A Patient with KL-6 Elevation with Anti-TNFα Who Could Receive Long-Term Use without Interstitial Pneumonia after Class Switch of Anti-TNFα Article Swipe
Takuya Masuda
,
Atsushi Yoshida
,
Fumiaki Ueno
,
Shintaro Hara
,
Haruaki Nabeta
,
Shotaro Umezawa
,
Mayuki Shirai
,
Yoshihide Morikawa
,
Toshio Morizane
,
Yutaka Endo
,
Toshifumi Hibi∥
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1159/000497778
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1159/000497778
A 40-year-old man with refractory ulcerative colitis (UC) was treated with tumor necrosis factor α inhibitor (anti-TNFα), infliximab. One month later, the chest computed tomography and laboratory test showed noninfectious interstitial lung disease (ILD) and elevation of serum Krebs von den Lungen-6 (KL-6). Fortunately, ILD disappeared after the discontinuation with anti-TNFα. Two and a half years after his first UC treatment, he was treated again with another anti-TNFα, adalimumab, for relapse and he had a second ILD. This course suggested anti-TNFα induced ILD. The characteristics of anti-TNFα-induced ILD in inflammatory bowel disease (IBD) are not well understood. We summarized and investigated the characteristics of such patients based on a literature review including 15 cases. It suggested that anti-TNFα-induced ILD in IBD might be rare and tends to have a better outcome compared with ILD in rheumatoid arthritis.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1159/000497778
- https://www.karger.com/Article/Pdf/497778
- OA Status
- gold
- Cited By
- 1
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2945648970
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2945648970Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1159/000497778Digital Object Identifier
- Title
-
A Patient with KL-6 Elevation with Anti-TNFα Who Could Receive Long-Term Use without Interstitial Pneumonia after Class Switch of Anti-TNFαWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-01-01Full publication date if available
- Authors
-
Takuya Masuda, Atsushi Yoshida, Fumiaki Ueno, Shintaro Hara, Haruaki Nabeta, Shotaro Umezawa, Mayuki Shirai, Yoshihide Morikawa, Toshio Morizane, Yutaka Endo, Toshifumi Hibi∥List of authors in order
- Landing page
-
https://doi.org/10.1159/000497778Publisher landing page
- PDF URL
-
https://www.karger.com/Article/Pdf/497778Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.karger.com/Article/Pdf/497778Direct OA link when available
- Concepts
-
Medicine, Adalimumab, Infliximab, Tumor necrosis factor alpha, Interstitial lung disease, Rheumatoid arthritis, Discontinuation, TNF inhibitor, Internal medicine, Inflammatory bowel disease, Gastroenterology, Refractory (planetary science), Ulcerative colitis, Lung, Disease, Astrobiology, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2019: 1Per-year citation counts (last 5 years)
- References (count)
-
34Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2945648970 |
|---|---|
| doi | https://doi.org/10.1159/000497778 |
| ids.doi | https://doi.org/10.1159/000497778 |
| ids.mag | 2945648970 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/31172011 |
| ids.openalex | https://openalex.org/W2945648970 |
| fwci | 0.20524598 |
| type | article |
| title | A Patient with KL-6 Elevation with Anti-TNFα Who Could Receive Long-Term Use without Interstitial Pneumonia after Class Switch of Anti-TNFα |
| biblio.issue | 1 |
| biblio.volume | 4 |
| biblio.last_page | 40 |
| biblio.first_page | 35 |
| topics[0].id | https://openalex.org/T10870 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis |
| topics[1].id | https://openalex.org/T11571 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9995999932289124 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2737 |
| topics[1].subfield.display_name | Physiology |
| topics[1].display_name | Sarcoidosis and Beryllium Toxicity Research |
| topics[2].id | https://openalex.org/T12328 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9993000030517578 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Autoimmune and Inflammatory Disorders |
| is_xpac | False |
| apc_list.value | 990 |
| apc_list.currency | USD |
| apc_list.value_usd | 990 |
| apc_paid.value | 990 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 990 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9100369215011597 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2780132546 |
| concepts[1].level | 3 |
| concepts[1].score | 0.8870702981948853 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q348260 |
| concepts[1].display_name | Adalimumab |
| concepts[2].id | https://openalex.org/C2777138892 |
| concepts[2].level | 3 |
| concepts[2].score | 0.8805474638938904 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q415264 |
| concepts[2].display_name | Infliximab |
| concepts[3].id | https://openalex.org/C17991360 |
| concepts[3].level | 2 |
| concepts[3].score | 0.8076115846633911 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q21173843 |
| concepts[3].display_name | Tumor necrosis factor alpha |
| concepts[4].id | https://openalex.org/C2777543607 |
| concepts[4].level | 3 |
