A role for miR-132 in learned safety Article Swipe
Marianne Ronovsky
,
Alice Zambon
,
Ana Cicvaric
,
Vincent Boehm
,
Bastian Hoesel
,
Bernhard Moser
,
Jiaye Yang
,
Johannes A. Schmid
,
Wulf Haubensak
,
Francisco J. Monje
,
Daniela D. Pollak
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-018-37054-z
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-018-37054-z
Learned safety is a fear inhibitory mechanism, which regulates fear responses, promotes episodes of safety and generates positive affective states. Despite its potential as experimental model for several psychiatric illnesses, including post-traumatic stress disorder and depression, the molecular mechanisms of learned safety remain poorly understood, We here investigated the molecular mediators of learned safety, focusing on the characterization of miRNA expression in the basolateral amygdala (BLA). Comparing levels of 22 miRNAs in learned safety and learned fear trained mice, six safety-related miRNAs, including three members of the miR-132/-212 family, were identified. A gain-of-function approach based upon in-vivo transfection of a specific miRNA mimic, and miR-132/212 knock-out mice as loss-of-function tool were used in order to determine the relevance of miR-132 for learned safety at the behavioral and the neuronal functional levels. Using a designated bioinformatic approach, PTEN and GAT1 were identified as potential novel miR-132 target genes and further experimentally validated. We here firstly provide evidence for a regulation of amygdala miRNA expression in learned safety and propose miR-132 as signature molecule to be considered in future preclinical and translational approaches testing the transdiagnostic relevance of learned safety as intermediate phenotype in fear and stress-related disorders.
Related Topics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-018-37054-z
- https://www.nature.com/articles/s41598-018-37054-z.pdf
- OA Status
- gold
- Cited By
- 21
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2924088715
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2924088715Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-018-37054-zDigital Object Identifier
- Title
-
A role for miR-132 in learned safetyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-01-24Full publication date if available
- Authors
-
Marianne Ronovsky, Alice Zambon, Ana Cicvaric, Vincent Boehm, Bastian Hoesel, Bernhard Moser, Jiaye Yang, Johannes A. Schmid, Wulf Haubensak, Francisco J. Monje, Daniela D. PollakList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-018-37054-zPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-018-37054-z.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41598-018-37054-z.pdfDirect OA link when available
- Concepts
-
Computational biology, Computer science, Bioinformatics, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
21Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 7, 2022: 2, 2021: 5, 2020: 3Per-year citation counts (last 5 years)
- References (count)
-
62Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2924088715 |
|---|---|
| doi | https://doi.org/10.1038/s41598-018-37054-z |
| ids.doi | https://doi.org/10.1038/s41598-018-37054-z |
| ids.mag | 2924088715 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/30679653 |
| ids.openalex | https://openalex.org/W2924088715 |
| fwci | 1.1729358 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D016475 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | 3T3 Cells |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000818 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Animals |
| mesh[2].qualifier_ui | Q000502 |
| mesh[2].descriptor_ui | D066272 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | physiology |
| mesh[2].descriptor_name | Basolateral Nuclear Complex |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D003213 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Conditioning, Psychological |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D005239 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Fear |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D005786 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Gene Expression Regulation |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D008297 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Male |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D051379 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Mice |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D008810 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Mice, Inbred C57BL |
| mesh[9].qualifier_ui | Q000235 |
| mesh[9].descriptor_ui | D035683 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | genetics |
