A Scalable and Versatile Synthesis of Oxime‐Based Hormone Dimers and Gels for Sustained Release Article Swipe

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Oxime Linker Steroid Hormone Chemistry Hydrolysis Click chemistry Combinatorial chemistry Steroid hormone Organic chemistry Biochemistry Computer science Operating system

Christopher Bennett , Joe Collins , Zeyun Xiao , Daniel Klinger , Luke A. Connal ·

YOU? · · 2017 · Open Access · · DOI: https://doi.org/10.1002/asia.201700288 · OA: W2605626168

Well‐defined steroid hormone dimers and organogels were produced via a facile and scalable synthesis using oxime click chemistry. The versatile synthetic procedure extends to a wide range of hormones and linker groups exemplified here through the synthesis of cortisol‐ and progesterone‐dimers linked via hydrophobic, hydrophilic or functional groups. This method was also extended to the synthesis of cortisone‐based organogels. Owing to the dynamic nature of the oxime bond, the hormone‐based materials are degradable via acidic hydrolysis and transoximination representing new materials for the controlled release of steroid hormones.