| concepts[4].score | 0.7512222528457642 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1153419 |
| concepts[4].display_name | Interstitial lung disease |
| concepts[5].id | https://openalex.org/C2777575956 |
| concepts[5].level | 2 |
| concepts[5].score | 0.6897529363632202 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q187255 |
| concepts[5].display_name | Rheumatoid arthritis |
| concepts[6].id | https://openalex.org/C2778715236 |
| concepts[6].level | 2 |
| concepts[6].score | 0.6604881286621094 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q55622662 |
| concepts[6].display_name | Discontinuation |
| concepts[7].id | https://openalex.org/C2779722408 |
| concepts[7].level | 4 |
| concepts[7].score | 0.576958417892456 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1536078 |
| concepts[7].display_name | TNF inhibitor |
| concepts[8].id | https://openalex.org/C126322002 |
| concepts[8].level | 1 |
| concepts[8].score | 0.5491705536842346 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[8].display_name | Internal medicine |
| concepts[9].id | https://openalex.org/C2778260677 |
| concepts[9].level | 3 |
| concepts[9].score | 0.5200918912887573 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q917447 |
| concepts[9].display_name | Inflammatory bowel disease |
| concepts[10].id | https://openalex.org/C90924648 |
| concepts[10].level | 1 |
| concepts[10].score | 0.5192225575447083 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q120569 |
| concepts[10].display_name | Gastroenterology |
| concepts[11].id | https://openalex.org/C142424586 |
| concepts[11].level | 2 |
| concepts[11].score | 0.47757604718208313 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7307572 |
| concepts[11].display_name | Refractory (planetary science) |
| concepts[12].id | https://openalex.org/C2780479503 |
| concepts[12].level | 3 |
| concepts[12].score | 0.4726390242576599 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q1477 |
| concepts[12].display_name | Ulcerative colitis |
| concepts[13].id | https://openalex.org/C2777714996 |
| concepts[13].level | 2 |
| concepts[13].score | 0.32223308086395264 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7886 |
| concepts[13].display_name | Lung |
| concepts[14].id | https://openalex.org/C2779134260 |
| concepts[14].level | 2 |
| concepts[14].score | 0.25925949215888977 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[14].display_name | Disease |
| concepts[15].id | https://openalex.org/C87355193 |
| concepts[15].level | 1 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q411 |
| concepts[15].display_name | Astrobiology |
| concepts[16].id | https://openalex.org/C121332964 |
| concepts[16].level | 0 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q413 |
| concepts[16].display_name | Physics |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9100369215011597 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/adalimumab |
| keywords[1].score | 0.8870702981948853 |
| keywords[1].display_name | Adalimumab |
| keywords[2].id | https://openalex.org/keywords/infliximab |
| keywords[2].score | 0.8805474638938904 |
| keywords[2].display_name | Infliximab |
| keywords[3].id | https://openalex.org/keywords/tumor-necrosis-factor-alpha |
| keywords[3].score | 0.8076115846633911 |
| keywords[3].display_name | Tumor necrosis factor alpha |
| keywords[4].id | https://openalex.org/keywords/interstitial-lung-disease |
| keywords[4].score | 0.7512222528457642 |
| keywords[4].display_name | Interstitial lung disease |
| keywords[5].id | https://openalex.org/keywords/rheumatoid-arthritis |
| keywords[5].score | 0.6897529363632202 |
| keywords[5].display_name | Rheumatoid arthritis |
| keywords[6].id | https://openalex.org/keywords/discontinuation |
| keywords[6].score | 0.6604881286621094 |
| keywords[6].display_name | Discontinuation |
| keywords[7].id | https://openalex.org/keywords/tnf-inhibitor |
| keywords[7].score | 0.576958417892456 |
| keywords[7].display_name | TNF inhibitor |
| keywords[8].id | https://openalex.org/keywords/internal-medicine |
| keywords[8].score | 0.5491705536842346 |
| keywords[8].display_name | Internal medicine |
| keywords[9].id | https://openalex.org/keywords/inflammatory-bowel-disease |
| keywords[9].score | 0.5200918912887573 |
| keywords[9].display_name | Inflammatory bowel disease |
| keywords[10].id | https://openalex.org/keywords/gastroenterology |
| keywords[10].score | 0.5192225575447083 |
| keywords[10].display_name | Gastroenterology |
| keywords[11].id | https://openalex.org/keywords/refractory |
| keywords[11].score | 0.47757604718208313 |
| keywords[11].display_name | Refractory (planetary science) |
| keywords[12].id | https://openalex.org/keywords/ulcerative-colitis |
| keywords[12].score | 0.4726390242576599 |
| keywords[12].display_name | Ulcerative colitis |
| keywords[13].id | https://openalex.org/keywords/lung |
| keywords[13].score | 0.32223308086395264 |
| keywords[13].display_name | Lung |
| keywords[14].id | https://openalex.org/keywords/disease |
| keywords[14].score | 0.25925949215888977 |
| keywords[14].display_name | Disease |
| language | en |
