A microRNA-mRNA regulatory network explains the landscape of the de novo cytogenetically normal acute myeloid leukaemia Article Swipe
Ezalia Esa
,
Ariwibawa Kasmani Hashim
,
Zubaidah Zakaria
,
Alifah Nadia Abu Hassan
,
Yuslina Mat Yusoff
,
Nor Rizan Kamaluddin
,
Ahmad Zuhairi Abdul Rahman
,
Elsa Haniffah Mejia Mohamed
,
Kian Meng Chang
,
Rashidah Mohamed
,
Indhira Subbiah
,
Ehram Jamian
,
Caroline Siew Ling Ho
,
Soo Min Lim
,
Peng Choon Lau
,
Yuh Fen Pung
,
Shamsul Mohd Zain
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.10250945
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.10250945
The association between dysregulated microRNAs (miRNAs) and cytogenetically normal acute myeloid leukaemia (CN-AML) is well reported. However, our understanding on the regulatory role of miRNAs in CN-AML pathway is still poor. The current study integrated both miRNA and mRNA profiles to explore novel miRNA-mRNA interactions that affect the regulatory patterns in de novo CN-AML. Twenty-four (24) newly diagnosed CN-AML patients were matched on age, gender and ethnicity to the controls with a 1:1 ratio. Blood samples collected from patients were used to extract total RNA. The total RNA is used to quantify miRNA and mRNA profiles using the multiplexed nCounter platform. Significant miRNA and mRNA expressions were identified using the following criteria; P-value <0.05 with fold change more than 1.5 or less than 1.5 (FC>1.5 or FC A correlation matrix was set up to correlate miRNA and mRNA data. We were only interested in negative correlation as miRNA plays inhibitory role towards mRNA. Correlation deemed meaningful at r
Related Topics
Concepts
Metadata
- Type
- dataset
- Language
- en
- Landing Page
- https://doi.org/10.6084/m9.figshare.10250945
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394104284
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4394104284Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.6084/m9.figshare.10250945Digital Object Identifier
- Title
-
A microRNA-mRNA regulatory network explains the landscape of the de novo cytogenetically normal acute myeloid leukaemiaWork title
- Type
-
datasetOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-01-01Full publication date if available
- Authors
-
Ezalia Esa, Ariwibawa Kasmani Hashim, Zubaidah Zakaria, Alifah Nadia Abu Hassan, Yuslina Mat Yusoff, Nor Rizan Kamaluddin, Ahmad Zuhairi Abdul Rahman, Elsa Haniffah Mejia Mohamed, Kian Meng Chang, Rashidah Mohamed, Indhira Subbiah, Ehram Jamian, Caroline Siew Ling Ho, Soo Min Lim, Peng Choon Lau, Yuh Fen Pung, Shamsul Mohd ZainList of authors in order
- Landing page
-
https://doi.org/10.6084/m9.figshare.10250945Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.6084/m9.figshare.10250945Direct OA link when available
- Concepts
-
Myeloid leukaemia, microRNA, Biology, Myeloid, Computational biology, Messenger RNA, Gene, Genetics, Immunology, Cancer researchTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4394104284 |
|---|---|
| doi | https://doi.org/10.6084/m9.figshare.10250945 |
| ids.doi | https://doi.org/10.6084/m9.figshare.10250945 |
| ids.openalex | https://openalex.org/W4394104284 |
| fwci | |
| type | dataset |
| title | A microRNA-mRNA regulatory network explains the landscape of the de novo cytogenetically normal acute myeloid leukaemia |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10062 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9610000252723694 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1306 |
| topics[0].subfield.display_name | Cancer Research |
| topics[0].display_name | MicroRNA in disease regulation |
| topics[1].id | https://openalex.org/T10604 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9092000126838684 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | RNA Research and Splicing |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2993296363 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8119598627090454 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11688946 |
| concepts[0].display_name | Myeloid leukaemia |
| concepts[1].id | https://openalex.org/C145059251 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7642437219619751 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q310899 |
| concepts[1].display_name | microRNA |
| concepts[2].id | https://openalex.org/C86803240 |
| concepts[2].level | 0 |
| concepts[2].score | 0.5376817584037781 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[2].display_name | Biology |
| concepts[3].id | https://openalex.org/C2779282312 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5173786878585815 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1956561 |
| concepts[3].display_name | Myeloid |
| concepts[4].id | https://openalex.org/C70721500 |
| concepts[4].level | 1 |
| concepts[4].score | 0.4788393974304199 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[4].display_name | Computational biology |
| concepts[5].id | https://openalex.org/C105580179 |
| concepts[5].level | 3 |
| concepts[5].score | 0.46282583475112915 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q188928 |
| concepts[5].display_name | Messenger RNA |
| concepts[6].id | https://openalex.org/C104317684 |
| concepts[6].level | 2 |
| concepts[6].score | 0.3989325165748596 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[6].display_name | Gene |
| concepts[7].id | https://openalex.org/C54355233 |
| concepts[7].level | 1 |
| concepts[7].score | 0.397037148475647 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[7].display_name | Genetics |
| concepts[8].id | https://openalex.org/C203014093 |
| concepts[8].level | 1 |
| concepts[8].score | 0.32629114389419556 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[8].display_name | Immunology |
| concepts[9].id | https://openalex.org/C502942594 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3235524892807007 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[9].display_name | Cancer research |
| keywords[0].id | https://openalex.org/keywords/myeloid-leukaemia |
| keywords[0].score | 0.8119598627090454 |
| keywords[0].display_name | Myeloid leukaemia |
| keywords[1].id | https://openalex.org/keywords/microrna |
| keywords[1].score | 0.7642437219619751 |
| keywords[1].display_name | microRNA |
| keywords[2].id | https://openalex.org/keywords/biology |
| keywords[2].score | 0.5376817584037781 |
| keywords[2].display_name | Biology |
| keywords[3].id | https://openalex.org/keywords/myeloid |
| keywords[3].score | 0.5173786878585815 |
| keywords[3].display_name | Myeloid |
| keywords[4].id | https://openalex.org/keywords/computational-biology |
| keywords[4].score | 0.4788393974304199 |
| keywords[4].display_name | Computational biology |
| keywords[5].id | https://openalex.org/keywords/messenger-rna |
| keywords[5].score | 0.46282583475112915 |
| keywords[5].display_name | Messenger RNA |
| keywords[6].id | https://openalex.org/keywords/gene |
| keywords[6].score | 0.3989325165748596 |
| keywords[6].display_name | Gene |
| keywords[7].id | https://openalex.org/keywords/genetics |
| keywords[7].score | 0.397037148475647 |
| keywords[7].display_name | Genetics |
| keywords[8].id | https://openalex.org/keywords/immunology |
| keywords[8].score | 0.32629114389419556 |
| keywords[8].display_name | Immunology |
| keywords[9].id | https://openalex.org/keywords/cancer-research |
| keywords[9].score | 0.3235524892807007 |
| keywords[9].display_name | Cancer research |
| language | en |
| locations[0].id | doi:10.6084/m9.figshare.10250945 |
| locations[0].is_oa | True |
| locations[0].source | |
| locations[0].license | public-domain |
| locations[0].pdf_url | |
| locations[0].version | |
| locations[0].raw_type | dataset |
| locations[0].license_id | https://openalex.org/licenses/public-domain |
| locations[0].is_accepted | False |
| locations[0].is_published | |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.6084/m9.figshare.10250945 |
| indexed_in | datacite |
| authorships[0].author.id | https://openalex.org/A5042758278 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-8699-1017 |
| authorships[0].author.display_name | Ezalia Esa |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ezalia Esa |
| authorships[0].is_corresponding | False |
| authorships[1].author.id | https://openalex.org/A5051871408 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Ariwibawa Kasmani Hashim |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ariwibawa Kasmani Hashim |
| authorships[1].is_corresponding | False |
| authorships[2].author.id | https://openalex.org/A5103892098 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Zubaidah Zakaria |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Zubaidah Zakaria |
| authorships[2].is_corresponding | False |
| authorships[3].author.id | https://openalex.org/A5112618009 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Alifah Nadia Abu Hassan |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Alifah Nadia Abu Hassan |
| authorships[3].is_corresponding | False |
| authorships[4].author.id | https://openalex.org/A5049344077 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Yuslina Mat Yusoff |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Yuslina Mat Yusoff |
| authorships[4].is_corresponding | False |
| authorships[5].author.id | https://openalex.org/A5051905435 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Nor Rizan Kamaluddin |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Nor Rizan Kamaluddin |
| authorships[5].is_corresponding | False |
| authorships[6].author.id | https://openalex.org/A5080869424 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Ahmad Zuhairi Abdul Rahman |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ahmad Zuhairi Abdul Rahman |
| authorships[6].is_corresponding | False |
| authorships[7].author.id | https://openalex.org/A5086112965 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-5091-2970 |
| authorships[7].author.display_name | Elsa Haniffah Mejia Mohamed |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Elsa Haniffah Mejia Mohamed |
| authorships[7].is_corresponding | False |
| authorships[8].author.id | https://openalex.org/A5011013003 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-0804-9389 |
| authorships[8].author.display_name | Kian Meng Chang |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Kian Meng Chang |
| authorships[8].is_corresponding | False |
| authorships[9].author.id | https://openalex.org/A5082449886 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Rashidah Mohamed |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Rashidah Mohamed |
| authorships[9].is_corresponding | False |
| authorships[10].author.id | https://openalex.org/A5057986077 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Indhira Subbiah |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Indhira Subbiah |
| authorships[10].is_corresponding | False |
| authorships[11].author.id | https://openalex.org/A5008237072 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Ehram Jamian |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Ehram Jamian |
| authorships[11].is_corresponding | False |
| authorships[12].author.id | https://openalex.org/A5102641989 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Caroline Siew Ling Ho |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Caroline Siew Ling Ho |
| authorships[12].is_corresponding | False |
| authorships[13].author.id | https://openalex.org/A5101056152 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | Soo Min Lim |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Soo Min Lim |
| authorships[13].is_corresponding | False |
| authorships[14].author.id | https://openalex.org/A5111164393 |
| authorships[14].author.orcid | |
| authorships[14].author.display_name | Peng Choon Lau |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Peng Choon Lau |
| authorships[14].is_corresponding | False |
| authorships[15].author.id | https://openalex.org/A5037543602 |
| authorships[15].author.orcid | https://orcid.org/0000-0001-6195-3970 |
| authorships[15].author.display_name | Yuh Fen Pung |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Yuh Fen Pung |
| authorships[15].is_corresponding | False |
| authorships[16].author.id | https://openalex.org/A5060860250 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-3441-6659 |
| authorships[16].author.display_name | Shamsul Mohd Zain |
| authorships[16].author_position | last |
| authorships[16].raw_author_name | Shamsul Mohd Zain |
| authorships[16].is_corresponding | False |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.6084/m9.figshare.10250945 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A microRNA-mRNA regulatory network explains the landscape of the de novo cytogenetically normal acute myeloid leukaemia |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T06:51:31.235846 |
| primary_topic.id | https://openalex.org/T10062 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9610000252723694 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1306 |
| primary_topic.subfield.display_name | Cancer Research |
| primary_topic.display_name | MicroRNA in disease regulation |
| related_works | https://openalex.org/W4214866116, https://openalex.org/W2737319532, https://openalex.org/W4392896533, https://openalex.org/W2062945643, https://openalex.org/W2050308539, https://openalex.org/W3151405604, https://openalex.org/W1502047676, https://openalex.org/W2565797512, https://openalex.org/W2800200469, https://openalex.org/W2407467520 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.6084/m9.figshare.10250945 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | public-domain |
| best_oa_location.pdf_url | |
| best_oa_location.version | |
| best_oa_location.raw_type | dataset |
| best_oa_location.license_id | https://openalex.org/licenses/public-domain |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.6084/m9.figshare.10250945 |
| primary_location.id | doi:10.6084/m9.figshare.10250945 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | public-domain |
| primary_location.pdf_url | |
| primary_location.version | |
| primary_location.raw_type | dataset |
| primary_location.license_id | https://openalex.org/licenses/public-domain |
| primary_location.is_accepted | False |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.6084/m9.figshare.10250945 |
| publication_date | 2019-01-01 |
| publication_year | 2019 |
| referenced_works_count | 0 |
| abstract_inverted_index.A | 127 |
| abstract_inverted_index.a | 71 |
| abstract_inverted_index.FC | 126 |
| abstract_inverted_index.We | 139 |
| abstract_inverted_index.as | 146 |
| abstract_inverted_index.at | 156 |
| abstract_inverted_index.in | 25, 50, 143 |
| abstract_inverted_index.is | 13, 28, 88 |
| abstract_inverted_index.of | 23 |
| abstract_inverted_index.on | 19, 62 |
| abstract_inverted_index.or | 120, 125 |
| abstract_inverted_index.to | 40, 67, 81, 90, 133 |
| abstract_inverted_index.up | 132 |
| abstract_inverted_index.1.5 | 119, 123 |
| abstract_inverted_index.1:1 | 72 |
| abstract_inverted_index.RNA | 87 |
| abstract_inverted_index.The | 0, 31, 85 |
| abstract_inverted_index.and | 6, 37, 65, 93, 103, 136 |
| abstract_inverted_index.our | 17 |
| abstract_inverted_index.set | 131 |
| abstract_inverted_index.the | 20, 47, 68, 97, 109 |
| abstract_inverted_index.was | 130 |
| abstract_inverted_index.(24) | 55 |
| abstract_inverted_index.RNA. | 84 |
| abstract_inverted_index.age, | 63 |
| abstract_inverted_index.both | 35 |
| abstract_inverted_index.fold | 115 |
| abstract_inverted_index.from | 77 |
| abstract_inverted_index.less | 121 |
| abstract_inverted_index.mRNA | 38, 94, 104, 137 |
| abstract_inverted_index.more | 117 |
| abstract_inverted_index.only | 141 |
| abstract_inverted_index.role | 22, 150 |
| abstract_inverted_index.than | 118, 122 |
| abstract_inverted_index.that | 45 |
| abstract_inverted_index.used | 80, 89 |
| abstract_inverted_index.well | 14 |
| abstract_inverted_index.were | 60, 79, 106, 140 |
| abstract_inverted_index.with | 70, 114 |
| abstract_inverted_index.<i>de | 51 |
| abstract_inverted_index.Blood | 74 |
| abstract_inverted_index.acute | 9 |
| abstract_inverted_index.data. | 138 |
| abstract_inverted_index.mRNA. | 152 |
| abstract_inverted_index.miRNA | 36, 92, 102, 135, 147 |
| abstract_inverted_index.newly | 56 |
| abstract_inverted_index.novel | 42 |
| abstract_inverted_index.plays | 148 |
| abstract_inverted_index.poor. | 30 |
| abstract_inverted_index.r<br> | 157 |
| abstract_inverted_index.still | 29 |
| abstract_inverted_index.study | 33 |
| abstract_inverted_index.total | 83, 86 |
| abstract_inverted_index.using | 96, 108 |
| abstract_inverted_index.CN-AML | 26, 58 |
| abstract_inverted_index.affect | 46 |
| abstract_inverted_index.change | 116 |
| abstract_inverted_index.deemed | 154 |
| abstract_inverted_index.gender | 64 |
| abstract_inverted_index.matrix | 129 |
| abstract_inverted_index.miRNAs | 24 |
| abstract_inverted_index.normal | 8 |
| abstract_inverted_index.ratio. | 73 |
| abstract_inverted_index.CN-AML. | 53 |
| abstract_inverted_index.P-value | 112 |
| abstract_inverted_index.between | 2 |
| abstract_inverted_index.current | 32 |
| abstract_inverted_index.explore | 41 |
| abstract_inverted_index.extract | 82 |
| abstract_inverted_index.matched | 61 |
| abstract_inverted_index.myeloid | 10 |
| abstract_inverted_index.pathway | 27 |
| abstract_inverted_index.samples | 75 |
| abstract_inverted_index.towards | 151 |
| abstract_inverted_index.<0.05 | 113 |
| abstract_inverted_index.(CN-AML) | 12 |
| abstract_inverted_index.(miRNAs) | 5 |
| abstract_inverted_index.However, | 16 |
| abstract_inverted_index.controls | 69 |
| abstract_inverted_index.nCounter | 99 |
| abstract_inverted_index.negative | 144 |
| abstract_inverted_index.novo</i> | 52 |
| abstract_inverted_index.patients | 59, 78 |
| abstract_inverted_index.patterns | 49 |
| abstract_inverted_index.profiles | 39, 95 |
| abstract_inverted_index.quantify | 91 |
| abstract_inverted_index.collected | 76 |
| abstract_inverted_index.correlate | 134 |
| abstract_inverted_index.criteria; | 111 |
| abstract_inverted_index.diagnosed | 57 |
| abstract_inverted_index.ethnicity | 66 |
| abstract_inverted_index.following | 110 |
| abstract_inverted_index.leukaemia | 11 |
| abstract_inverted_index.microRNAs | 4 |
| abstract_inverted_index.platform. | 100 |
| abstract_inverted_index.reported. | 15 |
| abstract_inverted_index.(FC>1.5 | 124 |
| abstract_inverted_index.identified | 107 |
| abstract_inverted_index.inhibitory | 149 |
| abstract_inverted_index.integrated | 34 |
| abstract_inverted_index.interested | 142 |
| abstract_inverted_index.meaningful | 155 |
| abstract_inverted_index.miRNA-mRNA | 43 |
| abstract_inverted_index.regulatory | 21, 48 |
| abstract_inverted_index.Correlation | 153 |
| abstract_inverted_index.Significant | 101 |
| abstract_inverted_index.Twenty-four | 54 |
| abstract_inverted_index.association | 1 |
| abstract_inverted_index.correlation | 128, 145 |
| abstract_inverted_index.expressions | 105 |
| abstract_inverted_index.multiplexed | 98 |
| abstract_inverted_index.dysregulated | 3 |
| abstract_inverted_index.interactions | 44 |
| abstract_inverted_index.understanding | 18 |
| abstract_inverted_index.cytogenetically | 7 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 17 |
| citation_normalized_percentile |