Cell Communication and Signaling • Vol 22 • No 1
A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
February 2024 • Brian G. Poll, Kirby T. Leo, Venky Deshpande, Nipun U. Jayatissa, Trairak Pisitkun, Euijung Park, Chin‐Rang Yang, Viswanathan Raghuram, Mark A. Knepp…
Abstract Background Protein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes, and is mediated by over 520 protein kinases in humans and other mammals. Identification of the protein kinases responsible for phosphorylation events is key to understanding signaling pathways. Unbiased phosphoproteomics experiments have generated a wealth of data that can be used to identify protein kinase targets and their preferred substrate sequences. Met…