A naturalistic effectiveness study of maintenance therapies for the bipolar disorders Article Swipe
Michael J. Spoelma
,
Joanne Leidreiter
,
Adam Bayes
,
Artin Jebejian
,
Gordon Parker
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/acps.13646
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/acps.13646
Background Treatment decision‐making for individuals with bipolar disorder can be difficult. Recommendations from clinical practice guidelines can be affected by multiple methodological limitations, while pharmaco‐epidemiological data suggest great variety in prescription practices across regions. Given these inconsistencies, this study aimed to provide an alternative perspective on the effectiveness of common bipolar disorder maintenance treatments through considering naturalistic data. Methods A total of 246 individuals with bipolar disorder (84 bipolar I [BP‐I], 162 bipolar II [BP‐II]) were recruited through clinics and/or websites. All were euthymic and had trialled at least one mood stabiliser. They completed an online survey containing questions on demographics, clinical variables, symptomatology, and the effectiveness/side effect profiles of any mood stabilisers (MSTs) or atypical antipsychotics (AAPs) that they have taken. Results Lithium and lamotrigine were the most commonly prescribed MSTs and the most effective at mood stabilisation. Lithium and lamotrigine appeared marginally more effective for BP‐I and BP‐II respectively, however, only the latter difference was statistically significant. Furthermore, lamotrigine had the more favourable side effect profile. Amongst the AAPs, quetiapine and olanzapine were the most commonly prescribed, but they were negligibly superior to other AAPs. Conclusion This study clearly established a preference for lamotrigine in the maintenance treatment of BP‐II. While the literature consistently emphasises the primacy of lithium in bipolar disorder treatment, its side effect profile as observed in this study remains a concern. Future research considering moderators of treatment response and concomitant medications could help to identify further nuances to consider for treatment decision‐making.
Related Topics
Concepts
Lamotrigine
Bipolar disorder
Quetiapine
Mood stabilizer
Mood
Psychiatry
Treatment of bipolar disorder
Clinical psychology
Psychology
Olanzapine
Medicine
Mania
Schizophrenia (object-oriented programming)
Epilepsy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/acps.13646
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acps.13646
- OA Status
- hybrid
- Cited By
- 3
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389524147
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4389524147Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/acps.13646Digital Object Identifier
- Title
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A naturalistic effectiveness study of maintenance therapies for the bipolar disordersWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-10Full publication date if available
- Authors
-
Michael J. Spoelma, Joanne Leidreiter, Adam Bayes, Artin Jebejian, Gordon ParkerList of authors in order
- Landing page
-
https://doi.org/10.1111/acps.13646Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acps.13646Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acps.13646Direct OA link when available
- Concepts
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Lamotrigine, Bipolar disorder, Quetiapine, Mood stabilizer, Mood, Psychiatry, Treatment of bipolar disorder, Clinical psychology, Psychology, Olanzapine, Medicine, Mania, Schizophrenia (object-oriented programming), EpilepsyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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