A Multitarget Approach to Evaluate the Efficacy of Aquilaria sinensis Flower Extract against Metabolic Syndrome Article Swipe
Hee‐Sung Chae
,
Olivia R. Dale
,
Tahir Maqbool Mir
,
Bharathi Avula
,
Jianping Zhao
,
Ikhlas A. Khan
,
Shabana I. Khan
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/molecules27030629
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/molecules27030629
Aquilaria sinensis (Lour.) Spreng is known for its resinous secretion (agarwood), often secreted in defense against injuries. We investigated the effects of A. sinensis flower extract (AF) on peroxisome proliferator-activated receptors alpha and gamma (PPARα and PPARγ), liver X receptor (LXR), glucose uptake, and lipid accumulation (adipogenesis). Activation of PPARα, PPARγ and LXR was determined in hepatic (HepG2) cells by reporter gene assays. Glucose uptake was determined in differentiated muscle (C2C12) cells using 2-NBDG (2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose). Adipogenesis was determined in adipocytes (3T3-L1 cells) by Oil red O staining. At a concentration of 50 µg/mL, AF caused 12.2-fold activation of PPARα and 5.7-fold activation of PPARγ, while the activation of LXR was only 1.7-fold. AF inhibited (28%) the adipogenic effect induced by rosiglitazone in adipocytes and increased glucose uptake (32.8%) in muscle cells at 50 μg/mL. It was concluded that AF acted as a PPARα/γ dual agonist without the undesired effect of adipogenesis and exhibited the property of enhancing glucose uptake. This is the first report to reveal the PPARα/γ dual agonistic action and glucose uptake enhancing property of AF along with its antiadipogenic effect, indicating its potential in ameliorating the symptoms of metabolic syndrome.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules27030629
- https://www.mdpi.com/1420-3049/27/3/629/pdf?version=1642577267
- OA Status
- gold
- Cited By
- 13
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4206480386
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4206480386Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/molecules27030629Digital Object Identifier
- Title
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A Multitarget Approach to Evaluate the Efficacy of Aquilaria sinensis Flower Extract against Metabolic SyndromeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-19Full publication date if available
- Authors
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Hee‐Sung Chae, Olivia R. Dale, Tahir Maqbool Mir, Bharathi Avula, Jianping Zhao, Ikhlas A. Khan, Shabana I. KhanList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules27030629Publisher landing page
- PDF URL
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https://www.mdpi.com/1420-3049/27/3/629/pdf?version=1642577267Direct link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.mdpi.com/1420-3049/27/3/629/pdf?version=1642577267Direct OA link when available
- Concepts
-
Adipogenesis, Glucose uptake, Peroxisome, Oil Red O, Rosiglitazone, Peroxisome proliferator-activated receptor, Agonist, Internal medicine, Endocrinology, Chemistry, Receptor, Biochemistry, Biology, Insulin, Adipose tissue, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
13Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 3, 2023: 5Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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