A Pilot Study on Viral Load in Stool Samples of Patients with COVID-19 Suffering from Diarrhea Article Swipe
Yutaro Akiyama
,
Noriko Kinoshita
,
Kenji Sadamasu
,
Mami Nagashima
,
Isao Yoshida
,
Yusaku Kusaba
,
Tetsuya Suzuki
,
Maki Nagashima
,
Masahiro Ishikane
,
Jin Takasaki
,
Kazuhisa Yoshimura
,
Norio Ohmagari
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.7883/yoken.jjid.2021.018
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.7883/yoken.jjid.2021.018
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be detected in the stool samples of patients with coronavirus disease 2019 (COVID-19), and this virus can be transmitted via the oral-fecal route. However, there are only few reports on the viral load in the stool samples. In this pilot study, we aimed to evaluate the clinical characteristics and viral load of SARS-CoV-2 in the stool samples of 13 patients with confirmed COVID-19 using pepper mild mottle virus as a control, which has been proposed as a potential marker of human feces contamination in the environmental water bodies. SARS-CoV-2 RNA was detected in the stool samples of four patients (31%), and among them, three exhibited symptoms of diarrhea. One patient who suffered from long-term diarrhea (22 days) exhibited highest level of viral RNA in the stool sample (8.28 log10 copies/g). However, we could not harvest SARS-CoV-2 from the stool sample of any patient, even after culturing with VeroE6/TMPRESS2 cells for four weeks. Our results suggest that SARS-CoV-2 RNA can be detected in the stool samples of patients with COVID-19 suffering from diarrhea. However, further studies elucidating the relationship between SARS-CoV-2 viral load in the stool samples and symptoms of diarrhea in large cohorts and upon adjusting other causative factors and virus infectivity are still warranted.
Related Topics
Concepts
Diarrhea
Feces
Viral load
Coronavirus
Medicine
Infectivity
Virus
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Virology
Coronavirus disease 2019 (COVID-19)
Internal medicine
Gastroenterology
Disease
Microbiology
Biology
Infectious disease (medical specialty)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7883/yoken.jjid.2021.018
- https://www.jstage.jst.go.jp/article/yoken/75/1/75_JJID.2021.018/_pdf
- OA Status
- diamond
- Cited By
- 13
- References
- 14
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3165654099
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3165654099Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7883/yoken.jjid.2021.018Digital Object Identifier
- Title
-
A Pilot Study on Viral Load in Stool Samples of Patients with COVID-19 Suffering from DiarrheaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-30Full publication date if available
- Authors
-
Yutaro Akiyama, Noriko Kinoshita, Kenji Sadamasu, Mami Nagashima, Isao Yoshida, Yusaku Kusaba, Tetsuya Suzuki, Maki Nagashima, Masahiro Ishikane, Jin Takasaki, Kazuhisa Yoshimura, Norio OhmagariList of authors in order
- Landing page
-
https://doi.org/10.7883/yoken.jjid.2021.018Publisher landing page
- PDF URL
-
https://www.jstage.jst.go.jp/article/yoken/75/1/75_JJID.2021.018/_pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.jstage.jst.go.jp/article/yoken/75/1/75_JJID.2021.018/_pdfDirect OA link when available
- Concepts
-
Diarrhea, Feces, Viral load, Coronavirus, Medicine, Infectivity, Virus, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Virology, Coronavirus disease 2019 (COVID-19), Internal medicine, Gastroenterology, Disease, Microbiology, Biology, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
-
13Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 3, 2023: 5, 2022: 4, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
14Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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