A myelinic channel system for motor-driven organelle transport Article Swipe
Katie J. Chapple
,
Tabitha R. F. Green
,
Sarah Wirth
,
Yi-Hsin Chen
,
Ulrike C. Gerwig
,
Marie Louise Aicher
,
Yeonsu Kim
,
Lina Komarek
,
Angus M. Brown
,
Colin L. Crawford
,
Rebecca Sherrard Smith
,
Jeff Lee
,
Luis Pardo
,
Rebecca E. McHugh
,
Celia M. Kassmann
,
Hauke Werner
,
Ilan Davis
,
Matthias Kneussel
,
Euan R. Brown
,
Sandra Goebbels
,
Klaus‐Armin Nave
,
Julia M. Edgar
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.06.02.591488
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.06.02.591488
Summary Myelin sheaths comprise compacted layers of oligodendroglial membrane wrapped spirally around axons. Each sheath, if imagined unwrapped, has a cytoplasm-filled space at its perimeter, linking it to the oligodendrocyte soma via a short process. By electron microscopy (EM), this space, which we term the ‘ myelinic channel system ’ contains microtubules and membranous organelles, but whether these are remnants of development or serve a function is unknown. Performing live imaging of myelinating oligodendrocytes expressing fluorescent reporters, we found that the myelinic channel system serves microtubule-dependent organelle transport. Further, the intra-myelinic movement of peroxisomes was modulated by neuronal electrical activity in these mixed neural cell cultures. Loss of oligodendroglial Kif21b or CNP in vivo led to apparent stasis of myelin organelles and secondary axon pathology. This suggests that oligodendrocytes require motor transport in myelin to maintain axonal integrity.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.06.02.591488
- https://www.biorxiv.org/content/biorxiv/early/2024/06/03/2024.06.02.591488.full.pdf
- OA Status
- green
- Cited By
- 3
- References
- 131
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399300852
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399300852Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2024.06.02.591488Digital Object Identifier
- Title
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A myelinic channel system for motor-driven organelle transportWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-03Full publication date if available
- Authors
-
Katie J. Chapple, Tabitha R. F. Green, Sarah Wirth, Yi-Hsin Chen, Ulrike C. Gerwig, Marie Louise Aicher, Yeonsu Kim, Lina Komarek, Angus M. Brown, Colin L. Crawford, Rebecca Sherrard Smith, Jeff Lee, Luis Pardo, Rebecca E. McHugh, Celia M. Kassmann, Hauke Werner, Ilan Davis, Matthias Kneussel, Euan R. Brown, Sandra Goebbels, Klaus‐Armin Nave, Julia M. EdgarList of authors in order
- Landing page
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https://doi.org/10.1101/2024.06.02.591488Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2024/06/03/2024.06.02.591488.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2024/06/03/2024.06.02.591488.full.pdfDirect OA link when available
- Concepts
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Organelle, Axoplasmic transport, Chemistry, Channel (broadcasting), Cell biology, Biophysics, Neuroscience, Biology, Computer science, Computer networkTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 1, 2024: 2Per-year citation counts (last 5 years)
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131Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.oligodendrocytes | 73, 128 |
| abstract_inverted_index.oligodendroglial | 7, 108 |
| abstract_inverted_index.microtubule-dependent | 85 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5018944263 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 22 |
| corresponding_institution_ids | https://openalex.org/I7882870 |
| citation_normalized_percentile.value | 0.8126975 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |