A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3 Article Swipe

PDF

Xue Ding , Tongdan Liu , Zhouling Xie , Qi Zhao , Yuan Cao , Xiaodong Liu , Caihui Wang , Rwibasira Rudinga Gamariel , Xin Ming , Zhiyu Li , Yi Kong ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1155/2016/8587164

Integrin α IIb β 3 plays a crucial role in the process of platelet aggregation. Three integrin α IIb β 3 antagonists (abciximab, eptifibatide, and tirofiban) have been approved by FDA for clinical use. Unfortunately, they all showed severe side effects such as thrombocytopenia and bleeding risk. Thus, researches on the development of more effective and safer antiplatelet agents are needed. In this manuscript we reported a novel naphthalenic derivative compound ND-1 with potent antithrombotic effect and lower bleeding risk. ND-1 inhibited ADP-, collagen-, thrombin-, and U46619-induced platelet aggregation with IC 50 values of 1.29, 14.46, 12.84, and 40.24 μ M, respectively. Mechanism studies indicated that ND-1 inhibited the binding of fibrinogen to integrin α IIb β 3 in a dose-dependent manner with an IC 50 value of 3.12 μ M. ND-1 inhibited P-selectin expression induced by ADP, collagen, thrombin, and U46619 on the surface of platelets. Additionally, this compound reduced platelets spreading to the immobilized fibrinogen. In vivo, ND-1 potently decreased thrombus formation in an arteriovenous shunt thrombosis model in rats and slightly prolonged bleeding time in a tail cutting model in mice. Taken together, our results reveal that ND-1 is a novel antagonist of α IIb β 3 with strong antithrombotic effect and lower bleeding risk.

Related Topics

Peripheral Component Interconnect

Myocardial Infarction

Concepts

Tirofiban Antithrombotic Fibrinogen Platelet Integrin Pharmacology Thrombin Abciximab Thrombus Chemistry Clot retraction Eptifibatide Medicine Immunology Biochemistry Internal medicine Receptor Conventional PCI Myocardial infarction

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1155/2016/8587164
PDF: https://downloads.hindawi.com/journals/bmri/2016/8587164.pdf
OA Status: hybrid
Cited By: 4
References: 33
Related Works: 10
OpenAlex ID: https://openalex.org/W2566559571

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W2566559571

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1155/2016/8587164

Digital Object Identifier
Title: A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2016

Year of publication
Publication date: 2016-01-01

Full publication date if available
Authors: Xue Ding, Tongdan Liu, Zhouling Xie, Qi Zhao, Yuan Cao, Xiaodong Liu, Caihui Wang, Rwibasira Rudinga Gamariel, Xin Ming, Zhiyu Li, Yi Kong

List of authors in order
Landing page: https://doi.org/10.1155/2016/8587164

Publisher landing page
PDF URL: https://downloads.hindawi.com/journals/bmri/2016/8587164.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: hybrid

Open access status per OpenAlex
OA URL: https://downloads.hindawi.com/journals/bmri/2016/8587164.pdf

Direct OA link when available
Concepts: Tirofiban, Antithrombotic, Fibrinogen, Platelet, Integrin, Pharmacology, Thrombin, Abciximab, Thrombus, Chemistry, Clot retraction, Eptifibatide, Medicine, Immunology, Biochemistry, Internal medicine, Receptor, Conventional PCI, Myocardial infarction

Top concepts (fields/topics) attached by OpenAlex
Cited by: 4

Total citation count in OpenAlex
Citations by year (recent): 2023: 1, 2021: 1, 2018: 2

Per-year citation counts (last 5 years)
References (count): 33

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W2566559571
doi	https://doi.org/10.1155/2016/8587164
ids.doi	https://doi.org/10.1155/2016/8587164
ids.mag	2566559571
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/28097150
ids.openalex	https://openalex.org/W2566559571
fwci	0.46505408
mesh[0].qualifier_ui
mesh[0].descriptor_ui	D000077284
mesh[0].is_major_topic	False
mesh[0].qualifier_name
mesh[0].descriptor_name	Abciximab
mesh[1].qualifier_ui
mesh[1].descriptor_ui	D000818
mesh[1].is_major_topic	False
mesh[1].qualifier_name
mesh[1].descriptor_name	Animals
mesh[2].qualifier_ui	Q000009
mesh[2].descriptor_ui	D000911
mesh[2].is_major_topic	False
mesh[2].qualifier_name	adverse effects
mesh[2].descriptor_name	Antibodies, Monoclonal
mesh[3].qualifier_ui	Q000627
mesh[3].descriptor_ui	D000911
mesh[3].is_major_topic	False
mesh[3].qualifier_name	therapeutic use
mesh[3].descriptor_name	Antibodies, Monoclonal
mesh[4].qualifier_ui	Q000097
mesh[4].descriptor_ui	D002318
mesh[4].is_major_topic	False
mesh[4].qualifier_name	blood
mesh[4].descriptor_name	Cardiovascular Diseases
mesh[5].qualifier_ui	Q000188
mesh[5].descriptor_ui	D002318
mesh[5].is_major_topic	False
mesh[5].qualifier_name	drug therapy
mesh[5].descriptor_name	Cardiovascular Diseases
mesh[6].qualifier_ui	Q000473
mesh[6].descriptor_ui	D002318
mesh[6].is_major_topic	False
mesh[6].qualifier_name	pathology
mesh[6].descriptor_name	Cardiovascular Diseases
mesh[7].qualifier_ui
mesh[7].descriptor_ui	D004195
mesh[7].is_major_topic	False
mesh[7].qualifier_name
mesh[7].descriptor_name	Disease Models, Animal
mesh[8].qualifier_ui
mesh[8].descriptor_ui	D000077542
mesh[8].is_major_topic	False
mesh[8].qualifier_name
mesh[8].descriptor_name	Eptifibatide
mesh[9].qualifier_ui	Q000378
mesh[9].descriptor_ui	D005340
mesh[9].is_major_topic	False
mesh[9].qualifier_name	metabolism
mesh[9].descriptor_name	Fibrinogen
mesh[10].qualifier_ui	Q000139
mesh[10].descriptor_ui	D006470
mesh[10].is_major_topic	False
mesh[10].qualifier_name	chemically induced
mesh[10].descriptor_name	Hemorrhage
mesh[11].qualifier_ui	Q000188
mesh[11].descriptor_ui	D006470
mesh[11].is_major_topic	False
mesh[11].qualifier_name	drug therapy
mesh[11].descriptor_name	Hemorrhage
mesh[12].qualifier_ui	Q000473
mesh[12].descriptor_ui	D006470
mesh[12].is_major_topic	False
mesh[12].qualifier_name	pathology
mesh[12].descriptor_name	Hemorrhage
mesh[13].qualifier_ui
mesh[13].descriptor_ui	D006801
mesh[13].is_major_topic	False
mesh[13].qualifier_name
mesh[13].descriptor_name	Humans
mesh[14].qualifier_ui	Q000009
mesh[14].descriptor_ui	D007140
mesh[14].is_major_topic	False
mesh[14].qualifier_name	adverse effects
mesh[14].descriptor_name	Immunoglobulin Fab Fragments
mesh[15].qualifier_ui	Q000627
mesh[15].descriptor_ui	D007140
mesh[15].is_major_topic	False
mesh[15].qualifier_name	therapeutic use
mesh[15].descriptor_name	Immunoglobulin Fab Fragments
mesh[16].qualifier_ui	Q000378
mesh[16].descriptor_ui	D039421
mesh[16].is_major_topic	False
mesh[16].qualifier_name	metabolism
mesh[16].descriptor_name	Integrin alpha2
mesh[17].qualifier_ui	Q000378
mesh[17].descriptor_ui	D039661
mesh[17].is_major_topic	False
mesh[17].qualifier_name	metabolism
mesh[17].descriptor_name	Integrin beta3
mesh[18].qualifier_ui
mesh[18].descriptor_ui	D051379
mesh[18].is_major_topic	False
mesh[18].qualifier_name
mesh[18].descriptor_name	Mice
mesh[19].qualifier_ui	Q000008
mesh[19].descriptor_ui	D009281
mesh[19].is_major_topic	False
mesh[19].qualifier_name	administration & dosage
mesh[19].descriptor_name	Naphthalenes
mesh[20].qualifier_ui	Q000009
mesh[20].descriptor_ui	D010455
mesh[20].is_major_topic	False
mesh[20].qualifier_name	adverse effects
mesh[20].descriptor_name	Peptides
mesh[21].qualifier_ui	Q000627
mesh[21].descriptor_ui	D010455
mesh[21].is_major_topic	False
mesh[21].qualifier_name	therapeutic use
mesh[21].descriptor_name	Peptides
mesh[22].qualifier_ui	Q000187
mesh[22].descriptor_ui	D010974
mesh[22].is_major_topic	False
mesh[22].qualifier_name	drug effects
mesh[22].descriptor_name	Platelet Aggregation
mesh[23].qualifier_ui
mesh[23].descriptor_ui	D051381
mesh[23].is_major_topic	False
mesh[23].qualifier_name
mesh[23].descriptor_name	Rats
mesh[24].qualifier_ui	Q000139
mesh[24].descriptor_ui	D013921
mesh[24].is_major_topic	False
mesh[24].qualifier_name	chemically induced
mesh[24].descriptor_name	Thrombocytopenia
mesh[25].qualifier_ui	Q000188
mesh[25].descriptor_ui	D013921
mesh[25].is_major_topic	False
mesh[25].qualifier_name	drug therapy
mesh[25].descriptor_name	Thrombocytopenia
mesh[26].qualifier_ui	Q000473
mesh[26].descriptor_ui	D013921
mesh[26].is_major_topic	False
mesh[26].qualifier_name	pathology
mesh[26].descriptor_name	Thrombocytopenia
mesh[27].qualifier_ui	Q000188
mesh[27].descriptor_ui	D013927
mesh[27].is_major_topic	False
mesh[27].qualifier_name	drug therapy
mesh[27].descriptor_name	Thrombosis
mesh[28].qualifier_ui	Q000473
mesh[28].descriptor_ui	D013927
mesh[28].is_major_topic	False
mesh[28].qualifier_name	pathology
mesh[28].descriptor_name	Thrombosis
mesh[29].qualifier_ui
mesh[29].descriptor_ui	D000077466
mesh[29].is_major_topic	False
mesh[29].qualifier_name
mesh[29].descriptor_name	Tirofiban
mesh[30].qualifier_ui	Q000009
mesh[30].descriptor_ui	D014443
mesh[30].is_major_topic	False
mesh[30].qualifier_name	adverse effects
mesh[30].descriptor_name	Tyrosine
