A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus Article Swipe
Marcel Rühling
,
Fabio Schmelz
,
Kim Ulbrich
,
Julia Wolf
,
Maximilian Pfefferle
,
Adriana Moldovan
,
Nadine Knoch
,
Andreas Iwanowitsch
,
C. Oliver Kappe
,
Kerstin Paprotka
,
Christoph Arenz
,
Martin Fraunholz
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7554/elife.102810
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7554/elife.102810
Staphylococcus aureus is an opportunistic pathogen causing severe diseases. Recently, S. aureus was recognized as intracellular pathogen, whereby the intracellular niche promotes immune evasion and antibiotic resistance. Interaction of S. aureus with versatile host cell receptors was described previously, suggesting that internalization of the pathogen can occur via several pathways. It remains elusive whether the pathway of internalization can affect the intracellular fate of the bacteria. Here, we identified a mechanism governing cellular uptake of S. aureus which relies on lysosomal Ca2+, lysosomal exocytosis and occurs concurrently to other well-known entry pathways within the same host cell population. This internalization pathway is rapid and active within only few minutes after bacterial contact with host cells. Compared to slow bacterial internalization, the rapid pathway demonstrates altered phagosomal maturation as well as translocation of the pathogen to the host cytosol and ultimately results in different rates of intracellular bacterial replication and host cell death. We show that these alternative infection outcomes are caused by the mode of bacterial uptake.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.102810
- OA Status
- gold
- Cited By
- 1
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4404854532Canonical identifier for this work in OpenAlex
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https://doi.org/10.7554/elife.102810Digital Object Identifier
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A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureusWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-29Full publication date if available
- Authors
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Marcel Rühling, Fabio Schmelz, Kim Ulbrich, Julia Wolf, Maximilian Pfefferle, Adriana Moldovan, Nadine Knoch, Andreas Iwanowitsch, C. Oliver Kappe, Kerstin Paprotka, Christoph Arenz, Martin FraunholzList of authors in order
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https://doi.org/10.7554/elife.102810Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.7554/elife.102810Direct OA link when available
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Staphylococcus aureus, Intracellular, Microbiology, Host (biology), Chemistry, Cell biology, Biology, Bacteria, GeneticsTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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109Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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