A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.1038/s41523-025-00720-3
Residual Cancer Burden (RCB) after neoadjuvant chemotherapy (NAC) is validated to predict event-free survival (EFS) in breast cancer but has not been studied for invasive lobular carcinoma (ILC). We studied patient-level data from a pooled cohort across 12 institutions. Associations between RCB index, class, and EFS were assessed in ILC and non-ILC with mixed effect Cox models and multivariable analyses. Recursive partitioning was used in an exploratory model to stratify prognosis by RCB components. Of 5106 patients, the diagnosis was ILC in 216 and non-ILC in 4890. Increased RCB index was associated with worse EFS in both ILC and non-ILC ( p = 0.002 and p < 0.001, respectively) and remained prognostic when stratified by receptor subtype and adjusted for age, grade, T category, and nodal status. Recursive partitioning demonstrated residual invasive cancer cellularity as most prognostic in ILC. These results underscore the utility of RCB for evaluating NAC response in those with ILC.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41523-025-00720-3
- OA Status
- gold
- Cited By
- 4
- References
- 39
- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4407538000Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41523-025-00720-3Digital Object Identifier
- Title
-
A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancerWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-13Full publication date if available
- Authors
-
Rita A. Mukhtar, Soumya Gottipati, Christina Yau, Sara López‐Tarruella, Helena Earl, Larry Hayward, Louise Hiller, Marie Osdoit, Marieke van der Noordaa, Diane De Croze, Anne‐Sophie Hamy, Marick Laé, Fabien Reyal, Gabe S. Sonke, Tessa G. Steenbruggen, Maartje van Seijen, Jelle Wesseling, Miguel Martín, María del Monte‐Millán, Judy C. Boughey, Matthew P. Goetz, Tanya L. Hoskin, Vicente Valero, Stephen B. Edge, Jean Abraham, Thomas John, Carlos Caldas, Janet Dunn, Elena Provenzano, Stephen‐John Sammut, Jeremy Thomas, A Graham, Peter Hall, Lorna Mackintosh, Fang Fan, Andrew K. Godwin, Kelsey Schwensen, Priyanka Sharma, Angela DeMichele, Kimberly Cole, Lajos Pusztai, Mi‐Ok Kim, Laura van ’t Veer, David Cameron, Laura J. Esserman, W. Fraser SymmansList of authors in order
- Landing page
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https://doi.org/10.1038/s41523-025-00720-3Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1038/s41523-025-00720-3Direct OA link when available
- Concepts
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Invasive lobular carcinoma, Breast cancer, Medicine, Oncology, Internal medicine, Proportional hazards model, Cancer, Cohort, Invasive ductal carcinomaTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
- References (count)
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39Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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