A randomized, double-blind, placebo-controlled study of histone deacetylase type 6 inhibition for the treatment of painful diabetic peripheral neuropathy Article Swipe
David Michelson
,
William W. Chin
,
Robert H. Dworkin
,
Roy Freeman
,
David N. Herrmann
,
Ralph Mazitschek
,
Rodica Pop‐Busui
,
Aziz Shaibani
,
James J. Vornov
,
Melissa Jones
,
Matthew Jarpe
,
Brittany Hader
,
Theresa Viera
,
Michelle Hylan
,
Tim Kachmar
,
Simon Jones
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1097/pr9.0000000000001114
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1097/pr9.0000000000001114
Introduction: Current treatments for painful diabetic peripheral neuropathy (DPN) are insufficiently effective for many individuals and do not treat nonpain signs and symptoms. The enzyme histone deacetylase type 6 (HDAC6) may play a role in the pathophysiology of painful DPN, and inhibition of HDAC6 has been proposed as a potential treatment. Objectives: To assess the efficacy and safety of the novel HDAC6 inhibitor ricolinostat for the treatment of painful diabetic peripheral neuropathy. Methods: We conducted a 12-week randomized, double-blind, placebo-controlled phase 2 study of the efficacy of ricolinostat, a novel selective HDAC6 inhibitor, in 282 individuals with painful DPN. The primary outcome was the change in the patient-reported pain using a daily diary, and a key secondary outcome was severity of nonpain neuropathic signs using the Utah Early Neuropathy Scale (UENS) score. Results: At the 12-week assessment, changes in average daily pain and UENS scores were not different between the ricolinostat and placebo groups. Conclusion: These results do not support the use of the HDAC6 inhibitor ricolinostat as a treatment for neuropathic pain in DPN for periods up to 12 weeks.
Related Topics
Concepts
Medicine
Peripheral neuropathy
Placebo
Neuropathic pain
HDAC6
Placebo-controlled study
Diabetic neuropathy
Internal medicine
Randomized controlled trial
Double blind
Anesthesia
Histone deacetylase
Diabetes mellitus
Endocrinology
Histone
Pathology
Biochemistry
Chemistry
Gene
Alternative medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/pr9.0000000000001114
- OA Status
- gold
- Cited By
- 5
- References
- 6
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388035397
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388035397Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/pr9.0000000000001114Digital Object Identifier
- Title
-
A randomized, double-blind, placebo-controlled study of histone deacetylase type 6 inhibition for the treatment of painful diabetic peripheral neuropathyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-26Full publication date if available
- Authors
-
David Michelson, William W. Chin, Robert H. Dworkin, Roy Freeman, David N. Herrmann, Ralph Mazitschek, Rodica Pop‐Busui, Aziz Shaibani, James J. Vornov, Melissa Jones, Matthew Jarpe, Brittany Hader, Theresa Viera, Michelle Hylan, Tim Kachmar, Simon JonesList of authors in order
- Landing page
-
https://doi.org/10.1097/pr9.0000000000001114Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1097/pr9.0000000000001114Direct OA link when available
- Concepts
-
Medicine, Peripheral neuropathy, Placebo, Neuropathic pain, HDAC6, Placebo-controlled study, Diabetic neuropathy, Internal medicine, Randomized controlled trial, Double blind, Anesthesia, Histone deacetylase, Diabetes mellitus, Endocrinology, Histone, Pathology, Biochemistry, Chemistry, Gene, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
6Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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