A Method To Prevent SARS-CoV-2 IgM False Positives in Gold Immunochromatography and Enzyme-Linked Immunosorbent Assays Article Swipe

View

Related Concepts

Mycoplasma pneumoniae Virology Medicine Immunoglobulin M Virus Antibody Immunology Coronavirus Pneumonia Microbiology Immunoglobulin G Biology Coronavirus disease 2019 (COVID-19) Disease Infectious disease (medical specialty) Internal medicine

Qiang Wang , Qin Du , Bin Guo , Daiyong Mu , Xiaolan Lu , Qiang Ma , Yangliu Guo , Fang Li , Bing Zhang , Guoyuan Zhang , Xiaolan Guo ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.1128/jcm.00375-20 · OA: W3016165935

We set out to investigate the interference factors that led to false-positive novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgM detection results using gold immunochromatography assay (GICA) and enzyme-linked immunosorbent assay (ELISA) and the corresponding solutions. GICA and ELISA were used to detect SARS-CoV-2 IgM in 86 serum samples, including 5 influenza A virus (Flu A) IgM-positive sera, 5 influenza B virus (Flu B) IgM-positive sera, 5 Mycoplasma pneumoniae IgM-positive sera, 5 Legionella pneumophila IgM-positive sera, 6 sera of HIV infection patients, 36 rheumatoid factor IgM (RF-IgM)-positive sera, 5 sera from hypertensive patients, 5 sera from diabetes mellitus patients, and 14 sera from novel coronavirus infection disease 19 (COVID-19) patients.