Journal of Infection • Vol 88 • No 3
A multicentre observational study to investigate feasibility of a direct oral penicillin challenge in de-labelling ‘low risk’ patients with penicillin allergy by non-allergy healthcare professionals (SPACE study): Implications for healthcare systems
February 2024 • Mamidipudi Thirumala Krishna, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Yogini Jani, Iestyn Williams, Jonathan Sandoe, Rachel Pollard, …
DPCs can be delivered by non-allergy HCPs. A high proportion of patients with PALs did not progress in the study pathway. Strategies to deliver DPC at optimal points of the care pathway are needed to enhance uptake. Elective settings offer greater opportunities than acute settings for DPC. The safety and simplicity of DPCs lends itself to adoption by healthcare systems beyond the UK, including in resource-limited settings.