| mesh[9].descriptor_name | MicroRNAs |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D016475 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | 3T3 Cells |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D000818 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Animals |
| mesh[12].qualifier_ui | Q000502 |
| mesh[12].descriptor_ui | D066272 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | physiology |
| mesh[12].descriptor_name | Basolateral Nuclear Complex |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D003213 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Conditioning, Psychological |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D005239 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Fear |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D005786 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Gene Expression Regulation |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D008297 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Male |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D051379 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Mice |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D008810 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Mice, Inbred C57BL |
| mesh[19].qualifier_ui | Q000235 |
| mesh[19].descriptor_ui | D035683 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | genetics |
| mesh[19].descriptor_name | MicroRNAs |
| type | article |
| title | A role for miR-132 in learned safety |
| biblio.issue | 1 |
| biblio.volume | 9 |
| biblio.last_page | 528 |
| biblio.first_page | 528 |
| grants[0].funder | https://openalex.org/F4320321181 |
| grants[0].award_id | P 31004 |
| grants[0].funder_display_name | Austrian Science Fund |
| grants[1].funder | https://openalex.org/F4320321181 |
| grants[1].award_id | P 31004 |
| grants[1].funder_display_name | Austrian Science Fund |
| grants[2].funder | https://openalex.org/F4320334678 |
| grants[2].award_id | 311701 |
| grants[2].funder_display_name | European Research Council |
| topics[0].id | https://openalex.org/T10062 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9937000274658203 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1306 |
| topics[0].subfield.display_name | Cancer Research |
| topics[0].display_name | MicroRNA in disease regulation |
| topics[1].id | https://openalex.org/T11307 |
| topics[1].field.id | https://openalex.org/fields/17 |
| topics[1].field.display_name | Computer Science |
| topics[1].score | 0.9424999952316284 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1702 |
| topics[1].subfield.display_name | Artificial Intelligence |
| topics[1].display_name | Domain Adaptation and Few-Shot Learning |
| topics[2].id | https://openalex.org/T12676 |
| topics[2].field.id | https://openalex.org/fields/17 |
| topics[2].field.display_name | Computer Science |
| topics[2].score | 0.934499979019165 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1702 |
| topics[2].subfield.display_name | Artificial Intelligence |
| topics[2].display_name | Machine Learning and ELM |
| funders[0].id | https://openalex.org/F4320321181 |
| funders[0].ror | https://ror.org/013tf3c58 |
| funders[0].display_name | Austrian Science Fund |
| funders[1].id | https://openalex.org/F4320334678 |
| funders[1].ror | https://ror.org/0472cxd90 |
| funders[1].display_name | European Research Council |
| is_xpac | False |
| apc_list.value | 1890 |
| apc_list.currency | EUR |
| apc_list.value_usd | 2190 |
| apc_paid.value | 1644 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 1773 |
| concepts[0].id | https://openalex.org/C70721500 |
| concepts[0].level | 1 |
| concepts[0].score | 0.4334598481655121 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[0].display_name | Computational biology |
| concepts[1].id | https://openalex.org/C41008148 |
| concepts[1].level | 0 |
| concepts[1].score | 0.3888077139854431 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[1].display_name | Computer science |
| concepts[2].id | https://openalex.org/C60644358 |
| concepts[2].level | 1 |
| concepts[2].score | 0.342009037733078 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[2].display_name | Bioinformatics |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.2753062844276428 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| keywords[0].id | https://openalex.org/keywords/computational-biology |
| keywords[0].score | 0.4334598481655121 |
| keywords[0].display_name | Computational biology |
| keywords[1].id | https://openalex.org/keywords/computer-science |
| keywords[1].score | 0.3888077139854431 |
| keywords[1].display_name | Computer science |
| keywords[2].id | https://openalex.org/keywords/bioinformatics |
| keywords[2].score | 0.342009037733078 |
| keywords[2].display_name | Bioinformatics |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.2753062844276428 |
| keywords[3].display_name | Biology |
| language | en |