| locations[0].id | doi:10.1159/000497778 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210175967 |
| locations[0].source.issn | 2296-9365, 2296-9403 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2296-9365 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Inflammatory Intestinal Diseases |
| locations[0].source.host_organization | https://openalex.org/P4310317820 |
| locations[0].source.host_organization_name | Karger Publishers |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310317820 |
| locations[0].license | |
| locations[0].pdf_url | https://www.karger.com/Article/Pdf/497778 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Inflammatory Intestinal Diseases |
| locations[0].landing_page_url | https://doi.org/10.1159/000497778 |
| locations[1].id | pmid:31172011 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Inflammatory intestinal diseases |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/31172011 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:6537466 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Inflamm Intest Dis |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6537466 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5022393845 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-3263-461X |
| authorships[0].author.display_name | Takuya Masuda |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[0].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[0].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[0].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Takuya Masuda |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[1].author.id | https://openalex.org/A5030259706 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5536-132X |
| authorships[1].author.display_name | Atsushi Yoshida |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[1].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[1].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[1].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Atsushi Yoshida |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[2].author.id | https://openalex.org/A5113494741 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Fumiaki Ueno |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[2].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[2].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[2].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Fumiaki Ueno |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[3].author.id | https://openalex.org/A5059336385 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-1429-5551 |
| authorships[3].author.display_name | Shintaro Hara |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[3].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[3].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[3].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Shintaro Hara |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[4].author.id | https://openalex.org/A5000917055 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Haruaki Nabeta |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[4].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[4].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[4].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Haruaki Nabeta |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[5].author.id | https://openalex.org/A5075587032 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-0251-3761 |
| authorships[5].author.display_name | Shotaro Umezawa |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[5].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[5].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[5].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Shotaro Umezawa |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[6].author.id | https://openalex.org/A5039128593 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Mayuki Shirai |
| authorships[6].countries | JP |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[6].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[6].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[6].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[6].institutions[0].country_code | JP |
| authorships[6].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Mayuki Shirai |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[7].author.id | https://openalex.org/A5061289601 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Yoshihide Morikawa |
| authorships[7].countries | JP |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[7].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[7].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[7].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[7].institutions[0].country_code | JP |
| authorships[7].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Yoshihide Morikawa |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[8].author.id | https://openalex.org/A5084639615 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Toshio Morizane |
| authorships[8].countries | JP |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[8].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[8].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[8].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[8].institutions[0].country_code | JP |
| authorships[8].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Toshio Morizane |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[9].author.id | https://openalex.org/A5041646818 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-7187-0124 |
| authorships[9].author.display_name | Yutaka Endo |
| authorships[9].countries | JP |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210148146 |
| authorships[9].affiliations[0].raw_affiliation_string | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[9].institutions[0].id | https://openalex.org/I4210148146 |
| authorships[9].institutions[0].ror | https://ror.org/05kgcmp18 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210132540, https://openalex.org/I4210148146 |
| authorships[9].institutions[0].country_code | JP |
| authorships[9].institutions[0].display_name | Gunma Chuo Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Yutaka Endo |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan |
| authorships[10].author.id | https://openalex.org/A5026205612 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-6256-1204 |
| authorships[10].author.display_name | Toshifumi Hibi∥ |
| authorships[10].countries | JP |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4210154200 |
| authorships[10].affiliations[0].raw_affiliation_string | Center for Advanced IBD Research and Treatment, Kitasato Institute Hospital, Tokyo, Japan |
| authorships[10].institutions[0].id | https://openalex.org/I4210154200 |
| authorships[10].institutions[0].ror | https://ror.org/05js82y61 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210154200 |
| authorships[10].institutions[0].country_code | JP |
| authorships[10].institutions[0].display_name | Kitasato Institute Hospital |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Toshifumi Hibi |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Center for Advanced IBD Research and Treatment, Kitasato Institute Hospital, Tokyo, Japan |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.karger.com/Article/Pdf/497778 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A Patient with KL-6 Elevation with Anti-TNFα Who Could Receive Long-Term Use without Interstitial Pneumonia after Class Switch of Anti-TNFα |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10870 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis |
| related_works | https://openalex.org/W2755604283, https://openalex.org/W1588288904, https://openalex.org/W3149869290, https://openalex.org/W2052175477, https://openalex.org/W2566490068, https://openalex.org/W2552612566, https://openalex.org/W3000540054, https://openalex.org/W2111533060, https://openalex.org/W4293536498, https://openalex.org/W1979155011 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2019 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1159/000497778 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210175967 |
| best_oa_location.source.issn | 2296-9365, 2296-9403 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2296-9365 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Inflammatory Intestinal Diseases |
| best_oa_location.source.host_organization | https://openalex.org/P4310317820 |
| best_oa_location.source.host_organization_name | Karger Publishers |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310317820 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.karger.com/Article/Pdf/497778 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Inflammatory Intestinal Diseases |
| best_oa_location.landing_page_url | https://doi.org/10.1159/000497778 |
| primary_location.id | doi:10.1159/000497778 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210175967 |
| primary_location.source.issn | 2296-9365, 2296-9403 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2296-9365 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Inflammatory Intestinal Diseases |
| primary_location.source.host_organization | https://openalex.org/P4310317820 |
| primary_location.source.host_organization_name | Karger Publishers |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310317820 |
| primary_location.license | |
| primary_location.pdf_url | https://www.karger.com/Article/Pdf/497778 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Inflammatory Intestinal Diseases |
| primary_location.landing_page_url | https://doi.org/10.1159/000497778 |
| publication_date | 2019-01-01 |
| publication_year | 2019 |
| referenced_works | https://openalex.org/W2009025779, https://openalex.org/W2077950073, https://openalex.org/W2077659453, https://openalex.org/W2613128349, https://openalex.org/W1846061753, https://openalex.org/W2263402151, https://openalex.org/W2133460035, https://openalex.org/W1595345234, https://openalex.org/W2072301382, https://openalex.org/W2298905268, https://openalex.org/W2337898304, https://openalex.org/W2162799563, https://openalex.org/W2039180673, https://openalex.org/W2171297959, https://openalex.org/W2152015928, https://openalex.org/W1998480796, https://openalex.org/W2319818535, https://openalex.org/W2190558971, https://openalex.org/W2126003842, https://openalex.org/W2025809313, https://openalex.org/W1608343961, https://openalex.org/W2108581097, https://openalex.org/W1976954029, https://openalex.org/W2163911658, https://openalex.org/W2602122563, https://openalex.org/W2023433230, https://openalex.org/W2119133165, https://openalex.org/W4234613487, https://openalex.org/W4230555018, https://openalex.org/W4249000573, https://openalex.org/W2011040773, https://openalex.org/W2049695294, https://openalex.org/W2411900093, https://openalex.org/W1992818134 |
| referenced_works_count | 34 |
| abstract_inverted_index.A | 0 |
| abstract_inverted_index.a | 53, 74, 108, 128 |
| abstract_inverted_index.15 | 112 |
| abstract_inverted_index.It | 114 |
| abstract_inverted_index.UC | 59 |
| abstract_inverted_index.We | 97 |
| abstract_inverted_index.be | 122 |
| abstract_inverted_index.he | 61, 72 |
| abstract_inverted_index.in | 88, 119, 134 |
| abstract_inverted_index.of | 36, 85, 103 |
| abstract_inverted_index.on | 107 |
| abstract_inverted_index.to | 126 |
| abstract_inverted_index.α | 14 |
| abstract_inverted_index.IBD | 120 |
| abstract_inverted_index.ILD | 44, 87, 118, 133 |
| abstract_inverted_index.One | 18 |
| abstract_inverted_index.The | 83 |
| abstract_inverted_index.Two | 51 |
| abstract_inverted_index.and | 25, 34, 52, 71, 99, 124 |
| abstract_inverted_index.are | 93 |
| abstract_inverted_index.den | 40 |
| abstract_inverted_index.for | 69 |
| abstract_inverted_index.had | 73 |
| abstract_inverted_index.his | 57 |
| abstract_inverted_index.man | 2 |
| abstract_inverted_index.not | 94 |
| abstract_inverted_index.the | 21, 47, 101 |
| abstract_inverted_index.von | 39 |
| abstract_inverted_index.was | 8, 62 |
| abstract_inverted_index.(UC) | 7 |
| abstract_inverted_index.ILD. | 76, 82 |
| abstract_inverted_index.This | 77 |
| abstract_inverted_index.half | 54 |
| abstract_inverted_index.have | 127 |
| abstract_inverted_index.lung | 31 |
| abstract_inverted_index.rare | 123 |
| abstract_inverted_index.such | 104 |
| abstract_inverted_index.test | 27 |
| abstract_inverted_index.that | 116 |
| abstract_inverted_index.well | 95 |
| abstract_inverted_index.with | 3, 10, 49, 65, 132 |
| abstract_inverted_index.(IBD) | 92 |
| abstract_inverted_index.(ILD) | 33 |
| abstract_inverted_index.Krebs | 38 |
| abstract_inverted_index.after | 46, 56 |
| abstract_inverted_index.again | 64 |
| abstract_inverted_index.based | 106 |
| abstract_inverted_index.bowel | 90 |
| abstract_inverted_index.chest | 22 |
| abstract_inverted_index.first | 58 |
| abstract_inverted_index.might | 121 |
| abstract_inverted_index.month | 19 |
| abstract_inverted_index.serum | 37 |
| abstract_inverted_index.tends | 125 |
| abstract_inverted_index.tumor | 11 |
| abstract_inverted_index.years | 55 |
| abstract_inverted_index.better | 129 |
| abstract_inverted_index.cases. | 113 |
| abstract_inverted_index.course | 78 |
| abstract_inverted_index.factor | 13 |
| abstract_inverted_index.later, | 20 |
| abstract_inverted_index.review | 110 |
| abstract_inverted_index.second | 75 |
| abstract_inverted_index.showed | 28 |
| abstract_inverted_index.(KL-6). | 42 |
| abstract_inverted_index.another | 66 |
| abstract_inverted_index.colitis | 6 |
| abstract_inverted_index.disease | 32, 91 |
| abstract_inverted_index.induced | 81 |
| abstract_inverted_index.outcome | 130 |
| abstract_inverted_index.relapse | 70 |
| abstract_inverted_index.treated | 9, 63 |
| abstract_inverted_index.Lungen-6 | 41 |
| abstract_inverted_index.compared | 131 |
| abstract_inverted_index.computed | 23 |
| abstract_inverted_index.necrosis | 12 |
| abstract_inverted_index.patients | 105 |
| abstract_inverted_index.elevation | 35 |
| abstract_inverted_index.including | 111 |
| abstract_inverted_index.inhibitor | 15 |
| abstract_inverted_index.suggested | 79, 115 |
| abstract_inverted_index.anti-TNFα | 80 |
| abstract_inverted_index.arthritis. | 136 |
| abstract_inverted_index.laboratory | 26 |
| abstract_inverted_index.literature | 109 |
| abstract_inverted_index.refractory | 4 |
| abstract_inverted_index.rheumatoid | 135 |
| abstract_inverted_index.summarized | 98 |
| abstract_inverted_index.tomography | 24 |
| abstract_inverted_index.treatment, | 60 |
| abstract_inverted_index.ulcerative | 5 |
| abstract_inverted_index.40-year-old | 1 |
| abstract_inverted_index.adalimumab, | 68 |
| abstract_inverted_index.anti-TNFα, | 67 |
| abstract_inverted_index.anti-TNFα. | 50 |
| abstract_inverted_index.disappeared | 45 |
| abstract_inverted_index.infliximab. | 17 |
| abstract_inverted_index.understood. | 96 |
| abstract_inverted_index.Fortunately, | 43 |
| abstract_inverted_index.inflammatory | 89 |
| abstract_inverted_index.interstitial | 30 |
| abstract_inverted_index.investigated | 100 |
| abstract_inverted_index.(anti-TNFα), | 16 |
| abstract_inverted_index.noninfectious | 29 |
| abstract_inverted_index.characteristics | 84, 102 |
| abstract_inverted_index.discontinuation | 48 |
| abstract_inverted_index.anti-TNFα-induced | 86, 117 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.55462216 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |