A Retrospective Analysis for Different Routes of Administration in Mice-Percutaneous Retro-Orbital, Jugular Catheter, Tail Vein and Femoral Cut Down Injections Article Swipe
Priyanka Prathipati
,
Cristian Rodriguez‐Aguayo
,
Brian Walton
,
Anil K. Sood
,
Jamieson Greaver
,
Christopher F. Janssen
,
Gabriel López-Berestein
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4236/jbm.2020.89011
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4236/jbm.2020.89011
Liposomes effectively transport fatty proteins to targeted tissues. Laboratory experiments use multiple methods to administer liposomes, but comparison of these methods is not available. In this retrospective study, we characterized and compared four intravenous administration routes (tail vein, jugular catheter, femoral vein and percutaneous retro-orbital injections) in murine models. ApoE-/- mice were used to compare administration routes. Results indicate that the jugular catheter route delivered the highest amount of liposomes to tissues due to longer period of injections compared to other routes; however, this route failed to remain patent for 8/10 animals. Delivery via tail vein, femoral vein and percutaneous retro-orbital injections resulted in similar accumulation in the organs. When including technical difficulty and expense, percutaneous retro-orbital injections of liposomes are the most convenient and efficacious approach.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4236/jbm.2020.89011
- http://www.scirp.org/journal/PaperDownload.aspx?paperID=102903
- OA Status
- diamond
- Cited By
- 6
- References
- 13
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3087465595
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3087465595Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4236/jbm.2020.89011Digital Object Identifier
- Title
-
A Retrospective Analysis for Different Routes of Administration in Mice-Percutaneous Retro-Orbital, Jugular Catheter, Tail Vein and Femoral Cut Down InjectionsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-01Full publication date if available
- Authors
-
Priyanka Prathipati, Cristian Rodriguez‐Aguayo, Brian Walton, Anil K. Sood, Jamieson Greaver, Christopher F. Janssen, Gabriel López-BeresteinList of authors in order
- Landing page
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https://doi.org/10.4236/jbm.2020.89011Publisher landing page
- PDF URL
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https://www.scirp.org/journal/PaperDownload.aspx?paperID=102903Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://www.scirp.org/journal/PaperDownload.aspx?paperID=102903Direct OA link when available
- Concepts
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Medicine, Percutaneous, Femoral vein, Tail vein, Jugular vein, Catheter, Liposome, Vein, Internal jugular vein, Surgery, In vivo, Chemistry, Biology, Biochemistry, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 3, 2022: 1Per-year citation counts (last 5 years)
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13Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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