| locations[0].id | doi:10.1038/s41598-018-37054-z |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S196734849 |
| locations[0].source.issn | 2045-2322 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2045-2322 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Scientific Reports |
| locations[0].source.host_organization | https://openalex.org/P4310319908 |
| locations[0].source.host_organization_name | Nature Portfolio |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319908 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.nature.com/articles/s41598-018-37054-z.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Scientific Reports |
| locations[0].landing_page_url | https://doi.org/10.1038/s41598-018-37054-z |
| locations[1].id | pmid:30679653 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Scientific reports |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/30679653 |
| locations[2].id | pmh:oai:europepmc.org:5330323 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | http://europepmc.org/pmc/articles/PMC6346013 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:6346013 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Sci Rep |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6346013 |
| locations[4].id | pmh:oai:doaj.org/article:1b9fedf1fe1c44859cadaac290733032 |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].source.host_organization_lineage | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019) |
| locations[4].landing_page_url | https://doaj.org/article/1b9fedf1fe1c44859cadaac290733032 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5111558372 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Marianne Ronovsky |
| authorships[0].countries | AT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[0].institutions[0].id | https://openalex.org/I76134821 |
| authorships[0].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[0].institutions[0].country_code | AT |
| authorships[0].institutions[0].display_name | Medical University of Vienna |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Marianne Ronovsky |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[1].author.id | https://openalex.org/A5020763630 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Alice Zambon |
| authorships[1].countries | AT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[1].institutions[0].id | https://openalex.org/I76134821 |
| authorships[1].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[1].institutions[0].country_code | AT |
| authorships[1].institutions[0].display_name | Medical University of Vienna |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Alice Zambon |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[2].author.id | https://openalex.org/A5019182247 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-3560-4491 |
| authorships[2].author.display_name | Ana Cicvaric |
| authorships[2].countries | AT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[2].institutions[0].id | https://openalex.org/I76134821 |
| authorships[2].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[2].institutions[0].country_code | AT |
| authorships[2].institutions[0].display_name | Medical University of Vienna |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ana Cicvaric |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[3].author.id | https://openalex.org/A5014000455 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-3113-9497 |
| authorships[3].author.display_name | Vincent Boehm |
| authorships[3].countries | AT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I195525897 |
| authorships[3].affiliations[0].raw_affiliation_string | Research Institute of Molecular Pathology, Vienna, Austria |
| authorships[3].institutions[0].id | https://openalex.org/I195525897 |
| authorships[3].institutions[0].ror | https://ror.org/02c5jsm26 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I195525897 |
| authorships[3].institutions[0].country_code | AT |
| authorships[3].institutions[0].display_name | Research Institute of Molecular Pathology |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Vincent Boehm |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Research Institute of Molecular Pathology, Vienna, Austria |
| authorships[4].author.id | https://openalex.org/A5054480020 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-7025-081X |
| authorships[4].author.display_name | Bastian Hoesel |
| authorships[4].countries | AT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[4].institutions[0].id | https://openalex.org/I76134821 |
| authorships[4].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[4].institutions[0].country_code | AT |
| authorships[4].institutions[0].display_name | Medical University of Vienna |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Bastian Hoesel |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[5].author.id | https://openalex.org/A5112351710 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Bernhard Moser |
| authorships[5].countries | AT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[5].institutions[0].id | https://openalex.org/I76134821 |
| authorships[5].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[5].institutions[0].country_code | AT |
| authorships[5].institutions[0].display_name | Medical University of Vienna |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Bernhard A. Moser |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[6].author.id | https://openalex.org/A5066999017 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Jiaye Yang |
| authorships[6].countries | AT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[6].institutions[0].id | https://openalex.org/I76134821 |
| authorships[6].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[6].institutions[0].country_code | AT |
| authorships[6].institutions[0].display_name | Medical University of Vienna |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Jiaye Yang |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[7].author.id | https://openalex.org/A5054762808 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-6586-3507 |
| authorships[7].author.display_name | Johannes A. Schmid |
| authorships[7].countries | AT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[7].institutions[0].id | https://openalex.org/I76134821 |
| authorships[7].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[7].institutions[0].country_code | AT |
| authorships[7].institutions[0].display_name | Medical University of Vienna |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Johannes A. Schmid |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[8].author.id | https://openalex.org/A5087716020 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-2034-9184 |
| authorships[8].author.display_name | Wulf Haubensak |
| authorships[8].countries | AT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I195525897 |
| authorships[8].affiliations[0].raw_affiliation_string | Research Institute of Molecular Pathology, Vienna, Austria |
| authorships[8].institutions[0].id | https://openalex.org/I195525897 |
| authorships[8].institutions[0].ror | https://ror.org/02c5jsm26 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I195525897 |
| authorships[8].institutions[0].country_code | AT |
| authorships[8].institutions[0].display_name | Research Institute of Molecular Pathology |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Wulf E. Haubensak |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Research Institute of Molecular Pathology, Vienna, Austria |
| authorships[9].author.id | https://openalex.org/A5056830056 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-6496-0030 |
| authorships[9].author.display_name | Francisco J. Monje |
| authorships[9].countries | AT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[9].institutions[0].id | https://openalex.org/I76134821 |
| authorships[9].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[9].institutions[0].country_code | AT |
| authorships[9].institutions[0].display_name | Medical University of Vienna |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Francisco J. Monje |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[10].author.id | https://openalex.org/A5048450444 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9584-6257 |
| authorships[10].author.display_name | Daniela D. Pollak |
| authorships[10].countries | AT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| authorships[10].institutions[0].id | https://openalex.org/I76134821 |
| authorships[10].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[10].institutions[0].country_code | AT |
| authorships[10].institutions[0].display_name | Medical University of Vienna |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Daniela D. Pollak |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.nature.com/articles/s41598-018-37054-z.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A role for miR-132 in learned safety |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10062 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9937000274658203 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1306 |
| primary_topic.subfield.display_name | Cancer Research |
| primary_topic.display_name | MicroRNA in disease regulation |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2899084033, https://openalex.org/W2748952813, https://openalex.org/W2390279801, https://openalex.org/W4391913857, https://openalex.org/W2358668433, https://openalex.org/W4396701345, https://openalex.org/W2376932109, https://openalex.org/W2001405890, https://openalex.org/W4396696052 |
| cited_by_count | 21 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 7 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 2 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 5 |
