A personalized osteoarthritic joint-on-a-chip as a screening platform for biological treatments Article Swipe
Dalila Petta
,
Daniele D’Arrigo
,
Shima Salehi
,
Giuseppe Talò
,
Lorenzo Bonetti
,
Marco Vanoni
,
Luca Deabate
,
Luigi De Nardo
,
Gabriele Dubini
,
Christian Candrian
,
Matteo Moretti
,
Silvia Lopa
,
Chiara Arrigoni
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.mtbio.2024.101072
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.mtbio.2024.101072
Osteoarthritis (OA) is a highly disabling pathology, characterized by synovial inflammation and cartilage degeneration. Orthobiologics have shown promising results in OA treatment thanks to their ability to influence articular cells and modulate the inflammatory OA environment. Considering their complex mechanism of action, the development of reliable and relevant joint models appears as crucial to select the best orthobiologics for each patient. The aim of this study was to establish a microfluidic OA model to test therapies in a personalized human setting. The joint-on-a-chip model included cartilage and synovial compartments, containing hydrogel-embedded chondrocytes and synovial fibroblasts, separated by a channel for synovial fluid. For the cartilage compartment, a Hyaluronic Acid-based matrix was selected to preserve chondrocyte phenotype. Adding OA synovial fluid induced the production of inflammatory cytokines and degradative enzymes, generating an OA microenvironment. Personalized models were generated using patient-matched cells and synovial fluid to test the efficacy of mesenchymal stem cells on OA signatures. The patient-specific models allowed monitoring changes induced by cell injection, highlighting different individual responses to the treatment. Altogether, these results support the use of this joint-on-a-chip model as a prognostic tool to screen the patient-specific efficacy of orthobiologics.
Related Topics
Concepts
Osteoarthritis
Synovial fluid
Cartilage
Hyaluronic acid
Chondrocyte
Medicine
Mesenchymal stem cell
Synovial joint
Compartment (ship)
Inflammation
Pathology
Articular cartilage
Cancer research
Bioinformatics
Immunology
Biology
Anatomy
Geology
Oceanography
Alternative medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.mtbio.2024.101072
- OA Status
- gold
- Cited By
- 8
- References
- 59
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396661023
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396661023Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.mtbio.2024.101072Digital Object Identifier
- Title
-
A personalized osteoarthritic joint-on-a-chip as a screening platform for biological treatmentsWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-05-06Full publication date if available
- Authors
-
Dalila Petta, Daniele D’Arrigo, Shima Salehi, Giuseppe Talò, Lorenzo Bonetti, Marco Vanoni, Luca Deabate, Luigi De Nardo, Gabriele Dubini, Christian Candrian, Matteo Moretti, Silvia Lopa, Chiara ArrigoniList of authors in order
- Landing page
-
https://doi.org/10.1016/j.mtbio.2024.101072Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.mtbio.2024.101072Direct OA link when available
- Concepts
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Osteoarthritis, Synovial fluid, Cartilage, Hyaluronic acid, Chondrocyte, Medicine, Mesenchymal stem cell, Synovial joint, Compartment (ship), Inflammation, Pathology, Articular cartilage, Cancer research, Bioinformatics, Immunology, Biology, Anatomy, Geology, Oceanography, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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59Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W4211067786, https://openalex.org/W2074916651, https://openalex.org/W2017869529, https://openalex.org/W3092910273, https://openalex.org/W2889382187, https://openalex.org/W2097351928, https://openalex.org/W4282934737, https://openalex.org/W2342436095, https://openalex.org/W2940129814, https://openalex.org/W3169179040, https://openalex.org/W2947666887, https://openalex.org/W1992193707, https://openalex.org/W2120232825, https://openalex.org/W2584503597, https://openalex.org/W2074691820, https://openalex.org/W2967981201, https://openalex.org/W6628336588, https://openalex.org/W4290098980, https://openalex.org/W2590465402, https://openalex.org/W6786220939, https://openalex.org/W1999277351, https://openalex.org/W2053808972, https://openalex.org/W1239091656, https://openalex.org/W1970656189, https://openalex.org/W1496525613, https://openalex.org/W2889071254, https://openalex.org/W2317607677, https://openalex.org/W2910518458, https://openalex.org/W2022069856, https://openalex.org/W3042574300, https://openalex.org/W2070206697, https://openalex.org/W6766785840, https://openalex.org/W2920832988, https://openalex.org/W6748280891, https://openalex.org/W2094209140, https://openalex.org/W1940768227, https://openalex.org/W2041636732, https://openalex.org/W6796092648, https://openalex.org/W2010404343, https://openalex.org/W2192566214, https://openalex.org/W1984947474, https://openalex.org/W2018258390, https://openalex.org/W3196359455, https://openalex.org/W2116044476, https://openalex.org/W2555192490, https://openalex.org/W1980174191, https://openalex.org/W2091076719, https://openalex.org/W2004290723, https://openalex.org/W1882351611, https://openalex.org/W1966130397, https://openalex.org/W1586814698, https://openalex.org/W4391749603, https://openalex.org/W3128044437, https://openalex.org/W2969591772, https://openalex.org/W4323074998, https://openalex.org/W3107908934, https://openalex.org/W2788309342, https://openalex.org/W2899860405, https://openalex.org/W3165691852 |
| referenced_works_count | 59 |
| abstract_inverted_index.a | 3, 69, 77, 97, 106, 182 |
| abstract_inverted_index.OA | 20, 34, 71, 117, 131, 152 |
| abstract_inverted_index.an | 130 |
| abstract_inverted_index.as | 51, 181 |
| abstract_inverted_index.by | 8, 96, 161 |
| abstract_inverted_index.in | 19, 76 |
| abstract_inverted_index.is | 2 |
| abstract_inverted_index.of | 40, 44, 63, 123, 147, 177, 190 |
| abstract_inverted_index.on | 151 |
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| abstract_inverted_index.For | 102 |
| abstract_inverted_index.The | 61, 81, 154 |
| abstract_inverted_index.aim | 62 |
| abstract_inverted_index.and | 11, 30, 46, 86, 92, 126, 140 |
| abstract_inverted_index.for | 58, 99 |
| abstract_inverted_index.the | 32, 42, 55, 103, 121, 145, 169, 175, 187 |
| abstract_inverted_index.use | 176 |
| abstract_inverted_index.was | 66, 110 |
| abstract_inverted_index.(OA) | 1 |
| abstract_inverted_index.best | 56 |
| abstract_inverted_index.cell | 162 |
| abstract_inverted_index.each | 59 |
| abstract_inverted_index.have | 15 |
| abstract_inverted_index.stem | 149 |
| abstract_inverted_index.test | 74, 144 |
| abstract_inverted_index.this | 64, 178 |
| abstract_inverted_index.tool | 184 |
| abstract_inverted_index.were | 135 |
| abstract_inverted_index.cells | 29, 139, 150 |
| abstract_inverted_index.fluid | 119, 142 |
| abstract_inverted_index.human | 79 |
| abstract_inverted_index.joint | 48 |
| abstract_inverted_index.model | 72, 83, 180 |
| abstract_inverted_index.shown | 16 |
| abstract_inverted_index.study | 65 |
| abstract_inverted_index.their | 24, 37 |
| abstract_inverted_index.these | 172 |
| abstract_inverted_index.using | 137 |
| abstract_inverted_index.Adding | 116 |
| abstract_inverted_index.fluid. | 101 |
| abstract_inverted_index.highly | 4 |
| abstract_inverted_index.matrix | 109 |
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| abstract_inverted_index.screen | 186 |
| abstract_inverted_index.select | 54 |
| abstract_inverted_index.thanks | 22 |
| abstract_inverted_index.ability | 25 |
| abstract_inverted_index.action, | 41 |
| abstract_inverted_index.allowed | 157 |
| abstract_inverted_index.appears | 50 |
| abstract_inverted_index.changes | 159 |
| abstract_inverted_index.channel | 98 |
| abstract_inverted_index.complex | 38 |
| abstract_inverted_index.crucial | 52 |
| abstract_inverted_index.induced | 120, 160 |
| abstract_inverted_index.results | 18, 173 |
| abstract_inverted_index.support | 174 |
| abstract_inverted_index.efficacy | 146, 189 |
| abstract_inverted_index.enzymes, | 128 |
| abstract_inverted_index.included | 84 |
| abstract_inverted_index.modulate | 31 |
| abstract_inverted_index.patient. | 60 |
| abstract_inverted_index.preserve | 113 |
| abstract_inverted_index.relevant | 47 |
| abstract_inverted_index.reliable | 45 |
| abstract_inverted_index.selected | 111 |
| abstract_inverted_index.setting. | 80 |
| abstract_inverted_index.synovial | 9, 87, 93, 100, 118, 141 |
| abstract_inverted_index.articular | 28 |
| abstract_inverted_index.cartilage | 12, 85, 104 |
| abstract_inverted_index.cytokines | 125 |
| abstract_inverted_index.different | 165 |
| abstract_inverted_index.disabling | 5 |
| abstract_inverted_index.establish | 68 |
| abstract_inverted_index.generated | 136 |
| abstract_inverted_index.influence | 27 |
| abstract_inverted_index.mechanism | 39 |
| abstract_inverted_index.promising | 17 |
| abstract_inverted_index.responses | 167 |
| abstract_inverted_index.separated | 95 |
| abstract_inverted_index.therapies | 75 |
| abstract_inverted_index.treatment | 21 |
| abstract_inverted_index.Acid-based | 108 |
| abstract_inverted_index.Hyaluronic | 107 |
| abstract_inverted_index.containing | 89 |
| abstract_inverted_index.generating | 129 |
| abstract_inverted_index.individual | 166 |
| abstract_inverted_index.injection, | 163 |
| abstract_inverted_index.monitoring | 158 |
| abstract_inverted_index.pathology, | 6 |
| abstract_inverted_index.phenotype. | 115 |
| abstract_inverted_index.production | 122 |
| abstract_inverted_index.prognostic | 183 |
| abstract_inverted_index.treatment. | 170 |
| abstract_inverted_index.Altogether, | 171 |
| abstract_inverted_index.Considering | 36 |
| abstract_inverted_index.chondrocyte | 114 |
| abstract_inverted_index.degradative | 127 |
| abstract_inverted_index.development | 43 |
| abstract_inverted_index.mesenchymal | 148 |
| abstract_inverted_index.signatures. | 153 |
| abstract_inverted_index.Personalized | 133 |
| abstract_inverted_index.chondrocytes | 91 |
| abstract_inverted_index.compartment, | 105 |
| abstract_inverted_index.environment. | 35 |
| abstract_inverted_index.fibroblasts, | 94 |
| abstract_inverted_index.highlighting | 164 |
| abstract_inverted_index.inflammation | 10 |
| abstract_inverted_index.inflammatory | 33, 124 |
| abstract_inverted_index.microfluidic | 70 |
| abstract_inverted_index.personalized | 78 |
| abstract_inverted_index.characterized | 7 |
| abstract_inverted_index.compartments, | 88 |
| abstract_inverted_index.degeneration. | 13 |
| abstract_inverted_index.Orthobiologics | 14 |
| abstract_inverted_index.Osteoarthritis | 0 |
| abstract_inverted_index.orthobiologics | 57 |
| abstract_inverted_index.joint-on-a-chip | 82, 179 |
| abstract_inverted_index.orthobiologics. | 191 |
| abstract_inverted_index.patient-matched | 138 |
| abstract_inverted_index.patient-specific | 155, 188 |
| abstract_inverted_index.hydrogel-embedded | 90 |
| abstract_inverted_index.microenvironment. | 132 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5080949471 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I4210113215 |
| citation_normalized_percentile.value | 0.95592377 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |