Q000031 |
| mesh[19].descriptor_ui | D011392 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | analogs & derivatives |
| mesh[19].descriptor_name | Proline |
| mesh[20].qualifier_ui | Q000276 |
| mesh[20].descriptor_ui | D011392 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | immunology |
| mesh[20].descriptor_name | Proline |
| mesh[21].qualifier_ui | Q000494 |
| mesh[21].descriptor_ui | D011392 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | pharmacology |
| mesh[21].descriptor_name | Proline |
| mesh[22].qualifier_ui | Q000037 |
| mesh[22].descriptor_ui | D027981 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | antagonists & inhibitors |
| mesh[22].descriptor_name | Symporters |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D027981 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Symporters |
| mesh[24].qualifier_ui | Q000276 |
| mesh[24].descriptor_ui | D055371 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | immunology |
| mesh[24].descriptor_name | Acute Lung Injury |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D000818 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Animals |
| mesh[26].qualifier_ui | Q000494 |
| mesh[26].descriptor_ui | D000900 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | pharmacology |
| mesh[26].descriptor_name | Anti-Bacterial Agents |
| mesh[27].qualifier_ui | Q000276 |
| mesh[27].descriptor_ui | D001693 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | immunology |
| mesh[27].descriptor_name | Biological Transport, Active |
| mesh[28].qualifier_ui | Q000276 |
| mesh[28].descriptor_ui | D000086382 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | immunology |
| mesh[28].descriptor_name | COVID-19 |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D000086382 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | COVID-19 |
| mesh[30].qualifier_ui | Q000494 |
| mesh[30].descriptor_ui | D002434 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | pharmacology |
| mesh[30].descriptor_name | Cefadroxil |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D002478 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Cells, Cultured |
| mesh[32].qualifier_ui | Q000276 |
| mesh[32].descriptor_ui | D002630 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | immunology |
| mesh[32].descriptor_name | Chemotactic Factors |
| mesh[33].qualifier_ui | Q000494 |
| mesh[33].descriptor_ui | D002630 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | pharmacology |
| mesh[33].descriptor_name | Chemotactic Factors |
| mesh[34].qualifier_ui | Q000276 |
| mesh[34].descriptor_ui | D002634 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | immunology |
| mesh[34].descriptor_name | Chemotaxis, Leukocyte |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D004195 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Disease Models, Animal |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D005109 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Extracellular Matrix |
| mesh[37].qualifier_ui | Q000378 |
| mesh[37].descriptor_ui | D016326 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | metabolism |
| mesh[37].descriptor_name | Extracellular Matrix Proteins |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D006801 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Humans |
| mesh[39].qualifier_ui | Q000378 |
| mesh[39].descriptor_ui | D007249 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | metabolism |
| mesh[39].descriptor_name | Inflammation |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D051379 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Mice |
| mesh[41].qualifier_ui | Q000276 |
| mesh[41].descriptor_ui | D009842 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | immunology |
| mesh[41].descriptor_name | Oligopeptides |
| mesh[42].qualifier_ui | Q000494 |
| mesh[42].descriptor_ui | D009842 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | pharmacology |
| mesh[42].descriptor_name | Oligopeptides |
| mesh[43].qualifier_ui | Q000031 |
| mesh[43].descriptor_ui | D011392 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | analogs & derivatives |
| mesh[43].descriptor_name | Proline |
| mesh[44].qualifier_ui | Q000276 |
| mesh[44].descriptor_ui | D011392 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | immunology |
| mesh[44].descriptor_name | Proline |
| mesh[45].qualifier_ui | Q000494 |
| mesh[45].descriptor_ui | D011392 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | pharmacology |
| mesh[45].descriptor_name | Proline |
| mesh[46].qualifier_ui | Q000037 |
| mesh[46].descriptor_ui | D027981 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | antagonists & inhibitors |
| mesh[46].descriptor_name | Symporters |
| mesh[47].qualifier_ui | Q000378 |
| mesh[47].descriptor_ui | D027981 |
| mesh[47].is_major_topic | True |
| mesh[47].qualifier_name | metabolism |
| mesh[47].descriptor_name | Symporters |
| type | article |
| title | A mechanism for matrikine regulation in acute inflammatory lung injury |
| awards[0].id | https://openalex.org/G2286930711 |
| awards[0].funder_id | https://openalex.org/F4320306230 |
| awards[0].display_name | |
| awards[0].funder_award_id | 16SDG27040000 |
| awards[0].funder_display_name | American Heart Association |
| biblio.issue | 7 |
| biblio.volume | 6 |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10814 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.9990000128746033 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2804 |
| topics[0].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[0].display_name | Neuropeptides and Animal Physiology |
| topics[1].id | https://openalex.org/T11651 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9966999888420105 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Inhalation and Respiratory Drug Delivery |
| topics[2].id | https://openalex.org/T11103 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9958999752998352 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2404 |
| topics[2].subfield.display_name | Microbiology |
| topics[2].display_name | Antimicrobial Peptides and Activities |
| funders[0].id | https://openalex.org/F4320306230 |
| funders[0].ror | https://ror.org/013kjyp64 |
| funders[0].display_name | American Heart Association |
| is_xpac | False |
| apc_list.value | 4100 |
| apc_list.currency | USD |
| apc_list.value_usd | 4100 |
| apc_paid.value | 4100 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 4100 |
| concepts[0].id | https://openalex.org/C2777961210 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7587566375732422 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q927148 |
| concepts[0].display_name | Bronchoalveolar lavage |
| concepts[1].id | https://openalex.org/C2777714996 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6833505630493164 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7886 |
| concepts[1].display_name | Lung |
| concepts[2].id | https://openalex.org/C2776914184 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6706328988075256 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[2].display_name | Inflammation |
| concepts[3].id | https://openalex.org/C207001950 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6328214406967163 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q141124 |
| concepts[3].display_name | In vivo |
| concepts[4].id | https://openalex.org/C98274493 |
| concepts[4].level | 1 |
| concepts[4].score | 0.6241217255592346 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[4].display_name | Pharmacology |
| concepts[5].id | https://openalex.org/C185592680 |
| concepts[5].level | 0 |
| concepts[5].score | 0.4954410791397095 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[5].display_name | Chemistry |
| concepts[6].id | https://openalex.org/C202751555 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4532427191734314 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[6].display_name | In vitro |
| concepts[7].id | https://openalex.org/C71924100 |
| concepts[7].level | 0 |
| concepts[7].score | 0.3735751509666443 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[7].display_name | Medicine |
| concepts[8].id | https://openalex.org/C203014093 |
| concepts[8].level | 1 |
| concepts[8].score | 0.31599852442741394 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[8].display_name | Immunology |
| concepts[9].id | https://openalex.org/C86803240 |
| concepts[9].level | 0 |
| concepts[9].score | 0.24747130274772644 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[9].display_name | Biology |
| concepts[10].id | https://openalex.org/C126322002 |
| concepts[10].level | 1 |
| concepts[10].score | 0.1330488920211792 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[10].display_name | Internal medicine |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.12952548265457153 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| concepts[12].id | https://openalex.org/C150903083 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7108 |
| concepts[12].display_name | Biotechnology |
| keywords[0].id | https://openalex.org/keywords/bronchoalveolar-lavage |
| keywords[0].score | 0.7587566375732422 |
| keywords[0].display_name | Bronchoalveolar lavage |
| keywords[1].id | https://openalex.org/keywords/lung |
| keywords[1].score | 0.6833505630493164 |
| keywords[1].display_name | Lung |
| keywords[2].id | https://openalex.org/keywords/inflammation |
| keywords[2].score | 0.6706328988075256 |
| keywords[2].display_name | Inflammation |
| keywords[3].id | https://openalex.org/keywords/in-vivo |
| keywords[3].score | 0.6328214406967163 |
| keywords[3].display_name | In vivo |
| keywords[4].id | https://openalex.org/keywords/pharmacology |
| keywords[4].score | 0.6241217255592346 |
| keywords[4].display_name | Pharmacology |
| keywords[5].id | https://openalex.org/keywords/chemistry |
| keywords[5].score | 0.4954410791397095 |
| keywords[5].display_name | Chemistry |
| keywords[6].id | https://openalex.org/keywords/in-vitro |
| keywords[6].score | 0.4532427191734314 |
| keywords[6].display_name | In vitro |
| keywords[7].id | https://openalex.org/keywords/medicine |
| keywords[7].score | 0.3735751509666443 |
| keywords[7].display_name | Medicine |
| keywords[8].id | https://openalex.org/keywords/immunology |
| keywords[8].score | 0.31599852442741394 |
| keywords[8].display_name | Immunology |
| keywords[9].id | https://openalex.org/keywords/biology |
| keywords[9].score | 0.24747130274772644 |
| keywords[9].display_name | Biology |
| keywords[10].id | https://openalex.org/keywords/internal-medicine |
| keywords[10].score | 0.1330488920211792 |
| keywords[10].display_name | Internal medicine |
| keywords[11].id | https://openalex.org/keywords/biochemistry |
| keywords[11].score | 0.12952548265457153 |
| keywords[11].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1172/jci.insight.140750 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2764964142 |
| locations[0].source.issn | 2379-3708 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2379-3708 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | JCI Insight |
| locations[0].source.host_organization | https://openalex.org/P4310320279 |
| locations[0].source.host_organization_name | American Society for Clinical Investigation |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320279 |
| locations[0].source.host_organization_lineage_names | American Society for Clinical Investigation |
| locations[0].license | cc-by |
| locations[0].pdf_url | http://insight.jci.org/articles/view/140750/files/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | JCI Insight |
| locations[0].landing_page_url | https://doi.org/10.1172/jci.insight.140750 |
| locations[1].id | pmid:33830084 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | JCI insight |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33830084 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:8119180 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | JCI Insight |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8119180 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5010278702 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1058-2273 |
| authorships[0].author.display_name | Sarah W. Robison |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210121221 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I32389192 |
| authorships[0].affiliations[1].raw_affiliation_string | Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[0].institutions[0].id | https://openalex.org/I4210121221 |
| authorships[0].institutions[0].ror | https://ror.org/01wx55d31 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210121221 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Pulmonary and Allergy Associates |
| authorships[0].institutions[1].id | https://openalex.org/I32389192 |
| authorships[0].institutions[1].ror | https://ror.org/008s83205 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I32389192 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | University of Alabama at Birmingham |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Sarah W. Robison |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and, Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[1].author.id | https://openalex.org/A5059894046 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | JinDong Li |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210115616 |
| authorships[1].affiliations[0].raw_affiliation_string | Birmingham VA Medical Center, Birmingham, Alabama, USA. |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I4210121221 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I32389192 |
| authorships[1].affiliations[2].raw_affiliation_string | Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[1].institutions[0].id | https://openalex.org/I4210115616 |
| authorships[1].institutions[0].ror | https://ror.org/0242qs713 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1322918889, https://openalex.org/I2799886695, https://openalex.org/I4210115616, https://openalex.org/I4210131075 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Birmingham VA Medical Center |
| authorships[1].institutions[1].id | https://openalex.org/I4210121221 |
| authorships[1].institutions[1].ror | https://ror.org/01wx55d31 |
| authorships[1].institutions[1].type | facility |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210121221 |
| authorships[1].institutions[1].country_code | US |
| authorships[1].institutions[1].display_name | Pulmonary and Allergy Associates |
| authorships[1].institutions[2].id | https://openalex.org/I32389192 |
| authorships[1].institutions[2].ror | https://ror.org/008s83205 |
| authorships[1].institutions[2].type | education |
| authorships[1].institutions[2].lineage | https://openalex.org/I32389192 |
| authorships[1].institutions[2].country_code | US |
| authorships[1].institutions[2].display_name | University of Alabama at Birmingham |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | JinDong Li |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Birmingham VA Medical Center, Birmingham, Alabama, USA., Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and, Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[2].author.id | https://openalex.org/A5113107739 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Liliana Viera |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I32389192 |
| authorships[2].affiliations[0].raw_affiliation_string | Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I4210121221 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and |
| authorships[2].institutions[0].id | https://openalex.org/I4210121221 |
| authorships[2].institutions[0].ror | https://ror.org/01wx55d31 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210121221 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Pulmonary and Allergy Associates |
| authorships[2].institutions[1].id | https://openalex.org/I32389192 |
| authorships[2].institutions[1].ror | https://ror.org/008s83205 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I32389192 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | University of Alabama at Birmingham |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Liliana Viera |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and, Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[3].author.id | https://openalex.org/A5025975655 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-0884-2061 |
| authorships[3].author.display_name | Jonathan P. Blackburn |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I32389192 |
| authorships[3].affiliations[0].raw_affiliation_string | Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I4210121221 |
| authorships[3].affiliations[1].raw_affiliation_string | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and |
| authorships[3].institutions[0].id | https://openalex.org/I4210121221 |
| authorships[3].institutions[0].ror | https://ror.org/01wx55d31 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210121221 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Pulmonary and Allergy Associates |
| authorships[3].institutions[1].id | https://openalex.org/I32389192 |
| authorships[3].institutions[1].ror | https://ror.org/008s83205 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I32389192 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | University of Alabama at Birmingham |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jonathan P. Blackburn |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and, Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[4].author.id | https://openalex.org/A5021751784 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1526-4303 |
| authorships[4].author.display_name | Rakesh P. Patel |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210150520 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pathology, Division of Molecular and Cellular Pathology, and |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I32389192 |
| authorships[4].affiliations[1].raw_affiliation_string | Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I32389192 |
| authorships[4].affiliations[2].raw_affiliation_string | Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[4].institutions[0].id | https://openalex.org/I4210150520 |
| authorships[4].institutions[0].ror | https://ror.org/04jvb9y72 |
| authorships[4].institutions[0].type | company |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210150520 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Cellular Research (United States) |
| authorships[4].institutions[1].id | https://openalex.org/I32389192 |
| authorships[4].institutions[1].ror | https://ror.org/008s83205 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I32389192 |
| authorships[4].institutions[1].country_code | US |
| authorships[4].institutions[1].display_name | University of Alabama at Birmingham |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Rakesh P. Patel |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Department of Pathology, Division of Molecular and Cellular Pathology, and, Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[5].author.id | https://openalex.org/A5085339251 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-5303-8123 |
| authorships[5].author.display_name | J. Edwin Blalock |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2800138454 |
| authorships[5].affiliations[0].raw_affiliation_string | Gregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama, USA. |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I32389192 |
| authorships[5].affiliations[1].raw_affiliation_string | Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[5].affiliations[2].institution_ids | https://openalex.org/I4210121221 |
| authorships[5].affiliations[2].raw_affiliation_string | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and |
| authorships[5].affiliations[3].institution_ids | https://openalex.org/I32389192 |
| authorships[5].affiliations[3].raw_affiliation_string | Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[5].institutions[0].id | https://openalex.org/I2800138454 |
| authorships[5].institutions[0].ror | https://ror.org/00ax59295 |
| authorships[5].institutions[0].type | nonprofit |
| authorships[5].institutions[0].lineage | https://openalex.org/I2800138454 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Cystic Fibrosis Foundation |
| authorships[5].institutions[1].id | https://openalex.org/I4210121221 |
| authorships[5].institutions[1].ror | https://ror.org/01wx55d31 |
| authorships[5].institutions[1].type | facility |
| authorships[5].institutions[1].lineage | https://openalex.org/I4210121221 |
| authorships[5].institutions[1].country_code | US |
| authorships[5].institutions[1].display_name | Pulmonary and Allergy Associates |
| authorships[5].institutions[2].id | https://openalex.org/I32389192 |
| authorships[5].institutions[2].ror | https://ror.org/008s83205 |
| authorships[5].institutions[2].type | education |
| authorships[5].institutions[2].lineage | https://openalex.org/I32389192 |
| authorships[5].institutions[2].country_code | US |
| authorships[5].institutions[2].display_name | University of Alabama at Birmingham |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | J. Edwin Blalock |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and, Gregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama, USA., Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, USA., Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[6].author.id | https://openalex.org/A5035278948 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-1586-5632 |
| authorships[6].author.display_name | Amit Gaggar |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I2800138454 |
| authorships[6].affiliations[0].raw_affiliation_string | Gregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama, USA. |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I32389192 |
| authorships[6].affiliations[1].raw_affiliation_string | Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I32389192 |
| authorships[6].affiliations[2].raw_affiliation_string | Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[6].affiliations[3].institution_ids | https://openalex.org/I4210115616 |
| authorships[6].affiliations[3].raw_affiliation_string | Birmingham VA Medical Center, Birmingham, Alabama, USA. |
| authorships[6].affiliations[4].institution_ids | https://openalex.org/I4210121221 |
| authorships[6].affiliations[4].raw_affiliation_string | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and |
| authorships[6].institutions[0].id | https://openalex.org/I4210115616 |
| authorships[6].institutions[0].ror | https://ror.org/0242qs713 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I1322918889, https://openalex.org/I2799886695, https://openalex.org/I4210115616, https://openalex.org/I4210131075 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Birmingham VA Medical Center |
| authorships[6].institutions[1].id | https://openalex.org/I2800138454 |
| authorships[6].institutions[1].ror | https://ror.org/00ax59295 |
| authorships[6].institutions[1].type | nonprofit |
| authorships[6].institutions[1].lineage | https://openalex.org/I2800138454 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | Cystic Fibrosis Foundation |
| authorships[6].institutions[2].id | https://openalex.org/I4210121221 |
| authorships[6].institutions[2].ror | https://ror.org/01wx55d31 |
| authorships[6].institutions[2].type | facility |
| authorships[6].institutions[2].lineage | https://openalex.org/I4210121221 |
| authorships[6].institutions[2].country_code | US |
| authorships[6].institutions[2].display_name | Pulmonary and Allergy Associates |
| authorships[6].institutions[3].id | https://openalex.org/I32389192 |
| authorships[6].institutions[3].ror | https://ror.org/008s83205 |
| authorships[6].institutions[3].type | education |
| authorships[6].institutions[3].lineage | https://openalex.org/I32389192 |
| authorships[6].institutions[3].country_code | US |
| authorships[6].institutions[3].display_name | University of Alabama at Birmingham |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Amit Gaggar |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Birmingham VA Medical Center, Birmingham, Alabama, USA., Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and, Gregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama, USA., Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, USA., Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[7].author.id | https://openalex.org/A5035305169 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-2469-6933 |
| authorships[7].author.display_name | Xin Xu |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I32389192 |
| authorships[7].affiliations[0].raw_affiliation_string | Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I4210115616 |
| authorships[7].affiliations[1].raw_affiliation_string | Birmingham VA Medical Center, Birmingham, Alabama, USA. |
| authorships[7].affiliations[2].institution_ids | https://openalex.org/I4210121221 |
| authorships[7].affiliations[2].raw_affiliation_string | Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and |
| authorships[7].affiliations[3].institution_ids | https://openalex.org/I2800138454 |
| authorships[7].affiliations[3].raw_affiliation_string | Gregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama, USA. |
| authorships[7].affiliations[4].institution_ids | https://openalex.org/I32389192 |
| authorships[7].affiliations[4].raw_affiliation_string | Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| authorships[7].institutions[0].id | https://openalex.org/I4210115616 |
| authorships[7].institutions[0].ror | https://ror.org/0242qs713 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1322918889, https://openalex.org/I2799886695, https://openalex.org/I4210115616, https://openalex.org/I4210131075 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Birmingham VA Medical Center |
| authorships[7].institutions[1].id | https://openalex.org/I2800138454 |
| authorships[7].institutions[1].ror | https://ror.org/00ax59295 |
| authorships[7].institutions[1].type | nonprofit |
| authorships[7].institutions[1].lineage | https://openalex.org/I2800138454 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | Cystic Fibrosis Foundation |
| authorships[7].institutions[2].id | https://openalex.org/I4210121221 |
| authorships[7].institutions[2].ror | https://ror.org/01wx55d31 |
| authorships[7].institutions[2].type | facility |
| authorships[7].institutions[2].lineage | https://openalex.org/I4210121221 |
| authorships[7].institutions[2].country_code | US |
| authorships[7].institutions[2].display_name | Pulmonary and Allergy Associates |
| authorships[7].institutions[3].id | https://openalex.org/I32389192 |
| authorships[7].institutions[3].ror | https://ror.org/008s83205 |
| authorships[7].institutions[3].type | education |
| authorships[7].institutions[3].lineage | https://openalex.org/I32389192 |
| authorships[7].institutions[3].country_code | US |
| authorships[7].institutions[3].display_name | University of Alabama at Birmingham |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Xin Xu |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Birmingham VA Medical Center, Birmingham, Alabama, USA., Department of Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, and, Gregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama, USA., Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, USA., Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://insight.jci.org/articles/view/140750/files/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A mechanism for matrikine regulation in acute inflammatory lung injury |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10814 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.9990000128746033 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2804 |
| primary_topic.subfield.display_name | Cellular and Molecular Neuroscience |
| primary_topic.display_name | Neuropeptides and Animal Physiology |
| related_works | https://openalex.org/W2138350991, https://openalex.org/W1566729005, https://openalex.org/W2409285845, https://openalex.org/W2434195791, https://openalex.org/W1994342570, https://openalex.org/W2562771455, https://openalex.org/W2054843986, https://openalex.org/W2440701365, https://openalex.org/W2433842723, https://openalex.org/W2375002500 |
| cited_by_count | 11 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 4 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1172/jci.insight.140750 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764964142 |
| best_oa_location.source.issn | 2379-3708 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2379-3708 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | JCI Insight |
| best_oa_location.source.host_organization | https://openalex.org/P4310320279 |
| best_oa_location.source.host_organization_name | American Society for Clinical Investigation |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320279 |
| best_oa_location.source.host_organization_lineage_names | American Society for Clinical Investigation |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | http://insight.jci.org/articles/view/140750/files/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | JCI Insight |
| best_oa_location.landing_page_url | https://doi.org/10.1172/jci.insight.140750 |
| primary_location.id | doi:10.1172/jci.insight.140750 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2764964142 |
| primary_location.source.issn | 2379-3708 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2379-3708 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | JCI Insight |
| primary_location.source.host_organization | https://openalex.org/P4310320279 |
| primary_location.source.host_organization_name | American Society for Clinical Investigation |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320279 |
| primary_location.source.host_organization_lineage_names | American Society for Clinical Investigation |
| primary_location.license | cc-by |
| primary_location.pdf_url | http://insight.jci.org/articles/view/140750/files/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | JCI Insight |
| primary_location.landing_page_url | https://doi.org/10.1172/jci.insight.140750 |
| publication_date | 2021-04-07 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W4294658238, https://openalex.org/W2068854215, https://openalex.org/W2047406342, https://openalex.org/W2106923828, https://openalex.org/W2597070792, https://openalex.org/W2110874917, https://openalex.org/W2108329413, https://openalex.org/W2159763561, https://openalex.org/W2065328100, https://openalex.org/W2035683946, https://openalex.org/W2516333179, https://openalex.org/W2166562100, https://openalex.org/W2106974683, https://openalex.org/W1910308666, https://openalex.org/W2888526997, https://openalex.org/W2119969852, https://openalex.org/W2810603746, https://openalex.org/W1983911319, https://openalex.org/W2769031443, https://openalex.org/W2887500589, https://openalex.org/W1985175990, https://openalex.org/W2037198044, https://openalex.org/W2003572328, https://openalex.org/W1731317824, https://openalex.org/W2127926069, https://openalex.org/W931335789, https://openalex.org/W2018361792, https://openalex.org/W1480582936, https://openalex.org/W2169876454, https://openalex.org/W2060481103, https://openalex.org/W1884454078, https://openalex.org/W2114534996, https://openalex.org/W2099023080, https://openalex.org/W2747516285, https://openalex.org/W1988480204, https://openalex.org/W2073800036, https://openalex.org/W2168504180, https://openalex.org/W3013334176, https://openalex.org/W3013816672, https://openalex.org/W3026716332, https://openalex.org/W6776451210, https://openalex.org/W3025129816, https://openalex.org/W1803784511, https://openalex.org/W3021823248, https://openalex.org/W2093852073 |
| referenced_works_count | 45 |
| abstract_inverted_index.a | 21, 64, 69, 103, 191, 205 |
| abstract_inverted_index.In | 90 |
| abstract_inverted_index.We | 150 |
| abstract_inverted_index.an | 132 |
| abstract_inverted_index.as | 190, 204 |
| abstract_inverted_index.by | 11, 53 |
| abstract_inverted_index.in | 23, 33, 63, 72, 78, 97, 126, 164, 180, 183 |
| abstract_inverted_index.is | 170 |
| abstract_inverted_index.it | 201 |
| abstract_inverted_index.of | 61, 74, 93, 102, 106, 112, 124, 186, 193 |
| abstract_inverted_index.or | 100 |
| abstract_inverted_index.to | 19, 87, 174, 177, 198 |
| abstract_inverted_index.we | 42, 138 |
| abstract_inverted_index.BAL | 127 |
| abstract_inverted_index.and | 2, 14, 85, 128, 147, 182, 197 |
| abstract_inverted_index.are | 7, 47 |
| abstract_inverted_index.for | 30 |
| abstract_inverted_index.had | 121 |
| abstract_inverted_index.has | 36 |
| abstract_inverted_index.its | 3 |
| abstract_inverted_index.may | 202 |
| abstract_inverted_index.not | 37 |
| abstract_inverted_index.our | 175 |
| abstract_inverted_index.the | 28, 51, 54, 75, 79, 94, 171, 179 |
| abstract_inverted_index.use | 101 |
| abstract_inverted_index.was | 68 |
| abstract_inverted_index.This | 169 |
| abstract_inverted_index.been | 17, 38 |
| abstract_inverted_index.form | 5 |
| abstract_inverted_index.from | 50, 158 |
| abstract_inverted_index.have | 16 |
| abstract_inverted_index.lung | 52, 129, 135, 148, 162 |
| abstract_inverted_index.over | 83 |
| abstract_inverted_index.play | 20 |
| abstract_inverted_index.plus | 119 |
| abstract_inverted_index.role | 22 |
| abstract_inverted_index.show | 43 |
| abstract_inverted_index.that | 44, 115, 140, 200 |
| abstract_inverted_index.they | 15 |
| abstract_inverted_index.this | 153 |
| abstract_inverted_index.time | 84 |
| abstract_inverted_index.vivo | 184 |
| abstract_inverted_index.well | 39 |
| abstract_inverted_index.with | 160, 166 |
| abstract_inverted_index.(BAL) | 82 |
| abstract_inverted_index.(PGP) | 1 |
| abstract_inverted_index.Here, | 41 |
| abstract_inverted_index.PEPT2 | 95, 141 |
| abstract_inverted_index.acute | 34, 133, 161, 195 |
| abstract_inverted_index.first | 172 |
| abstract_inverted_index.mouse | 65 |
| abstract_inverted_index.rapid | 70 |
| abstract_inverted_index.serve | 203 |
| abstract_inverted_index.shown | 18 |
| abstract_inverted_index.study | 173 |
| abstract_inverted_index.there | 67 |
| abstract_inverted_index.these | 45 |
| abstract_inverted_index.using | 155 |
| abstract_inverted_index.vitro | 91, 181 |
| abstract_inverted_index.Ac-PGP | 62, 118, 125, 145 |
| abstract_inverted_index.PEPT2, | 107 |
| abstract_inverted_index.PEPT2. | 57 |
| abstract_inverted_index.active | 187 |
| abstract_inverted_index.airway | 98, 167 |
| abstract_inverted_index.effect | 154 |
| abstract_inverted_index.higher | 122 |
| abstract_inverted_index.injury | 136, 163 |
| abstract_inverted_index.lavage | 81 |
| abstract_inverted_index.levels | 123, 146 |
| abstract_inverted_index.model, | 66, 137 |
| abstract_inverted_index.sites. | 89 |
| abstract_inverted_index.uptake | 111 |
| abstract_inverted_index.Ac-PGP. | 113 |
| abstract_inverted_index.Animals | 114 |
| abstract_inverted_index.chronic | 24 |
| abstract_inverted_index.decline | 71 |
| abstract_inverted_index.further | 151 |
| abstract_inverted_index.labeled | 76 |
| abstract_inverted_index.peptide | 77 |
| abstract_inverted_index.reduced | 110 |
| abstract_inverted_index.samples | 157 |
| abstract_inverted_index.target. | 208 |
| abstract_inverted_index.tissue. | 130 |
| abstract_inverted_index.(Ac-PGP) | 6 |
| abstract_inverted_index.However, | 27 |
| abstract_inverted_index.actively | 48 |
| abstract_inverted_index.blockade | 142 |
| abstract_inverted_index.clinical | 156 |
| abstract_inverted_index.collagen | 12 |
| abstract_inverted_index.disease. | 26 |
| abstract_inverted_index.enhanced | 143 |
| abstract_inverted_index.patients | 159 |
| abstract_inverted_index.peptides | 46 |
| abstract_inverted_index.received | 116 |
| abstract_inverted_index.Following | 58 |
| abstract_inverted_index.Utilizing | 131 |
| abstract_inverted_index.coculture | 165 |
| abstract_inverted_index.determine | 178 |
| abstract_inverted_index.epithelia | 99 |
| abstract_inverted_index.generated | 10 |
| abstract_inverted_index.inhibitor | 105 |
| abstract_inverted_index.knockdown | 92 |
| abstract_inverted_index.knowledge | 176 |
| abstract_inverted_index.matrikine | 31, 188 |
| abstract_inverted_index.mechanism | 29, 192 |
| abstract_inverted_index.potential | 206 |
| abstract_inverted_index.pulmonary | 144 |
| abstract_inverted_index.transport | 189 |
| abstract_inverted_index.validated | 152 |
| abstract_inverted_index.acetylated | 4 |
| abstract_inverted_index.cefadroxil | 120 |
| abstract_inverted_index.epithelia. | 168 |
| abstract_inverted_index.modulating | 194 |
| abstract_inverted_index.neutrophil | 8 |
| abstract_inverted_index.regulation | 32 |
| abstract_inverted_index.LPS-induced | 134 |
| abstract_inverted_index.cefadroxil, | 108 |
| abstract_inverted_index.competitive | 104 |
| abstract_inverted_index.demonstrate | 139, 199 |
| abstract_inverted_index.therapeutic | 207 |
| abstract_inverted_index.transported | 49 |
| abstract_inverted_index.transporter | 96 |
| abstract_inverted_index.degradation, | 13 |
| abstract_inverted_index.established. | 40 |
| abstract_inverted_index.inflammation | 35, 196 |
| abstract_inverted_index.inflammatory | 25 |
| abstract_inverted_index.instillation | 60 |
| abstract_inverted_index.oligopeptide | 55 |
| abstract_inverted_index.significance | 185 |
| abstract_inverted_index.transporter, | 56 |
| abstract_inverted_index.concentration | 73 |
| abstract_inverted_index.inflammation. | 149 |
| abstract_inverted_index.intratracheal | 59, 117 |
| abstract_inverted_index.significantly | 109 |
| abstract_inverted_index.extrapulmonary | 88 |
| abstract_inverted_index.redistribution | 86 |
| abstract_inverted_index.bronchoalveolar | 80 |
| abstract_inverted_index.chemoattractants | 9 |
| abstract_inverted_index.Proline-glycine-proline | 0 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5035278948 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I2800138454, https://openalex.org/I32389192, https://openalex.org/I4210115616, https://openalex.org/I4210121221 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.71382464 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |