A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations Article Swipe
Marco Vanoni
,
Pasquale Palumbo
,
Federico Papa
,
Stefano Busti
,
Laura Gotti
,
Meike T. Wortel
,
Bas Teusink
,
Ivan Orlandi
,
Alex Pessina
,
Cristina Airoldi
,
Luca Brambilla
,
Marina Vai
,
Lilia Alberghina
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.11.25.568635
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.11.25.568635
Summary For unicellular organisms, the reproduction rate and growth are crucial determinants of fitness and, therefore, essential functional manifestations of the organism genotype. Using the budding yeast Saccharomyces cerevisiae as a model organism, we integrated metabolism, which provides energy and building blocks for growth, with cell mass growth and cell cycle progression into a low-granularity, multiscale (from cell to population) computational model. This model predicted that cells with constitutive respiration do not modulate cell size according to the growth conditions. We experimentally validated the model predictions using mutants with defects in the upper part of glycolysis or glucose transport. Plugging in molecular details of cellular subsystems allowed us to refine predictions from the cellular to the molecular level. Our hybrid multiscale modeling approach provides a framework for structuring molecular knowledge and predicting cell phenotypes under various genetic and environmental conditions.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.11.25.568635
- https://www.biorxiv.org/content/biorxiv/early/2023/11/25/2023.11.25.568635.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 94
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389005448
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4389005448Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2023.11.25.568635Digital Object Identifier
- Title
-
A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populationsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-11-25Full publication date if available
- Authors
-
Marco Vanoni, Pasquale Palumbo, Federico Papa, Stefano Busti, Laura Gotti, Meike T. Wortel, Bas Teusink, Ivan Orlandi, Alex Pessina, Cristina Airoldi, Luca Brambilla, Marina Vai, Lilia AlberghinaList of authors in order
- Landing page
-
https://doi.org/10.1101/2023.11.25.568635Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/11/25/2023.11.25.568635.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/11/25/2023.11.25.568635.full.pdfDirect OA link when available
- Concepts
-
Yeast, Saccharomyces cerevisiae, Model organism, Biology, Cell growth, Organism, Cell size, Budding yeast, Cell cycle, Population, Biological system, Cell, Computational biology, Cell biology, Cell metabolism, Systems biology, Genetics, Gene, Demography, SociologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
94Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4389005448 |
|---|---|
| doi | https://doi.org/10.1101/2023.11.25.568635 |
| ids.doi | https://doi.org/10.1101/2023.11.25.568635 |
| ids.openalex | https://openalex.org/W4389005448 |
| fwci | 0.37134082 |
| type | preprint |
| title | A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10497 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Fungal and yeast genetics research |
| topics[1].id | https://openalex.org/T10932 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9994999766349792 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Microbial Metabolic Engineering and Bioproduction |
| topics[2].id | https://openalex.org/T10621 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9980000257492065 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Gene Regulatory Network Analysis |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2779222958 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7299497127532959 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q45422 |
| concepts[0].display_name | Yeast |
| concepts[1].id | https://openalex.org/C2777576037 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6798034310340881 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q719725 |
| concepts[1].display_name | Saccharomyces cerevisiae |
| concepts[2].id | https://openalex.org/C19843653 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5835331678390503 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q213907 |
| concepts[2].display_name | Model organism |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.5810461044311523 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C62112901 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5427960753440857 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q189159 |
| concepts[4].display_name | Cell growth |
| concepts[5].id | https://openalex.org/C137858568 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5370252728462219 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7239 |
| concepts[5].display_name | Organism |
| concepts[6].id | https://openalex.org/C3017597547 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4981667995452881 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q189159 |
| concepts[6].display_name | Cell size |
| concepts[7].id | https://openalex.org/C2992884146 |
| concepts[7].level | 4 |
| concepts[7].score | 0.49651461839675903 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q719725 |
| concepts[7].display_name | Budding yeast |
| concepts[8].id | https://openalex.org/C29537977 |
| concepts[8].level | 3 |
| concepts[8].score | 0.4905626177787781 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q188941 |
| concepts[8].display_name | Cell cycle |
| concepts[9].id | https://openalex.org/C2908647359 |
| concepts[9].level | 2 |
| concepts[9].score | 0.48682111501693726 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[9].display_name | Population |
| concepts[10].id | https://openalex.org/C186060115 |
| concepts[10].level | 1 |
| concepts[10].score | 0.47768908739089966 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q30336093 |
| concepts[10].display_name | Biological system |
| concepts[11].id | https://openalex.org/C1491633281 |
| concepts[11].level | 2 |
| concepts[11].score | 0.4717203974723816 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7868 |
| concepts[11].display_name | Cell |
| concepts[12].id | https://openalex.org/C70721500 |
| concepts[12].level | 1 |
| concepts[12].score | 0.4497336447238922 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[12].display_name | Computational biology |
| concepts[13].id | https://openalex.org/C95444343 |
| concepts[13].level | 1 |
| concepts[13].score | 0.44637805223464966 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[13].display_name | Cell biology |
| concepts[14].id | https://openalex.org/C2991704936 |
| concepts[14].level | 3 |
| concepts[14].score | 0.4391205906867981 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q1057 |
| concepts[14].display_name | Cell metabolism |
| concepts[15].id | https://openalex.org/C152662350 |
| concepts[15].level | 2 |
| concepts[15].score | 0.4174806773662567 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q815297 |
| concepts[15].display_name | Systems biology |
| concepts[16].id | https://openalex.org/C54355233 |
| concepts[16].level | 1 |
| concepts[16].score | 0.2540048360824585 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[16].display_name | Genetics |
| concepts[17].id | https://openalex.org/C104317684 |
| concepts[17].level | 2 |
| concepts[17].score | 0.11656096577644348 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[17].display_name | Gene |
| concepts[18].id | https://openalex.org/C149923435 |
| concepts[18].level | 1 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q37732 |
| concepts[18].display_name | Demography |
| concepts[19].id | https://openalex.org/C144024400 |
| concepts[19].level | 0 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q21201 |
| concepts[19].display_name | Sociology |
| keywords[0].id | https://openalex.org/keywords/yeast |
| keywords[0].score | 0.7299497127532959 |
| keywords[0].display_name | Yeast |
| keywords[1].id | https://openalex.org/keywords/saccharomyces-cerevisiae |
| keywords[1].score | 0.6798034310340881 |
| keywords[1].display_name | Saccharomyces cerevisiae |
| keywords[2].id | https://openalex.org/keywords/model-organism |
| keywords[2].score | 0.5835331678390503 |
| keywords[2].display_name | Model organism |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.5810461044311523 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/cell-growth |
| keywords[4].score | 0.5427960753440857 |
| keywords[4].display_name | Cell growth |
| keywords[5].id | https://openalex.org/keywords/organism |
| keywords[5].score | 0.5370252728462219 |
| keywords[5].display_name | Organism |
| keywords[6].id | https://openalex.org/keywords/cell-size |
| keywords[6].score | 0.4981667995452881 |
| keywords[6].display_name | Cell size |
| keywords[7].id | https://openalex.org/keywords/budding-yeast |
| keywords[7].score | 0.49651461839675903 |
| keywords[7].display_name | Budding yeast |
| keywords[8].id | https://openalex.org/keywords/cell-cycle |
| keywords[8].score | 0.4905626177787781 |
| keywords[8].display_name | Cell cycle |
| keywords[9].id | https://openalex.org/keywords/population |
| keywords[9].score | 0.48682111501693726 |
| keywords[9].display_name | Population |
| keywords[10].id | https://openalex.org/keywords/biological-system |
| keywords[10].score | 0.47768908739089966 |
| keywords[10].display_name | Biological system |
| keywords[11].id | https://openalex.org/keywords/cell |
| keywords[11].score | 0.4717203974723816 |
| keywords[11].display_name | Cell |
| keywords[12].id | https://openalex.org/keywords/computational-biology |
| keywords[12].score | 0.4497336447238922 |
| keywords[12].display_name | Computational biology |
| keywords[13].id | https://openalex.org/keywords/cell-biology |
| keywords[13].score | 0.44637805223464966 |
| keywords[13].display_name | Cell biology |
| keywords[14].id | https://openalex.org/keywords/cell-metabolism |
| keywords[14].score | 0.4391205906867981 |
| keywords[14].display_name | Cell metabolism |
| keywords[15].id | https://openalex.org/keywords/systems-biology |
| keywords[15].score | 0.4174806773662567 |
| keywords[15].display_name | Systems biology |
| keywords[16].id | https://openalex.org/keywords/genetics |
| keywords[16].score | 0.2540048360824585 |
| keywords[16].display_name | Genetics |
| keywords[17].id | https://openalex.org/keywords/gene |
| keywords[17].score | 0.11656096577644348 |
| keywords[17].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1101/2023.11.25.568635 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/11/25/2023.11.25.568635.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2023.11.25.568635 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5063056739 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8690-2587 |
| authorships[0].author.display_name | Marco Vanoni |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[0].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I66752286 |
| authorships[0].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | University of Milano-Bicocca |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Marco Vanoni |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[1].author.id | https://openalex.org/A5069495460 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-9371-2802 |
| authorships[1].author.display_name | Pasquale Palumbo |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[1].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I66752286 |
| authorships[1].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | University of Milano-Bicocca |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Pasquale Palumbo |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[2].author.id | https://openalex.org/A5025543690 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-0263-5697 |
| authorships[2].author.display_name | Federico Papa |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210162062 |
| authorships[2].affiliations[0].raw_affiliation_string | IASI-CNR Via dei Taurini 19, Rome, Italy |
| authorships[2].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I4210162062 |
| authorships[2].institutions[0].ror | https://ror.org/054ye0e45 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210155236, https://openalex.org/I4210162062 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Federico Papa |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | IASI-CNR Via dei Taurini 19, Rome, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[3].author.id | https://openalex.org/A5076124148 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Stefano Busti |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[3].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I66752286 |
| authorships[3].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | University of Milano-Bicocca |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Stefano Busti |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[4].author.id | https://openalex.org/A5029585424 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Laura Gotti |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[4].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I66752286 |
| authorships[4].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | University of Milano-Bicocca |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Laura Gotti |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[5].author.id | https://openalex.org/A5061645901 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-3191-2710 |
| authorships[5].author.display_name | Meike T. Wortel |
| authorships[5].countries | NL |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I887064364 |
| authorships[5].affiliations[0].raw_affiliation_string | Swammerdam Institute for Life Sciences, University of Amsterdam |
| authorships[5].institutions[0].id | https://openalex.org/I887064364 |
| authorships[5].institutions[0].ror | https://ror.org/04dkp9463 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I887064364 |
| authorships[5].institutions[0].country_code | NL |
| authorships[5].institutions[0].display_name | University of Amsterdam |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Meike Wortel |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Swammerdam Institute for Life Sciences, University of Amsterdam |
| authorships[6].author.id | https://openalex.org/A5070958079 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-3929-0423 |
| authorships[6].author.display_name | Bas Teusink |
| authorships[6].countries | NL |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I865915315 |
| authorships[6].affiliations[0].raw_affiliation_string | Systems Biology Lab, AIMMS, VU University, Amsterdam, De Boelelaan 1087, 1081 HV, The Netherlands |
| authorships[6].institutions[0].id | https://openalex.org/I865915315 |
| authorships[6].institutions[0].ror | https://ror.org/008xxew50 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I865915315 |
| authorships[6].institutions[0].country_code | NL |
| authorships[6].institutions[0].display_name | Vrije Universiteit Amsterdam |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Bas Teusink |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Systems Biology Lab, AIMMS, VU University, Amsterdam, De Boelelaan 1087, 1081 HV, The Netherlands |
| authorships[7].author.id | https://openalex.org/A5039207746 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-5799-3213 |
| authorships[7].author.display_name | Ivan Orlandi |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[7].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[7].institutions[0].id | https://openalex.org/I66752286 |
| authorships[7].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | University of Milano-Bicocca |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Ivan Orlandi |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[8].author.id | https://openalex.org/A5016483673 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-4725-7546 |
| authorships[8].author.display_name | Alex Pessina |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[8].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I66752286 |
| authorships[8].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | University of Milano-Bicocca |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Alex Pessina |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[9].author.id | https://openalex.org/A5032149151 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-3670-6262 |
| authorships[9].author.display_name | Cristina Airoldi |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[9].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[9].institutions[0].id | https://openalex.org/I66752286 |
| authorships[9].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | University of Milano-Bicocca |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Cristina Airoldi |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[10].author.id | https://openalex.org/A5103847640 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-0825-2141 |
| authorships[10].author.display_name | Luca Brambilla |
| authorships[10].countries | IT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[10].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[10].institutions[0].id | https://openalex.org/I66752286 |
| authorships[10].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[10].institutions[0].country_code | IT |
| authorships[10].institutions[0].display_name | University of Milano-Bicocca |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Luca Brambilla |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[11].author.id | https://openalex.org/A5047736377 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-1729-2321 |
| authorships[11].author.display_name | Marina Vai |
| authorships[11].countries | IT |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[11].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[11].institutions[0].id | https://openalex.org/I66752286 |
| authorships[11].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[11].institutions[0].country_code | IT |
| authorships[11].institutions[0].display_name | University of Milano-Bicocca |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Marina Vai |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| authorships[12].author.id | https://openalex.org/A5053427006 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-1694-931X |
| authorships[12].author.display_name | Lilia Alberghina |
| authorships[12].countries | IT |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I66752286 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy |
| authorships[12].affiliations[1].raw_affiliation_string | SYSBIO Centre for Systems Biology, Italy |
| authorships[12].institutions[0].id | https://openalex.org/I66752286 |
| authorships[12].institutions[0].ror | https://ror.org/01ynf4891 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I66752286 |
| authorships[12].institutions[0].country_code | IT |
| authorships[12].institutions[0].display_name | University of Milano-Bicocca |
| authorships[12].author_position | last |
| authorships[12].raw_author_name | Lilia Alberghina |
| authorships[12].is_corresponding | True |
| authorships[12].raw_affiliation_strings | Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza , Milan, Italy, SYSBIO Centre for Systems Biology, Italy |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2023/11/25/2023.11.25.568635.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10497 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Fungal and yeast genetics research |
| related_works | https://openalex.org/W2792299140, https://openalex.org/W1924419326, https://openalex.org/W2077148282, https://openalex.org/W160022724, https://openalex.org/W3164718334, https://openalex.org/W2152745412, https://openalex.org/W4254624898, https://openalex.org/W2304538537, https://openalex.org/W2035870580, https://openalex.org/W2346400536 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2023.11.25.568635 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/11/25/2023.11.25.568635.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2023.11.25.568635 |
| primary_location.id | doi:10.1101/2023.11.25.568635 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/11/25/2023.11.25.568635.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2023.11.25.568635 |
| publication_date | 2023-11-25 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2129055445, https://openalex.org/W2931361340, https://openalex.org/W2905898703, https://openalex.org/W1911951809, https://openalex.org/W2011470071, https://openalex.org/W2404660821, https://openalex.org/W2394663426, https://openalex.org/W1979842202, https://openalex.org/W2152652125, https://openalex.org/W1970587132, https://openalex.org/W2110643178, https://openalex.org/W2085519916, https://openalex.org/W2143610637, https://openalex.org/W1550203956, https://openalex.org/W2101807260, https://openalex.org/W2124764610, https://openalex.org/W2030640436, https://openalex.org/W2037928350, https://openalex.org/W2098066769, https://openalex.org/W2127736762, https://openalex.org/W2052543023, https://openalex.org/W2234115940, https://openalex.org/W2098428745, https://openalex.org/W2100507715, https://openalex.org/W2086209631, https://openalex.org/W1590458072, https://openalex.org/W2018003897, https://openalex.org/W2160014215, https://openalex.org/W2058333934, https://openalex.org/W2576890255, https://openalex.org/W2100485294, https://openalex.org/W2033477852, https://openalex.org/W2342528166, https://openalex.org/W1586410868, https://openalex.org/W2145176628, https://openalex.org/W1995948979, https://openalex.org/W2081781433, https://openalex.org/W4292302479, https://openalex.org/W4378071305, https://openalex.org/W1591582819, https://openalex.org/W2101647774, https://openalex.org/W2794704116, https://openalex.org/W2172229929, https://openalex.org/W2100656603, https://openalex.org/W2136344376, https://openalex.org/W2081298797, https://openalex.org/W1986318609, https://openalex.org/W4280529518, https://openalex.org/W2104296952, https://openalex.org/W1979096574, https://openalex.org/W2013184614, https://openalex.org/W2124528660, https://openalex.org/W2337217507, https://openalex.org/W2194184864, https://openalex.org/W1966912773, https://openalex.org/W2068565554, https://openalex.org/W2088127501, https://openalex.org/W2015038174, https://openalex.org/W2078477504, https://openalex.org/W2118956583, https://openalex.org/W2048456744, https://openalex.org/W2107275175, https://openalex.org/W2099257216, https://openalex.org/W2416065856, https://openalex.org/W2967764163, https://openalex.org/W2307026163, https://openalex.org/W2035612098, https://openalex.org/W2962760960, https://openalex.org/W4281648490, https://openalex.org/W4308630670, https://openalex.org/W2133667940, https://openalex.org/W2480908040, https://openalex.org/W2111020654, https://openalex.org/W2142171814, https://openalex.org/W2124436671, https://openalex.org/W1984920104, https://openalex.org/W2123416375, https://openalex.org/W1509558741, https://openalex.org/W1965457851, https://openalex.org/W1995686691, https://openalex.org/W2095209742, https://openalex.org/W2122860350, https://openalex.org/W4221135528, https://openalex.org/W2104187897, https://openalex.org/W2283795047, https://openalex.org/W1968917541, https://openalex.org/W2167279371, https://openalex.org/W2128862717, https://openalex.org/W2412531010, https://openalex.org/W2165630230, https://openalex.org/W1985001103, https://openalex.org/W2024095537, https://openalex.org/W2132416603, https://openalex.org/W2109046686 |
