A Quantitative Particle Identification (QPID) spectral autoradiography system Article Swipe
Stephen Adler
,
Noriko Sato
,
Kwamena E. Baidoo
,
Frank I. Lin
,
Woong Hee Lee
,
Colleen Olkowski
,
Freddy E. Escorcia
,
Peter L. Choyke
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s44172-025-00426-1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s44172-025-00426-1
Autoradiography is used to study the distribution and binding of radioisotope tagged ligands in tissue at microscale among other applications. The technology has evolved since its inception when it used analogue film exposure techniques with the introduction of digital imaging systems sensitive to ionizing radiation. We report on the development of our Quantitative Particle Identification spectral autoradiography system (QPID), which is based on the Timepix3 sensor and a gamma detecting scintillation crystal. This autoradiography system leverages the ionizing radiation detection features of the Timepix3 to measure the energy deposition from charged particles from radioisotopes with a time resolution of 7.7 ns full width at half max (FWHM), generating spectral or activity autoradiography images. The QPID includes a scintillation crystal used to record gamma emissions coincident with the Timepix3 ionization events with a time resolution of 24.2 ns FWHM. The QPID can separate tracks between α and ß particles, select specific ranges of deposited energies or select on the presence of coincident gamma emissions within a selected energy range when generating images. The QPID has a 10% linearity response up to 700 Bq for 223Ra and 2.5 kBq for 18 F radioisotopes. Using α and ß+ particle identification filters, separate images of 223 RaCl 2 and Na 18 F activity distributions were generated from a bone sample infused with the two radioligands together. This unique capability can open the door to the study of targeted radiotherapies which use theranostic α and ß+ imaging agents by measuring their relative pharmacokinetic properties.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s44172-025-00426-1
- https://www.nature.com/articles/s44172-025-00426-1.pdf
- OA Status
- diamond
- Cited By
- 2
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410412136
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410412136Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s44172-025-00426-1Digital Object Identifier
- Title
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A Quantitative Particle Identification (QPID) spectral autoradiography systemWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-15Full publication date if available
- Authors
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Stephen Adler, Noriko Sato, Kwamena E. Baidoo, Frank I. Lin, Woong Hee Lee, Colleen Olkowski, Freddy E. Escorcia, Peter L. ChoykeList of authors in order
- Landing page
-
https://doi.org/10.1038/s44172-025-00426-1Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s44172-025-00426-1.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.nature.com/articles/s44172-025-00426-1.pdfDirect OA link when available
- Concepts
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Full width at half maximum, Scintillation, Ionizing radiation, Physics, Radiation, Range (aeronautics), Materials science, Optics, Nuclear physics, Irradiation, Detector, Composite materialTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
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19Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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