A practical approach to panel design, validation, and interpretation for the evaluation of T ‐cell neoplasms by flow cytometry
Article Swipe
Jean Oak
,
Felipe Magalhaes Furtado
,
Katherine Devitt
,
Pedro Horna
,
Jonathan R. Fromm
,
Lianqun Qiu
,
Andrea Illingworth
,
Jolene Cardinali
,
Wolfgang Kern
,
Ahmad Al‐Attar
,
Min Shi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/cyto.b.22258
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/cyto.b.22258
The diagnosis of T‐cell neoplasms remains one of the most challenging areas in hematopathology due to the immunophenotypic heterogeneity and subtle aberrancies often present in these entities. This “Best Practice” manuscript provides a practical framework for laboratories to design, validate, and interpret immunophenotyping studies of immature and mature T‐cell neoplasms. We outline the utility of key antigens in the screening and classification of T‐cell lymphomas/leukemia including TRBC1 and TRBC2. Analytical strategies using the “difference from normal” method and template‐based gating are discussed, along with validation considerations aligned with CLSI H62 guidelines. By integrating these principles into laboratory workflows, this manuscript aims to standardize and improve the assessment of T‐cell neoplasms across diverse clinical settings.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cyto.b.22258
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.22258
- OA Status
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- Cited By
- 2
- References
- 76
- OpenAlex ID
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- OpenAlex ID
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https://openalex.org/W4415406799Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/cyto.b.22258Digital Object Identifier
- Title
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A practical approach to panel design, validation, and interpretation for the evaluation of
T ‐cell neoplasms by flow cytometryWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-10-22Full publication date if available
- Authors
-
Jean Oak, Felipe Magalhaes Furtado, Katherine Devitt, Pedro Horna, Jonathan R. Fromm, Lianqun Qiu, Andrea Illingworth, Jolene Cardinali, Wolfgang Kern, Ahmad Al‐Attar, Min ShiList of authors in order
- Landing page
-
https://doi.org/10.1002/cyto.b.22258Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.22258Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.22258Direct OA link when available
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
- References (count)
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76Number of works referenced by this work
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