| counts_by_year[4].year | 2020 |
| counts_by_year[4].cited_by_count | 3 |
| counts_by_year[5].year | 2019 |
| counts_by_year[5].cited_by_count | 3 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1038/s41598-018-37054-z |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S196734849 |
| best_oa_location.source.issn | 2045-2322 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2045-2322 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Scientific Reports |
| best_oa_location.source.host_organization | https://openalex.org/P4310319908 |
| best_oa_location.source.host_organization_name | Nature Portfolio |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319908 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.nature.com/articles/s41598-018-37054-z.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Scientific Reports |
| best_oa_location.landing_page_url | https://doi.org/10.1038/s41598-018-37054-z |
| primary_location.id | doi:10.1038/s41598-018-37054-z |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S196734849 |
| primary_location.source.issn | 2045-2322 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2045-2322 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Scientific Reports |
| primary_location.source.host_organization | https://openalex.org/P4310319908 |
| primary_location.source.host_organization_name | Nature Portfolio |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319908 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.nature.com/articles/s41598-018-37054-z.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Scientific Reports |
| primary_location.landing_page_url | https://doi.org/10.1038/s41598-018-37054-z |
| publication_date | 2019-01-24 |
| publication_year | 2019 |
| referenced_works | https://openalex.org/W2047702351, https://openalex.org/W2103704610, https://openalex.org/W1977988769, https://openalex.org/W2012159547, https://openalex.org/W1986764547, https://openalex.org/W2019181653, https://openalex.org/W2049738669, https://openalex.org/W2024030860, https://openalex.org/W2034288991, https://openalex.org/W2109505983, https://openalex.org/W1992687523, https://openalex.org/W2015431173, https://openalex.org/W2035341085, https://openalex.org/W2065608765, https://openalex.org/W1970685138, https://openalex.org/W2563398409, https://openalex.org/W2014812461, https://openalex.org/W2130779240, https://openalex.org/W2089233932, https://openalex.org/W1981044491, https://openalex.org/W2035063219, https://openalex.org/W2126799774, https://openalex.org/W2027166786, https://openalex.org/W2557286791, https://openalex.org/W2474895768, https://openalex.org/W2605681290, https://openalex.org/W2144511694, https://openalex.org/W2055772777, https://openalex.org/W2154241726, https://openalex.org/W2060515857, https://openalex.org/W2092113020, https://openalex.org/W2202656845, https://openalex.org/W2164684873, https://openalex.org/W2802438942, https://openalex.org/W2059357290, https://openalex.org/W2059222949, https://openalex.org/W2006831423, https://openalex.org/W2120474278, https://openalex.org/W2318838494, https://openalex.org/W2506498303, https://openalex.org/W2044686824, https://openalex.org/W1977502547, https://openalex.org/W1977028183, https://openalex.org/W2239556028, https://openalex.org/W2007058306, https://openalex.org/W2115476694, https://openalex.org/W1588326306, https://openalex.org/W2162983737, https://openalex.org/W2137380770, https://openalex.org/W1984124345, https://openalex.org/W1995621192, https://openalex.org/W1979405589, https://openalex.org/W1991660337, https://openalex.org/W2088875650, https://openalex.org/W2075522824, https://openalex.org/W2001863509, https://openalex.org/W2002686613, https://openalex.org/W2047271769, https://openalex.org/W3145571634, https://openalex.org/W2523206485, https://openalex.org/W1959821071, https://openalex.org/W2081408258 |
| referenced_works_count | 62 |
| abstract_inverted_index.A | 92 |
| abstract_inverted_index.a | 4, 100, 133, 158 |
| abstract_inverted_index.22 | 70 |
| abstract_inverted_index.We | 46, 152 |
| abstract_inverted_index.as | 24, 108, 142, 170, 189 |
| abstract_inverted_index.at | 124 |
| abstract_inverted_index.be | 174 |
| abstract_inverted_index.in | 62, 72, 113, 164, 176, 192 |
| abstract_inverted_index.is | 3 |
| abstract_inverted_index.of | 14, 40, 52, 59, 69, 86, 99, 119, 160, 186 |
| abstract_inverted_index.on | 56 |
| abstract_inverted_index.to | 115, 173 |
| abstract_inverted_index.and | 16, 35, 75, 104, 127, 138, 148, 167, 179, 194 |
| abstract_inverted_index.for | 27, 121, 157 |
| abstract_inverted_index.its | 22 |
| abstract_inverted_index.six | 80 |
| abstract_inverted_index.the | 37, 49, 57, 63, 87, 117, 125, 128, 183 |
| abstract_inverted_index.GAT1 | 139 |
| abstract_inverted_index.PTEN | 137 |