mesh[31].qualifier_ui	Q000031
mesh[31].descriptor_ui	D014443
mesh[31].is_major_topic	False
mesh[31].qualifier_name	analogs & derivatives
mesh[31].descriptor_name	Tyrosine
mesh[32].qualifier_ui	Q000627
mesh[32].descriptor_ui	D014443
mesh[32].is_major_topic	False
mesh[32].qualifier_name	therapeutic use
mesh[32].descriptor_name	Tyrosine
mesh[33].qualifier_ui
mesh[33].descriptor_ui	D000077284
mesh[33].is_major_topic	False
mesh[33].qualifier_name
mesh[33].descriptor_name	Abciximab
mesh[34].qualifier_ui
mesh[34].descriptor_ui	D000818
mesh[34].is_major_topic	False
mesh[34].qualifier_name
mesh[34].descriptor_name	Animals
mesh[35].qualifier_ui	Q000009
mesh[35].descriptor_ui	D000911
mesh[35].is_major_topic	False
mesh[35].qualifier_name	adverse effects
mesh[35].descriptor_name	Antibodies, Monoclonal
mesh[36].qualifier_ui	Q000627
mesh[36].descriptor_ui	D000911
mesh[36].is_major_topic	False
mesh[36].qualifier_name	therapeutic use
mesh[36].descriptor_name	Antibodies, Monoclonal
mesh[37].qualifier_ui	Q000097
mesh[37].descriptor_ui	D002318
mesh[37].is_major_topic	False
mesh[37].qualifier_name	blood
mesh[37].descriptor_name	Cardiovascular Diseases
mesh[38].qualifier_ui	Q000188
mesh[38].descriptor_ui	D002318
mesh[38].is_major_topic	False
mesh[38].qualifier_name	drug therapy
mesh[38].descriptor_name	Cardiovascular Diseases
mesh[39].qualifier_ui	Q000473
mesh[39].descriptor_ui	D002318
mesh[39].is_major_topic	False
mesh[39].qualifier_name	pathology
mesh[39].descriptor_name	Cardiovascular Diseases
mesh[40].qualifier_ui
mesh[40].descriptor_ui	D004195
mesh[40].is_major_topic	False
mesh[40].qualifier_name
mesh[40].descriptor_name	Disease Models, Animal
mesh[41].qualifier_ui
mesh[41].descriptor_ui	D000077542
mesh[41].is_major_topic	False
mesh[41].qualifier_name
mesh[41].descriptor_name	Eptifibatide
mesh[42].qualifier_ui	Q000378
mesh[42].descriptor_ui	D005340
mesh[42].is_major_topic	False
mesh[42].qualifier_name	metabolism
mesh[42].descriptor_name	Fibrinogen
mesh[43].qualifier_ui	Q000139
mesh[43].descriptor_ui	D006470
mesh[43].is_major_topic	False
mesh[43].qualifier_name	chemically induced
mesh[43].descriptor_name	Hemorrhage
mesh[44].qualifier_ui	Q000188
mesh[44].descriptor_ui	D006470
mesh[44].is_major_topic	False
mesh[44].qualifier_name	drug therapy
mesh[44].descriptor_name	Hemorrhage
mesh[45].qualifier_ui	Q000473
mesh[45].descriptor_ui	D006470
mesh[45].is_major_topic	False
mesh[45].qualifier_name	pathology
mesh[45].descriptor_name	Hemorrhage
mesh[46].qualifier_ui
mesh[46].descriptor_ui	D006801
mesh[46].is_major_topic	False
mesh[46].qualifier_name
mesh[46].descriptor_name	Humans
mesh[47].qualifier_ui	Q000009
mesh[47].descriptor_ui	D007140
mesh[47].is_major_topic	False
mesh[47].qualifier_name	adverse effects
mesh[47].descriptor_name	Immunoglobulin Fab Fragments
mesh[48].qualifier_ui	Q000627
mesh[48].descriptor_ui	D007140
mesh[48].is_major_topic	False
mesh[48].qualifier_name	therapeutic use
mesh[48].descriptor_name	Immunoglobulin Fab Fragments
mesh[49].qualifier_ui	Q000378
mesh[49].descriptor_ui	D039421
mesh[49].is_major_topic	False
mesh[49].qualifier_name	metabolism
mesh[49].descriptor_name	Integrin alpha2
type	article
title	A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3
awards[0].id	https://openalex.org/G1091043992
awards[0].funder_id	https://openalex.org/F4320321001
awards[0].display_name
awards[0].funder_award_id	81273375
awards[0].funder_display_name	National Natural Science Foundation of China
biblio.issue
biblio.volume	2016
biblio.last_page	8
biblio.first_page	1
topics[0].id	https://openalex.org/T10746
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9998999834060669
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2720
topics[0].subfield.display_name	Hematology
topics[0].display_name	Platelet Disorders and Treatments
topics[1].id	https://openalex.org/T11064
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9980000257492065
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2705
topics[1].subfield.display_name	Cardiology and Cardiovascular Medicine
topics[1].display_name	Antiplatelet Therapy and Cardiovascular Diseases
topics[2].id	https://openalex.org/T10831
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9966999888420105
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2723
topics[2].subfield.display_name	Immunology and Allergy
topics[2].display_name	Cell Adhesion Molecules Research
funders[0].id	https://openalex.org/F4320321001
funders[0].ror	https://ror.org/01h0zpd94
funders[0].display_name	National Natural Science Foundation of China
is_xpac	False
apc_list.value	2400
apc_list.currency	USD
apc_list.value_usd	2400
apc_paid.value	2400
apc_paid.currency	USD
apc_paid.value_usd	2400
concepts[0].id	https://openalex.org/C2776335557
concepts[0].level	4
concepts[0].score	0.7805880308151245
concepts[0].wikidata	https://www.wikidata.org/wiki/Q415366
concepts[0].display_name	Tirofiban
concepts[1].id	https://openalex.org/C2777015399
concepts[1].level	2
concepts[1].score	0.713876485824585
concepts[1].wikidata	https://www.wikidata.org/wiki/Q4775337
concepts[1].display_name	Antithrombotic
concepts[2].id	https://openalex.org/C2779036427
concepts[2].level	2
concepts[2].score	0.7117013931274414
concepts[2].wikidata	https://www.wikidata.org/wiki/Q381899
concepts[2].display_name	Fibrinogen
concepts[3].id	https://openalex.org/C89560881
concepts[3].level	2
concepts[3].score	0.6608684062957764
