A miniaturized brain-machine-spinal cord interface (BMSI) for closed-loop intraspinal microstimulation Article Swipe
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· 2016
· Open Access
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· DOI: https://doi.org/10.1109/biocas.2016.7833807
· OA: W2582774316
This paper reports on a fully miniaturized brain-machine-spinal cord interface (BMSI) for closed-loop cortical control of intraspinal microstimulation (ISMS). The system incorporates two identical 4-channel modules, with each module comprising a neural recording front-end, embedded digital signal processing (DSP) unit, and programmable stimulating back-end. The DSP unit is capable of generating multichannel trigger signals for a wide array of ISMS triggering patterns based upon online discrimination of a programmable number of intracortical neural spikes within a pre-specified time bin via thresholding and time-amplitude windowing. The BMSI system is validated experimentally in a rat model of contusion spinal cord injury (SCI) by converting in real-time multichannel neural spikes recorded from the cerebral cortex into electrical stimuli delivered to the lumbar spinal cord below the level of the injury, resulting in distinct patterns of hindlimb muscle activation in the SCI rat.
