A Rare Case of Pseudohypercalcemia Associated with Multiple Myeloma. Article Swipe

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Chiharu Mishima , Kimikazu Yakushijin , Hidenori Fukuoka , Ruri Takahashi , Yuri Okazoe , Miki Joyce , Sakuya Matsumoto , Rina Sakai , Yumiko Inui , Keiji Kurata , Hironobu Minami ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.24546/0100495981

We report a rare case of pseudohypercalcemia associated with multiple myeloma in a 77-year-old woman. Despite elevated albumin-corrected calcium levels (12.6 mg/dL), ionized calcium levels remained normal (1.25 mmol/L). Differential diagnoses excluded common causes of hypercalcemia, and the findings suggested calcium binding to negatively charged immunoglobulins and confirmed pseudohypercalcemia due to IgG-type myeloma. Treatment with isatuximab plus dexamethasone normalized albumin-corrected calcium levels as IgG levels decreased. This report highlights the importance of recognizing pseudohypercalcemia to prevent misdiagnosis of true hypercalcemia due to myeloma. Measuring ionized calcium levels is crucial for accurate diagnosis when hypercalcemia is suspected without corresponding clinical symptoms.

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Multiple myeloma Rare events Medicine Internal medicine Mathematics Statistics

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Type: article
Language: en
Landing Page: https://pubmed.ncbi.nlm.nih.gov/40610015
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4412047224

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DOI: https://doi.org/10.24546/0100495981

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Title: A Rare Case of Pseudohypercalcemia Associated with Multiple Myeloma.

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-05-30

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Authors: Chiharu Mishima, Kimikazu Yakushijin, Hidenori Fukuoka, Ruri Takahashi, Yuri Okazoe, Miki Joyce, Sakuya Matsumoto, Rina Sakai, Yumiko Inui, Keiji Kurata, Hironobu Minami

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Landing page: https://pubmed.ncbi.nlm.nih.gov/40610015

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OA status: gold

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OA URL: https://doi.org/10.24546/0100495981

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Concepts: Multiple myeloma, Rare events, Medicine, Internal medicine, Mathematics, Statistics

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Related works (count): 10

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