concepts[3].wikidata	https://www.wikidata.org/wiki/Q101026
concepts[3].display_name	Platelet
concepts[4].id	https://openalex.org/C195687474
concepts[4].level	3
concepts[4].score	0.6049959659576416
concepts[4].wikidata	https://www.wikidata.org/wiki/Q409715
concepts[4].display_name	Integrin
concepts[5].id	https://openalex.org/C98274493
concepts[5].level	1
concepts[5].score	0.5587074756622314
concepts[5].wikidata	https://www.wikidata.org/wiki/Q128406
concepts[5].display_name	Pharmacology
concepts[6].id	https://openalex.org/C2777292125
concepts[6].level	3
concepts[6].score	0.5328875780105591
concepts[6].wikidata	https://www.wikidata.org/wiki/Q409166
concepts[6].display_name	Thrombin
concepts[7].id	https://openalex.org/C2777871224
concepts[7].level	4
concepts[7].score	0.5209013819694519
concepts[7].wikidata	https://www.wikidata.org/wiki/Q307088
concepts[7].display_name	Abciximab
concepts[8].id	https://openalex.org/C2781362458
concepts[8].level	2
concepts[8].score	0.514351487159729
concepts[8].wikidata	https://www.wikidata.org/wiki/Q1588755
concepts[8].display_name	Thrombus
concepts[9].id	https://openalex.org/C185592680
concepts[9].level	0
concepts[9].score	0.4894665479660034
concepts[9].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[9].display_name	Chemistry
concepts[10].id	https://openalex.org/C2778863912
concepts[10].level	4
concepts[10].score	0.4742024540901184
concepts[10].wikidata	https://www.wikidata.org/wiki/Q5135535
concepts[10].display_name	Clot retraction
concepts[11].id	https://openalex.org/C2781056559
concepts[11].level	4
concepts[11].score	0.4161866307258606
concepts[11].wikidata	https://www.wikidata.org/wiki/Q2295855
concepts[11].display_name	Eptifibatide
concepts[12].id	https://openalex.org/C71924100
concepts[12].level	0
concepts[12].score	0.4055804908275604
concepts[12].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[12].display_name	Medicine
concepts[13].id	https://openalex.org/C203014093
concepts[13].level	1
concepts[13].score	0.26310300827026367
concepts[13].wikidata	https://www.wikidata.org/wiki/Q101929
concepts[13].display_name	Immunology
concepts[14].id	https://openalex.org/C55493867
concepts[14].level	1
concepts[14].score	0.25865721702575684
concepts[14].wikidata	https://www.wikidata.org/wiki/Q7094
concepts[14].display_name	Biochemistry
concepts[15].id	https://openalex.org/C126322002
concepts[15].level	1
concepts[15].score	0.242244154214859
concepts[15].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[15].display_name	Internal medicine
concepts[16].id	https://openalex.org/C170493617
concepts[16].level	2
concepts[16].score	0.12077876925468445
concepts[16].wikidata	https://www.wikidata.org/wiki/Q208467
concepts[16].display_name	Receptor
concepts[17].id	https://openalex.org/C45393284
concepts[17].level	3
concepts[17].score	0.051001667976379395
concepts[17].wikidata	https://www.wikidata.org/wiki/Q191012
concepts[17].display_name	Conventional PCI
concepts[18].id	https://openalex.org/C500558357
concepts[18].level	2
concepts[18].score	0.0
concepts[18].wikidata	https://www.wikidata.org/wiki/Q12152
concepts[18].display_name	Myocardial infarction
keywords[0].id	https://openalex.org/keywords/tirofiban
keywords[0].score	0.7805880308151245
keywords[0].display_name	Tirofiban
keywords[1].id	https://openalex.org/keywords/antithrombotic
keywords[1].score	0.713876485824585
keywords[1].display_name	Antithrombotic
keywords[2].id	https://openalex.org/keywords/fibrinogen
keywords[2].score	0.7117013931274414
keywords[2].display_name	Fibrinogen
keywords[3].id	https://openalex.org/keywords/platelet
keywords[3].score	0.6608684062957764
keywords[3].display_name	Platelet
keywords[4].id	https://openalex.org/keywords/integrin
keywords[4].score	0.6049959659576416
keywords[4].display_name	Integrin
keywords[5].id	https://openalex.org/keywords/pharmacology
keywords[5].score	0.5587074756622314
keywords[5].display_name	Pharmacology
keywords[6].id	https://openalex.org/keywords/thrombin
keywords[6].score	0.5328875780105591
keywords[6].display_name	Thrombin
keywords[7].id	https://openalex.org/keywords/abciximab
keywords[7].score	0.5209013819694519
keywords[7].display_name	Abciximab
keywords[8].id	https://openalex.org/keywords/thrombus
keywords[8].score	0.514351487159729
keywords[8].display_name	Thrombus
keywords[9].id	https://openalex.org/keywords/chemistry
keywords[9].score	0.4894665479660034
keywords[9].display_name	Chemistry
keywords[10].id	https://openalex.org/keywords/clot-retraction
keywords[10].score	0.4742024540901184
keywords[10].display_name	Clot retraction
keywords[11].id	https://openalex.org/keywords/eptifibatide
keywords[11].score	0.4161866307258606
keywords[11].display_name	Eptifibatide
keywords[12].id	https://openalex.org/keywords/medicine
keywords[12].score	0.4055804908275604
keywords[12].display_name	Medicine
keywords[13].id	https://openalex.org/keywords/immunology
keywords[13].score	0.26310300827026367
keywords[13].display_name	Immunology
keywords[14].id	https://openalex.org/keywords/biochemistry
keywords[14].score	0.25865721702575684
keywords[14].display_name	Biochemistry
keywords[15].id	https://openalex.org/keywords/internal-medicine
keywords[15].score	0.242244154214859
keywords[15].display_name	Internal medicine
keywords[16].id	https://openalex.org/keywords/receptor
keywords[16].score	0.12077876925468445
keywords[16].display_name	Receptor
keywords[17].id	https://openalex.org/keywords/conventional-pci
