A review of 99mTc-sestamibi SPECT/CT for renal oncocytomas: A modified diagnostic algorithm Article Swipe
Mitchell P. Wilson
,
Prayash Katlariwala
,
Jonathan Abele
,
Gavin Low
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.5582/irdr.2022.01027
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.5582/irdr.2022.01027
99mTc-sestamibi SPECT/CT is a promising nuclear medicine imaging investigation for benign renal lesions such as renal oncocytomas. The purpose of this article is to i) review the current literature on 99mTc-sestamibi SPECT/CT, ii) to review to current application of 99mTc-sestamibi SPECT/CT for indeterminate renal lesion imaging, and iii) to discuss present limitations and areas for future research. The literature has been reviewed up to April 2022 for articles relating to the application of 99mTc-sestamibi SPECT/CT for benign renal lesions including a recently published systematic review and meta-analysis performed by the authors. One study evaluating 99mTc-sestamibi SPECT alone and five studies evaluating 99mTc-sestamibi SPECT/CT have been performed to date. 99mTc-sestamibi SPECT/CT demonstrates high sensitivity and specificity for detecting benign renal lesions, particularly renal oncocytomas. 99mTc-sestamibi SPECT/CT demonstrates near-perfect specificity for benign and low-grade renal lesions. The optimal quantified threshold ratio for tumor-to-background renal parenchyma radiotracer uptake for a positive result is > 0.6. In this article, we propose a modified diagnostic algorithm for small enhancing renal masses measuring 1-4 cm in which suspected benign lesions after conventional imaging are considered for 99mTc-sestamibi SPECT-CT. In this algorithm, positive studies can be monitored with active surveillance rather than requiring invasive biopsy and/or targeted therapy.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.5582/irdr.2022.01027
- https://www.jstage.jst.go.jp/article/irdr/11/2/11_2022.01027/_pdf
- OA Status
- diamond
- Cited By
- 7
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4282961412
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4282961412Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5582/irdr.2022.01027Digital Object Identifier
- Title
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A review of 99mTc-sestamibi SPECT/CT for renal oncocytomas: A modified diagnostic algorithmWork title
- Type
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reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-05-05Full publication date if available
- Authors
-
Mitchell P. Wilson, Prayash Katlariwala, Jonathan Abele, Gavin LowList of authors in order
- Landing page
-
https://doi.org/10.5582/irdr.2022.01027Publisher landing page
- PDF URL
-
https://www.jstage.jst.go.jp/article/irdr/11/2/11_2022.01027/_pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
diamondOpen access status per OpenAlex
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https://www.jstage.jst.go.jp/article/irdr/11/2/11_2022.01027/_pdfDirect OA link when available
- Concepts
-
Medicine, Technetium Tc 99m Sestamibi, Radiology, Nuclear medicine, Spect imaging, ScintigraphyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
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29Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
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