A phase I study of AZD8186 in combination with docetaxel in patients with PTEN-mutated or PIK3CB-mutated advanced solid tumors Article Swipe

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Alison M. Schram , Naoko Takebe , Anna Chen , Qin Zhou , Alexia Iasonos , Jeffrey L. Silber , M.E. Reynolds , Samsinah Hussain , Mihail Gavriliuc , Lillian M. Smyth , D. H. Garrison , Ecaterina E. Dumbrava ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1016/j.esmoop.2025.105569

The combination of AZD8186 and docetaxel was generally well tolerated, with the exception of neutropenia, which was effectively managed with the use of growth factor. Limited clinical activity was observed.

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.esmoop.2025.105569
OA Status: gold
References: 49
Related Works: 10
OpenAlex ID: https://openalex.org/W4414118663

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OpenAlex ID: https://openalex.org/W4414118663

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DOI: https://doi.org/10.1016/j.esmoop.2025.105569

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Title: A phase I study of AZD8186 in combination with docetaxel in patients with PTEN-mutated or PIK3CB-mutated advanced solid tumors

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-09-01

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Authors: Alison M. Schram, Naoko Takebe, Anna Chen, Qin Zhou, Alexia Iasonos, Jeffrey L. Silber, M.E. Reynolds, Samsinah Hussain, Mihail Gavriliuc, Lillian M. Smyth, D. H. Garrison, Ecaterina E. Dumbrava

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Landing page: https://doi.org/10.1016/j.esmoop.2025.105569

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OA status: gold

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OA URL: https://doi.org/10.1016/j.esmoop.2025.105569

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Cited by: 0

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References (count): 49

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Related works (count): 10

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