A Noninvasive Approach to Optogenetics Using Focused Ultrasound Blood Brain Barrier Disruption for the Delivery of Radioluminescent Particles Article Swipe
Megan Rich
,
Eric Zhang
,
Ashley Dickey
,
Haley W. Jones
,
Kelli E Cannon
,
Yuriy Bandera
,
Stephen H. Foulger
,
Farah D. Lubin
,
Mark Bolding
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.08.20.248302
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.08.20.248302
Optogenetics, the genetic incorporation of light-sensitive proteins such as Channelrhodopsin-2 (ChR2) into target mammalian neurons, has enabled activation, silencing, and receptor subtype specific neuromodulation with high spatiotemporal resolution. However, the essential components of the ontogenetic system require invasive procedures with very few non-invasive alternatives preventing its use as a translational tool. The implantation of light emitting fibers deep within brain structures is both technically demanding and causes tissue scarring in target brain regions. To overcome these limitations, while maintaining the highly-tuned components of optogenetics we have developed a novel noninvasive alternative. Our approach replaces fibers with light-emitting radioluminescent particles (RLPs) that can be activated non-invasively with X-ray exposure. Here, we report successful noninvasive delivery of RLPs to target brain regions using MRI-guided focused ultrasound (FUS) blood brain barrier opening. In addition, FUS BBBO can be used to deliver viral vectors for light sensitive channel expression. Combined, these components can provide a completely non-invasive optogenetic system.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.08.20.248302
- https://www.biorxiv.org/content/biorxiv/early/2020/08/21/2020.08.20.248302.full.pdf
- OA Status
- green
- Cited By
- 5
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3080316889
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3080316889Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.08.20.248302Digital Object Identifier
- Title
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A Noninvasive Approach to Optogenetics Using Focused Ultrasound Blood Brain Barrier Disruption for the Delivery of Radioluminescent ParticlesWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-08-21Full publication date if available
- Authors
-
Megan Rich, Eric Zhang, Ashley Dickey, Haley W. Jones, Kelli E Cannon, Yuriy Bandera, Stephen H. Foulger, Farah D. Lubin, Mark BoldingList of authors in order
- Landing page
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https://doi.org/10.1101/2020.08.20.248302Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2020/08/21/2020.08.20.248302.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2020/08/21/2020.08.20.248302.full.pdfDirect OA link when available
- Concepts
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Optogenetics, Neuromodulation, Neuroscience, Blood–brain barrier, Focused ultrasound, Channelrhodopsin, Brain tissue, Computer science, Biology, Medicine, Ultrasound, Central nervous system, RadiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2022: 1, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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