keywords[17].score	0.051001667976379395
keywords[17].display_name	Conventional PCI
language	en
locations[0].id	doi:10.1155/2016/8587164
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S1010394304
locations[0].source.issn	2314-6133, 2314-6141
locations[0].source.type	journal
locations[0].source.is_oa	False
locations[0].source.issn_l	2314-6133
locations[0].source.is_core	True
locations[0].source.is_in_doaj	False
locations[0].source.display_name	BioMed Research International
locations[0].source.host_organization	https://openalex.org/P4310319869
locations[0].source.host_organization_name	Hindawi Publishing Corporation
locations[0].source.host_organization_lineage	https://openalex.org/P4310319869
locations[0].source.host_organization_lineage_names	Hindawi Publishing Corporation
locations[0].license	cc-by
locations[0].pdf_url	https://downloads.hindawi.com/journals/bmri/2016/8587164.pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	BioMed Research International
locations[0].landing_page_url	https://doi.org/10.1155/2016/8587164
locations[1].id	pmid:28097150
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	BioMed research international
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/28097150
locations[2].id	pmh:oai:doaj.org/article:a17983ecbe2b4109a42570eb4455dcf8
locations[2].is_oa	False
locations[2].source.id	https://openalex.org/S4306401280
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	DOAJ (DOAJ: Directory of Open Access Journals)
locations[2].source.host_organization
locations[2].source.host_organization_name
locations[2].license
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	article
locations[2].license_id
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name	BioMed Research International, Vol 2016 (2016)
locations[2].landing_page_url	https://doaj.org/article/a17983ecbe2b4109a42570eb4455dcf8
locations[3].id	pmh:oai:pubmedcentral.nih.gov:5206433
locations[3].is_oa	True
locations[3].source.id	https://openalex.org/S2764455111
locations[3].source.issn
locations[3].source.type	repository
locations[3].source.is_oa	False
locations[3].source.issn_l
locations[3].source.is_core	False
locations[3].source.is_in_doaj	False
locations[3].source.display_name	PubMed Central
locations[3].source.host_organization	https://openalex.org/I1299303238
locations[3].source.host_organization_name	National Institutes of Health
locations[3].source.host_organization_lineage	https://openalex.org/I1299303238
locations[3].license
locations[3].pdf_url
locations[3].version	submittedVersion
locations[3].raw_type	Text
locations[3].license_id
locations[3].is_accepted	False
locations[3].is_published	False
locations[3].raw_source_name	Biomed Res Int
locations[3].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/5206433
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5043905375
authorships[0].author.orcid	https://orcid.org/0009-0008-2311-5579
authorships[0].author.display_name	Xue Ding
authorships[0].countries	CN
authorships[0].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[0].affiliations[0].raw_affiliation_string	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[0].institutions[0].id	https://openalex.org/I161716053
authorships[0].institutions[0].ror	https://ror.org/01sfm2718
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I161716053
authorships[0].institutions[0].country_code	CN
authorships[0].institutions[0].display_name	China Pharmaceutical University
authorships[0].author_position	first
authorships[0].raw_author_name	Xue Ding
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[1].author.id	https://openalex.org/A5058242360
authorships[1].author.orcid
authorships[1].author.display_name	Tongdan Liu
authorships[1].countries	CN
authorships[1].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[1].affiliations[0].raw_affiliation_string	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[1].institutions[0].id	https://openalex.org/I161716053
authorships[1].institutions[0].ror	https://ror.org/01sfm2718
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I161716053
authorships[1].institutions[0].country_code	CN
authorships[1].institutions[0].display_name	China Pharmaceutical University
authorships[1].author_position	middle
authorships[1].raw_author_name	Tong-dan Liu
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[2].author.id	https://openalex.org/A5024887555
authorships[2].author.orcid	https://orcid.org/0000-0001-5864-304X
authorships[2].author.display_name	Zhouling Xie
authorships[2].countries	CN
authorships[2].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[2].affiliations[0].raw_affiliation_string	School of Pharmacy, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[2].institutions[0].id	https://openalex.org/I161716053
authorships[2].institutions[0].ror	https://ror.org/01sfm2718
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I161716053
authorships[2].institutions[0].country_code	CN
authorships[2].institutions[0].display_name	China Pharmaceutical University
authorships[2].author_position	middle
authorships[2].raw_author_name	Zhou-ling Xie
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	School of Pharmacy, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[3].author.id	https://openalex.org/A5101591674
authorships[3].author.orcid	https://orcid.org/0000-0002-3765-6025
authorships[3].author.display_name	Qi Zhao
authorships[3].countries	CN
authorships[3].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[3].affiliations[0].raw_affiliation_string	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[3].institutions[0].id	https://openalex.org/I161716053
authorships[3].institutions[0].ror	https://ror.org/01sfm2718
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I161716053
authorships[3].institutions[0].country_code	CN
authorships[3].institutions[0].display_name	China Pharmaceutical University
authorships[3].author_position	middle
authorships[3].raw_author_name	Qi Zhao
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[4].author.id	https://openalex.org/A5100925680
authorships[4].author.orcid	https://orcid.org/0000-0001-6176-3472
authorships[4].author.display_name	Yuan Cao
authorships[4].countries	CN
authorships[4].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[4].affiliations[0].raw_affiliation_string	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[4].institutions[0].id	https://openalex.org/I161716053
authorships[4].institutions[0].ror	https://ror.org/01sfm2718
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I161716053
authorships[4].institutions[0].country_code	CN
authorships[4].institutions[0].display_name	China Pharmaceutical University
authorships[4].author_position	middle
authorships[4].raw_author_name	Yuan Cao
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[5].author.id	https://openalex.org/A5100318783
authorships[5].author.orcid	https://orcid.org/0000-0003-1354-4798
authorships[5].author.display_name	Xiaodong Liu
authorships[5].countries	CN
authorships[5].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[5].affiliations[0].raw_affiliation_string	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[5].institutions[0].id	https://openalex.org/I161716053
authorships[5].institutions[0].ror	https://ror.org/01sfm2718
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I161716053
authorships[5].institutions[0].country_code	CN
authorships[5].institutions[0].display_name	China Pharmaceutical University
authorships[5].author_position	middle
authorships[5].raw_author_name	Xiao-dong Liu
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[6].author.id	https://openalex.org/A5070070520
authorships[6].author.orcid
authorships[6].author.display_name	Caihui Wang
authorships[6].countries	CN
authorships[6].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[6].affiliations[0].raw_affiliation_string	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[6].institutions[0].id	https://openalex.org/I161716053
authorships[6].institutions[0].ror	https://ror.org/01sfm2718
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I161716053
authorships[6].institutions[0].country_code	CN
authorships[6].institutions[0].display_name	China Pharmaceutical University
authorships[6].author_position	middle
authorships[6].raw_author_name	Cai-hui Wang
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[7].author.id	https://openalex.org/A5063663397
authorships[7].author.orcid
authorships[7].author.display_name	Rwibasira Rudinga Gamariel
authorships[7].countries	CN
authorships[7].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[7].affiliations[0].raw_affiliation_string	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[7].institutions[0].id	https://openalex.org/I161716053
authorships[7].institutions[0].ror	https://ror.org/01sfm2718
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I161716053
authorships[7].institutions[0].country_code	CN
authorships[7].institutions[0].display_name	China Pharmaceutical University
authorships[7].author_position	middle
authorships[7].raw_author_name	Rwibasira Rudinga Gamariel
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[8].author.id	https://openalex.org/A5082977601
authorships[8].author.orcid	https://orcid.org/0000-0001-8368-250X
authorships[8].author.display_name	Xin Ming
authorships[8].countries	US
authorships[8].affiliations[0].institution_ids	https://openalex.org/I47251452
authorships[8].affiliations[0].raw_affiliation_string	Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
authorships[8].institutions[0].id	https://openalex.org/I47251452
authorships[8].institutions[0].ror	https://ror.org/0207ad724
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I47251452
authorships[8].institutions[0].country_code	US
authorships[8].institutions[0].display_name	Wake Forest University
authorships[8].author_position	middle
authorships[8].raw_author_name	Xin Ming
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
authorships[9].author.id	https://openalex.org/A5100390293
authorships[9].author.orcid
authorships[9].author.display_name	Zhiyu Li
authorships[9].countries	CN
authorships[9].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[9].affiliations[0].raw_affiliation_string	School of Pharmacy, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[9].institutions[0].id	https://openalex.org/I161716053
authorships[9].institutions[0].ror	https://ror.org/01sfm2718
authorships[9].institutions[0].type	education
authorships[9].institutions[0].lineage	https://openalex.org/I161716053
authorships[9].institutions[0].country_code	CN
authorships[9].institutions[0].display_name	China Pharmaceutical University
authorships[9].author_position	middle
authorships[9].raw_author_name	Zhi-yu Li
authorships[9].is_corresponding	True
authorships[9].raw_affiliation_strings	School of Pharmacy, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[10].author.id	https://openalex.org/A5014820919
authorships[10].author.orcid	https://orcid.org/0000-0002-2329-7009
authorships[10].author.display_name	Yi Kong
authorships[10].countries	CN
authorships[10].affiliations[0].institution_ids	https://openalex.org/I161716053
authorships[10].affiliations[0].raw_affiliation_string	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[10].affiliations[1].institution_ids	https://openalex.org/I161716053
authorships[10].affiliations[1].raw_affiliation_string	State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
authorships[10].institutions[0].id	https://openalex.org/I161716053
authorships[10].institutions[0].ror	https://ror.org/01sfm2718
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I161716053
authorships[10].institutions[0].country_code	CN
authorships[10].institutions[0].display_name	China Pharmaceutical University
authorships[10].author_position	last
authorships[10].raw_author_name	Yi Kong
authorships[10].is_corresponding	True
authorships[10].raw_affiliation_strings	School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://downloads.hindawi.com/journals/bmri/2016/8587164.pdf
open_access.oa_status	hybrid
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10746
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9998999834060669
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2720
primary_topic.subfield.display_name	Hematology
primary_topic.display_name	Platelet Disorders and Treatments
related_works	https://openalex.org/W1977588823, https://openalex.org/W2410568339, https://openalex.org/W2318692108, https://openalex.org/W2154865640, https://openalex.org/W1677809529, https://openalex.org/W2163292105, https://openalex.org/W1994543623, https://openalex.org/W1606321300, https://openalex.org/W2089451440, https://openalex.org/W2149204409
cited_by_count	4
counts_by_year[0].year	2023
counts_by_year[0].cited_by_count	1
counts_by_year[1].year	2021
counts_by_year[1].cited_by_count	1
counts_by_year[2].year	2018
counts_by_year[2].cited_by_count	2
locations_count	4
best_oa_location.id	doi:10.1155/2016/8587164
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S1010394304
best_oa_location.source.issn	2314-6133, 2314-6141
best_oa_location.source.type	journal
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l	2314-6133
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	BioMed Research International
best_oa_location.source.host_organization	https://openalex.org/P4310319869
best_oa_location.source.host_organization_name	Hindawi Publishing Corporation
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310319869
best_oa_location.source.host_organization_lineage_names	Hindawi Publishing Corporation
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://downloads.hindawi.com/journals/bmri/2016/8587164.pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	BioMed Research International
best_oa_location.landing_page_url	https://doi.org/10.1155/2016/8587164
primary_location.id	doi:10.1155/2016/8587164
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S1010394304
primary_location.source.issn	2314-6133, 2314-6141
primary_location.source.type	journal
primary_location.source.is_oa	False
primary_location.source.issn_l	2314-6133
primary_location.source.is_core	True
primary_location.source.is_in_doaj	False
primary_location.source.display_name	BioMed Research International
primary_location.source.host_organization	https://openalex.org/P4310319869
primary_location.source.host_organization_name	Hindawi Publishing Corporation
primary_location.source.host_organization_lineage	https://openalex.org/P4310319869
primary_location.source.host_organization_lineage_names	Hindawi Publishing Corporation
primary_location.license	cc-by
primary_location.pdf_url	https://downloads.hindawi.com/journals/bmri/2016/8587164.pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	BioMed Research International
primary_location.landing_page_url	https://doi.org/10.1155/2016/8587164
publication_date	2016-01-01
publication_year	2016
referenced_works	https://openalex.org/W1709778167, https://openalex.org/W1975308676, https://openalex.org/W2116024419, https://openalex.org/W2029798453, https://openalex.org/W1998644636, https://openalex.org/W2038437813, https://openalex.org/W2053917461, https://openalex.org/W2080365739, https://openalex.org/W2037918168, https://openalex.org/W2154210764, https://openalex.org/W1985410128, https://openalex.org/W2064739148, https://openalex.org/W1964274124, https://openalex.org/W1975657979, https://openalex.org/W2063262989, https://openalex.org/W2120685031, https://openalex.org/W1970312745, https://openalex.org/W2002042988, https://openalex.org/W2061922506, https://openalex.org/W2321360567, https://openalex.org/W1985505773, https://openalex.org/W2168045254, https://openalex.org/W1987244301, https://openalex.org/W2018040437, https://openalex.org/W2103888323, https://openalex.org/W2110142425, https://openalex.org/W1490935970, https://openalex.org/W2015047954, https://openalex.org/W2045251048, https://openalex.org/W2113192711, https://openalex.org/W2113264950, https://openalex.org/W2168173102, https://openalex.org/W4251470689
referenced_works_count	33
abstract_inverted_index.3	4, 20, 117, 199
abstract_inverted_index.a	6, 66, 119, 178, 192
abstract_inverted_index.50	91, 125
abstract_inverted_index.IC	90, 124
abstract_inverted_index.In	61, 157
abstract_inverted_index.M,	100
abstract_inverted_index.M.	130
abstract_inverted_index.an	123, 165
abstract_inverted_index.as	42
abstract_inverted_index.by	29, 136
abstract_inverted_index.in	9, 118, 164, 170, 177, 182
abstract_inverted_index.is	191
abstract_inverted_index.of	12, 52, 93, 110, 127, 145, 195
abstract_inverted_index.on	49, 142
abstract_inverted_index.to	112, 153
abstract_inverted_index.we	64
abstract_inverted_index.α	1, 17, 114, 196
abstract_inverted_index.β	3, 19, 116, 198
abstract_inverted_index.μ	99, 129
abstract_inverted_index.FDA	30
abstract_inverted_index.IIb	2, 18, 115, 197
abstract_inverted_index.all	36
abstract_inverted_index.and	24, 44, 55, 76, 85, 97, 140, 172, 204
abstract_inverted_index.are	59
abstract_inverted_index.for	31
abstract_inverted_index.our	186
abstract_inverted_index.the	10, 50, 108, 143, 154
abstract_inverted_index.3.12	128
abstract_inverted_index.ADP,	137
abstract_inverted_index.ND-1	71, 80, 106, 131, 159, 190
abstract_inverted_index.been	27
abstract_inverted_index.have	26
abstract_inverted_index.more	53
abstract_inverted_index.rats	171
abstract_inverted_index.role	8
abstract_inverted_index.side	39
abstract_inverted_index.such	41
abstract_inverted_index.tail	179
abstract_inverted_index.that	105, 189
abstract_inverted_index.they	35
abstract_inverted_index.this	62, 148
abstract_inverted_index.time	176
abstract_inverted_index.use.	33
abstract_inverted_index.with	72, 89, 122, 200
abstract_inverted_index.1.29,	94
abstract_inverted_index.40.24	98
abstract_inverted_index.ADP-,	82
abstract_inverted_index.Taken	184
abstract_inverted_index.Three	15
abstract_inverted_index.Thus,	47
abstract_inverted_index.lower	77, 205
abstract_inverted_index.mice.	183
abstract_inverted_index.model	169, 181
abstract_inverted_index.novel	67, 193
abstract_inverted_index.plays	5
abstract_inverted_index.risk.	46, 79, 207
abstract_inverted_index.safer	56
abstract_inverted_index.shunt	167
abstract_inverted_index.value	126
abstract_inverted_index.vivo,	158
abstract_inverted_index.12.84,	96
abstract_inverted_index.14.46,	95
abstract_inverted_index.U46619	141
abstract_inverted_index.agents	58
abstract_inverted_index.effect	75, 203
abstract_inverted_index.manner	121
abstract_inverted_index.potent	73
abstract_inverted_index.reveal	188
abstract_inverted_index.severe	38
abstract_inverted_index.showed	37
abstract_inverted_index.strong	201
abstract_inverted_index.values	92
abstract_inverted_index.binding	109
abstract_inverted_index.crucial	7
abstract_inverted_index.cutting	180
abstract_inverted_index.effects	40
abstract_inverted_index.induced	135
abstract_inverted_index.needed.	60
abstract_inverted_index.process	11
abstract_inverted_index.reduced	150
abstract_inverted_index.results	187
abstract_inverted_index.studies	103
abstract_inverted_index.surface	144
abstract_inverted_index.Integrin	0
abstract_inverted_index.approved	28
abstract_inverted_index.bleeding	45, 78, 175, 206
abstract_inverted_index.clinical	32
abstract_inverted_index.compound	70, 149
abstract_inverted_index.integrin	16, 113
abstract_inverted_index.platelet	13, 87
abstract_inverted_index.potently	160
abstract_inverted_index.reported	65
abstract_inverted_index.slightly	173
abstract_inverted_index.thrombus	162
abstract_inverted_index.Mechanism	102
abstract_inverted_index.collagen,	138
abstract_inverted_index.decreased	161
abstract_inverted_index.effective	54
abstract_inverted_index.formation	163
abstract_inverted_index.indicated	104
abstract_inverted_index.inhibited	81, 107, 132
abstract_inverted_index.platelets	151
abstract_inverted_index.prolonged	174
abstract_inverted_index.spreading	152
abstract_inverted_index.thrombin,	139
abstract_inverted_index.together,	185
abstract_inverted_index.P-selectin	133
abstract_inverted_index.antagonist	194
abstract_inverted_index.collagen-,	83
abstract_inverted_index.derivative	69
abstract_inverted_index.expression	134
abstract_inverted_index.fibrinogen	111
abstract_inverted_index.manuscript	63
abstract_inverted_index.platelets.	146
abstract_inverted_index.researches	48
abstract_inverted_index.thrombin-,	84
abstract_inverted_index.thrombosis	168
abstract_inverted_index.tirofiban)	25
abstract_inverted_index.(abciximab,	22
abstract_inverted_index.aggregation	88
abstract_inverted_index.antagonists	21
abstract_inverted_index.development	51
abstract_inverted_index.fibrinogen.	156
abstract_inverted_index.immobilized	155
abstract_inverted_index.aggregation.	14
abstract_inverted_index.antiplatelet	57
abstract_inverted_index.naphthalenic	68
abstract_inverted_index.Additionally,	147
abstract_inverted_index.arteriovenous	166
abstract_inverted_index.eptifibatide,	23
abstract_inverted_index.respectively.	101
abstract_inverted_index.U46619-induced	86
abstract_inverted_index.Unfortunately,	34
abstract_inverted_index.antithrombotic	74, 202
abstract_inverted_index.dose-dependent	120
abstract_inverted_index.thrombocytopenia	43
cited_by_percentile_year.max	96
cited_by_percentile_year.min	89
corresponding_author_ids	https://openalex.org/A5014820919, https://openalex.org/A5100390293
countries_distinct_count	2
institutions_distinct_count	11
corresponding_institution_ids	https://openalex.org/I161716053
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.6600000262260437
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.72034188
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False