A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years Article Swipe
Lorenzo Tonetti
,
Federico Camilli
,
Sara Giovagnoli
,
Vincenzo Natale
,
Alessandra Lugaresi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/clockssleep3030023
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/clockssleep3030023
Early multiple sclerosis (MS) predictive markers of disease activity/prognosis have been proposed but are not universally accepted. Aim of this pilot prospective study is to verify whether a peculiar hyperactivity, observed at baseline (T0) in early relapsing-remitting (RR) MS patients, could represent a further prognostic marker. Here we report results collected at T0 and at a 24-month follow-up (T1). Eighteen RRMS patients (11 females, median Expanded Disability Status Scale-EDSS score 1.25, range EDSS score 0–2) were monitored at T0 (mean age 32.33 ± 7.51) and T1 (median EDSS score 1.5, range EDSS score 0–2.5). Patients were grouped into two groups: responders (R, 14 patients) and non-responders (NR, 4 patients) to treatment at T1. Each patient wore an actigraph for one week to record the 24-h motor activity pattern. At T0, NR presented significantly lower motor activity than R between around 9:00 and 13:00. At T1, NR were characterized by significantly lower motor activity than R between around 12:00 and 17:00. Overall, these data suggest that through the 24-h motor activity pattern, we can fairly segregate at T0 patients who will show a therapeutic failure, possibly related to a more active disease, at T1. These patients are characterized by a reduced morning level of motor activation. Further studies on larger populations are needed to confirm these preliminary findings.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/clockssleep3030023
- https://www.mdpi.com/2624-5175/3/3/23/pdf?version=1625194993
- OA Status
- gold
- References
- 23
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3176439942
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3176439942Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/clockssleep3030023Digital Object Identifier
- Title
-
A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 YearsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-28Full publication date if available
- Authors
-
Lorenzo Tonetti, Federico Camilli, Sara Giovagnoli, Vincenzo Natale, Alessandra LugaresiList of authors in order
- Landing page
-
https://doi.org/10.3390/clockssleep3030023Publisher landing page
- PDF URL
-
https://www.mdpi.com/2624-5175/3/3/23/pdf?version=1625194993Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2624-5175/3/3/23/pdf?version=1625194993Direct OA link when available
- Concepts
-
Multiple sclerosis, Expanded Disability Status Scale, Medicine, Internal medicine, Motor activity, Physical therapy, Physical medicine and rehabilitation, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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23Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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