A meta-analysis of the effects of proton pump inhibitors on the risk of gastric cancer Article Swipe
Hao Zhang
,
Xianyu Meng
,
Dongyun Gou
,
Xiaojing Liu
,
Yu Huang
,
Siyu Liu
,
Haiyang Wang
,
Hongyan Li
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1097/md.0000000000043053
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1097/md.0000000000043053
Background: Proton pump inhibitors (PPIs) are commonly prescribed drugs in clinical practice, mainly for the treatment of Helicobacter pylori infection and gastroesophageal reflux disease (GERD). With the application of PPIs, doctors have found a variety of adverse reactions related to it, with gastric cancer being the most serious. Our aim is to investigate whether the use of PPIs increases the probability of gastric cancer. Methods: By searching PubMed, EMBASE, the Cochrane Library and Web of science, references related to PPIs and gastric cancer were selected, and Newcastle-Ottawa scale (NOS) was used to evaluate the quality of the included references and analyze their bias. Then stataSE-64 was used for statistical analysis. The above processes were independently searched and evaluated by 2 researchers. Results: The use of PPIs significantly increased the incidence of gastric cancer (RR = 1.75, 95% CI: 1.48–2.07, P = .000). Conclusion: Long-term use of PPIs may increase the incidence of gastric cancer.
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Metadata
- Type
- review
- Language
- en
- Landing Page
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- OA Status
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- References
- 38
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412403393Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/md.0000000000043053Digital Object Identifier
- Title
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A meta-analysis of the effects of proton pump inhibitors on the risk of gastric cancerWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-11Full publication date if available
- Authors
-
Hao Zhang, Xianyu Meng, Dongyun Gou, Xiaojing Liu, Yu Huang, Siyu Liu, Haiyang Wang, Hongyan LiList of authors in order
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https://doi.org/10.1097/md.0000000000043053Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1097/md.0000000000043053Direct OA link when available
- Concepts
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Medicine, Helicobacter pylori, Cochrane Library, Cancer, Internal medicine, Incidence (geometry), GERD, Proton-pump inhibitor, Gastroenterology, Meta-analysis, Disease, Oncology, Reflux, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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38Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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