| referenced_works_count | 94 |
| abstract_inverted_index.a | 30, 53, 124 |
| abstract_inverted_index.We | 80 |
| abstract_inverted_index.as | 29 |
| abstract_inverted_index.do | 70 |
| abstract_inverted_index.in | 90, 100 |
| abstract_inverted_index.of | 12, 19, 94, 103 |
| abstract_inverted_index.or | 96 |
| abstract_inverted_index.to | 58, 76, 108, 114 |
| abstract_inverted_index.us | 107 |
| abstract_inverted_index.we | 33 |
| abstract_inverted_index.For | 1 |
| abstract_inverted_index.Our | 118 |
| abstract_inverted_index.and | 7, 39, 48, 130, 137 |
| abstract_inverted_index.are | 9 |
| abstract_inverted_index.for | 42, 126 |
| abstract_inverted_index.not | 71 |
| abstract_inverted_index.the | 4, 20, 24, 77, 83, 91, 112, 115 |
| abstract_inverted_index.This | 62 |
| abstract_inverted_index.and, | 14 |
| abstract_inverted_index.cell | 45, 49, 57, 73, 132 |
| abstract_inverted_index.from | 111 |
| abstract_inverted_index.into | 52 |
| abstract_inverted_index.mass | 46 |
| abstract_inverted_index.part | 93 |
| abstract_inverted_index.rate | 6 |
| abstract_inverted_index.size | 74 |
| abstract_inverted_index.that | 65 |
| abstract_inverted_index.with | 44, 67, 88 |
| abstract_inverted_index.(from | 56 |
| abstract_inverted_index.Using | 23 |
| abstract_inverted_index.cells | 66 |
| abstract_inverted_index.cycle | 50 |
| abstract_inverted_index.model | 31, 63, 84 |
| abstract_inverted_index.under | 134 |
| abstract_inverted_index.upper | 92 |
| abstract_inverted_index.using | 86 |
| abstract_inverted_index.which | 36 |
| abstract_inverted_index.yeast | 26 |
| abstract_inverted_index.blocks | 41 |
| abstract_inverted_index.energy | 38 |
| abstract_inverted_index.growth | 8, 47, 78 |
| abstract_inverted_index.hybrid | 119 |
| abstract_inverted_index.level. | 117 |
| abstract_inverted_index.model. | 61 |
| abstract_inverted_index.refine | 109 |
| abstract_inverted_index.Summary | 0 |
| abstract_inverted_index.allowed | 106 |
| abstract_inverted_index.budding | 25 |
| abstract_inverted_index.crucial | 10 |
| abstract_inverted_index.defects | 89 |
| abstract_inverted_index.details | 102 |
| abstract_inverted_index.fitness | 13 |
| abstract_inverted_index.genetic | 136 |
| abstract_inverted_index.glucose | 97 |
| abstract_inverted_index.growth, | 43 |
| abstract_inverted_index.mutants | 87 |
| abstract_inverted_index.various | 135 |
| abstract_inverted_index.Plugging | 99 |
| abstract_inverted_index.approach | 122 |
| abstract_inverted_index.building | 40 |
| abstract_inverted_index.cellular | 104, 113 |
| abstract_inverted_index.modeling | 121 |
| abstract_inverted_index.modulate | 72 |
| abstract_inverted_index.organism | 21 |
| abstract_inverted_index.provides | 37, 123 |
| abstract_inverted_index.according | 75 |
| abstract_inverted_index.essential | 16 |
| abstract_inverted_index.framework | 125 |
| abstract_inverted_index.genotype. | 22 |
| abstract_inverted_index.knowledge | 129 |
| abstract_inverted_index.molecular | 101, 116, 128 |
| abstract_inverted_index.organism, | 32 |
| abstract_inverted_index.predicted | 64 |
| abstract_inverted_index.validated | 82 |
| abstract_inverted_index.cerevisiae | 28 |
| abstract_inverted_index.functional | 17 |
| abstract_inverted_index.glycolysis | 95 |
| abstract_inverted_index.integrated | 34 |
| abstract_inverted_index.multiscale | 55, 120 |
| abstract_inverted_index.organisms, | 3 |
| abstract_inverted_index.phenotypes | 133 |
| abstract_inverted_index.predicting | 131 |
| abstract_inverted_index.subsystems | 105 |
| abstract_inverted_index.therefore, | 15 |
| abstract_inverted_index.transport. | 98 |
| abstract_inverted_index.conditions. | 79, 139 |
| abstract_inverted_index.metabolism, | 35 |
| abstract_inverted_index.population) | 59 |
| abstract_inverted_index.predictions | 85, 110 |
| abstract_inverted_index.progression | 51 |
| abstract_inverted_index.respiration | 69 |
| abstract_inverted_index.structuring | 127 |
| abstract_inverted_index.unicellular | 2 |
| abstract_inverted_index.constitutive | 68 |
| abstract_inverted_index.determinants | 11 |
| abstract_inverted_index.reproduction | 5 |
| abstract_inverted_index.Saccharomyces | 27 |
| abstract_inverted_index.computational | 60 |
| abstract_inverted_index.environmental | 138 |
| abstract_inverted_index.experimentally | 81 |
| abstract_inverted_index.manifestations | 18 |
| abstract_inverted_index.low-granularity, | 54 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5053427006, https://openalex.org/A5063056739 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I66752286 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.5400000214576721 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.66622676 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |