A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosis Article Swipe
Lora Clawson
,
Merit Cudkowicz
,
Lisa S. Krivickas
,
Benjamin Rix Brooks
,
Mohammed Sanjak
,
Peggy Allred
,
Nazem Atassi
,
Amy Swartz
,
Gabrielle Steinhorn
,
Alpa Uchil
,
Kristen M. Riley
,
Hong Yu
,
David Schoenfeld
,
Nicholas J. Maragakis
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.5657221
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.5657221
Objective: Evaluate the safety and tolerability of resistance and endurance exercise in ALS participants as measured by their ability to complete this six-month study. Methods: Participants were randomized to Resistance, Endurance, or Stretching/Range of Motion (SROM the exercise regimen prescribed for most ALS patients) exercises. All exercises were performed at home with an individualized regimen designed by a physical therapist trained in ALS management. Primary outcome measures were tolerability of the exercises at 24 weeks defined by 50% of participants completing at least 50% of the prescribed exercise regimen. Secondary outcome measures included the ALSFRS-R, pulmonary FVC, and other measures of ALS function. Results: At 12 and 24 weeks, all three exercise regimens were tolerated according to our pre-specified criteria. Compliance to the prescribed exercise regimen was the highest in the resistance and SROM arms of the study. All three forms of exercise were considered safe as there were no differences in the rates of disease progression among groups. There were no differences in the secondary outcome measures and feasibility for evaluating these measures was successful. In a post-hoc analysis, there was a trend towards fewer falls in the Resistance and Endurance groups. Conclusions: This study demonstrates that SROM, resistance, and endurance exercise are all safe to be performed with the specified regimen without any worsening of outcomes as related to ALS function. All three forms of exercise were tolerated with resistance and SROM exercises showing the highest compliance over the 24 week-period.
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Metadata
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- OA Status
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All OpenAlex metadata
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https://openalex.org/W4394294032Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.6084/m9.figshare.5657221Digital Object Identifier
- Title
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A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosisWork title
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datasetOpenAlex work type
- Language
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enPrimary language
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2023Year of publication
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2023-01-01Full publication date if available
- Authors
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Lora Clawson, Merit Cudkowicz, Lisa S. Krivickas, Benjamin Rix Brooks, Mohammed Sanjak, Peggy Allred, Nazem Atassi, Amy Swartz, Gabrielle Steinhorn, Alpa Uchil, Kristen M. Riley, Hong Yu, David Schoenfeld, Nicholas J. MaragakisList of authors in order
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https://doi.org/10.6084/m9.figshare.5657221Publisher landing page
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.6084/m9.figshare.5657221Direct OA link when available
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Amyotrophic lateral sclerosis, Resistance training, Physical medicine and rehabilitation, Medicine, Randomized controlled trial, Physical therapy, Internal medicine, DiseaseTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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