| abstract_inverted_index.fear | 5, 10, 77, 193 |
| abstract_inverted_index.here | 47, 153 |
| abstract_inverted_index.mice | 107 |
| abstract_inverted_index.tool | 110 |
| abstract_inverted_index.upon | 96 |
| abstract_inverted_index.used | 112 |
| abstract_inverted_index.were | 90, 111, 140 |
| abstract_inverted_index.Using | 132 |
| abstract_inverted_index.based | 95 |
| abstract_inverted_index.genes | 147 |
| abstract_inverted_index.miRNA | 60, 102, 162 |
| abstract_inverted_index.mice, | 79 |
| abstract_inverted_index.model | 26 |
| abstract_inverted_index.novel | 144 |
| abstract_inverted_index.order | 114 |
| abstract_inverted_index.three | 84 |
| abstract_inverted_index.which | 8 |
| abstract_inverted_index.(BLA). | 66 |
| abstract_inverted_index.future | 177 |
| abstract_inverted_index.levels | 68 |
| abstract_inverted_index.miRNAs | 71 |
| abstract_inverted_index.mimic, | 103 |
| abstract_inverted_index.poorly | 44 |
| abstract_inverted_index.remain | 43 |
| abstract_inverted_index.safety | 2, 15, 42, 74, 123, 166, 188 |
| abstract_inverted_index.stress | 33 |
| abstract_inverted_index.target | 146 |
| abstract_inverted_index.Despite | 21 |
| abstract_inverted_index.Learned | 1 |
| abstract_inverted_index.family, | 89 |
| abstract_inverted_index.firstly | 154 |
| abstract_inverted_index.further | 149 |
| abstract_inverted_index.in-vivo | 97 |
| abstract_inverted_index.learned | 41, 53, 73, 76, 122, 165, 187 |
| abstract_inverted_index.levels. | 131 |
| abstract_inverted_index.members | 85 |
| abstract_inverted_index.miR-132 | 120, 145, 169 |
| abstract_inverted_index.miRNAs, | 82 |
| abstract_inverted_index.propose | 168 |
| abstract_inverted_index.provide | 155 |
| abstract_inverted_index.safety, | 54 |
| abstract_inverted_index.several | 28 |
| abstract_inverted_index.states. | 20 |
| abstract_inverted_index.testing | 182 |
| abstract_inverted_index.trained | 78 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.amygdala | 65, 161 |
| abstract_inverted_index.approach | 94 |
| abstract_inverted_index.disorder | 34 |
| abstract_inverted_index.episodes | 13 |
| abstract_inverted_index.evidence | 156 |
| abstract_inverted_index.focusing | 55 |
| abstract_inverted_index.molecule | 172 |
| abstract_inverted_index.neuronal | 129 |
| abstract_inverted_index.positive | 18 |
| abstract_inverted_index.promotes | 12 |
| abstract_inverted_index.specific | 101 |
| abstract_inverted_index.Comparing | 67 |
| abstract_inverted_index.affective | 19 |
| abstract_inverted_index.approach, | 136 |
| abstract_inverted_index.determine | 116 |
| abstract_inverted_index.generates | 17 |
| abstract_inverted_index.including | 31, 83 |
| abstract_inverted_index.knock-out | 106 |
| abstract_inverted_index.mediators | 51 |
| abstract_inverted_index.molecular | 38, 50 |
| abstract_inverted_index.phenotype | 191 |
| abstract_inverted_index.potential | 23, 143 |
| abstract_inverted_index.regulates | 9 |
| abstract_inverted_index.relevance | 118, 185 |
| abstract_inverted_index.signature | 171 |
| abstract_inverted_index.approaches | 181 |
| abstract_inverted_index.behavioral | 126 |
| abstract_inverted_index.considered | 175 |
| abstract_inverted_index.designated | 134 |
| abstract_inverted_index.disorders. | 196 |
| abstract_inverted_index.expression | 61, 163 |
| abstract_inverted_index.functional | 130 |
| abstract_inverted_index.identified | 141 |
| abstract_inverted_index.illnesses, | 30 |
| abstract_inverted_index.inhibitory | 6 |
| abstract_inverted_index.mechanism, | 7 |
| abstract_inverted_index.mechanisms | 39 |
| abstract_inverted_index.regulation | 159 |
| abstract_inverted_index.responses, | 11 |
| abstract_inverted_index.validated. | 151 |
| abstract_inverted_index.basolateral | 64 |
| abstract_inverted_index.depression, | 36 |
| abstract_inverted_index.identified. | 91 |
| abstract_inverted_index.miR-132/212 | 105 |
| abstract_inverted_index.preclinical | 178 |
| abstract_inverted_index.psychiatric | 29 |
| abstract_inverted_index.understood, | 45 |
| abstract_inverted_index.experimental | 25 |
| abstract_inverted_index.intermediate | 190 |
| abstract_inverted_index.investigated | 48 |
| abstract_inverted_index.miR-132/-212 | 88 |
| abstract_inverted_index.transfection | 98 |
| abstract_inverted_index.bioinformatic | 135 |
| abstract_inverted_index.translational | 180 |
| abstract_inverted_index.experimentally | 150 |
| abstract_inverted_index.post-traumatic | 32 |
| abstract_inverted_index.safety-related | 81 |
| abstract_inverted_index.stress-related | 195 |
| abstract_inverted_index.transdiagnostic | 184 |
| abstract_inverted_index.characterization | 58 |
| abstract_inverted_index.gain-of-function | 93 |
| abstract_inverted_index.loss-of-function | 109 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.71109005 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |