A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasite Article Swipe
Sebastian Baumgarten
,
Justine Couble
,
Tiziano Vignolini
,
Gregory J. Dore
,
Bérangère Lombard
,
Damarys Loew
,
Michael J. Richard
,
Michael Buettner
,
Gernot Poschet
,
R Sánchez
,
Jessica M. Bryant
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.03.22.644534
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.03.22.644534
The transmission of the most virulent human malaria parasite, Plasmodium falciparum , relies on its survival in the contrasting environments of the human host and mosquito vector. One of the most fascinating adaptations to this lifestyle is the specific silencing of individual rDNA genes in the human host that are de-repressed following host-to-vector transmission. In this study, we defined the epigenetic signatures of rRNA transcription and found that rDNA silencing relies on aerobic glycolysis, the sole energy-generating pathway in the human host. We show that disruption of NAD + regeneration during lactate fermentation promotes rDNA de-repression and identify the sirtuin histone deacetylase Sir2a as the mediator between fluctuating NAD + levels and a functional transcriptional outcome. Hence, rDNA activation appears to be coupled to the metabolic state of the parasite as it transitions from aerobic glycolysis to mitochondrial respiration during host-to-vector transmission.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.03.22.644534
- https://www.biorxiv.org/content/biorxiv/early/2025/03/22/2025.03.22.644534.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 88
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408767472
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408767472Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.03.22.644534Digital Object Identifier
- Title
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A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasiteWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-22Full publication date if available
- Authors
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Sebastian Baumgarten, Justine Couble, Tiziano Vignolini, Gregory J. Dore, Bérangère Lombard, Damarys Loew, Michael J. Richard, Michael Buettner, Gernot Poschet, R Sánchez, Jessica M. BryantList of authors in order
- Landing page
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https://doi.org/10.1101/2025.03.22.644534Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2025/03/22/2025.03.22.644534.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/03/22/2025.03.22.644534.full.pdfDirect OA link when available
- Concepts
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Malaria, Parasite hosting, Chromatin, Biology, Ribosome, Cell biology, Genetics, Immunology, Computer science, RNA, DNA, Gene, World Wide WebTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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88Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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