A Simulation of the Mechanical Testing of the Cell Membrane and Cytoskeleton Article Swipe
Yue Du
,
Dai Cheng
,
Zhanli Yang
,
Yaowei Liu
,
Qili Zhao
,
Mingzhu Sun
,
Haifeng Li
,
Xin Zhao
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/mi15040431
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/mi15040431
Cell models play a crucial role in analyzing the mechanical response of cells and quantifying cellular damage incurred during micromanipulation. While traditional models can capture the overall mechanical behavior of cells, they often lack the ability to discern among distinct cellular components. Consequently, by employing dissipative particle dynamics, this study constructed a triangular network-like representation of the cell membrane along with cross-linked cytoskeletal chains. The mechanical properties of both the membrane and cytoskeleton were then analyzed through a series of simulated mechanical tests, validated against real-world experiments. The investigation utilized particle-tracking rheology to monitor changes in the mean square displacements of membrane particles over time, facilitating the analysis of the membrane’s storage and loss moduli. Additionally, the cytoskeletal network’s storage and loss moduli were examined via a double-plate oscillatory shear experiment. The simulation results revealed that both the membrane and cytoskeleton exhibit viscoelastic behavior, as evidenced by the power-law dependency of their storage and loss moduli on frequency. Furthermore, indentation and microinjection simulations were conducted to examine the overall mechanical properties of cells. In the indentation experiments, an increase in the shear modulus of the membrane’s WLCs correlated with a higher Young’s modulus for the entire cell. Regarding the microinjection experiment, augmenting the microinjection speed resulted in reduced deformation of the cell at the point of membrane rupture and a lower percentage of high strain.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/mi15040431
- https://www.mdpi.com/2072-666X/15/4/431/pdf?version=1711377061
- OA Status
- gold
- Cited By
- 2
- References
- 39
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4393159292Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/mi15040431Digital Object Identifier
- Title
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A Simulation of the Mechanical Testing of the Cell Membrane and CytoskeletonWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-03-23Full publication date if available
- Authors
-
Yue Du, Dai Cheng, Zhanli Yang, Yaowei Liu, Qili Zhao, Mingzhu Sun, Haifeng Li, Xin ZhaoList of authors in order
- Landing page
-
https://doi.org/10.3390/mi15040431Publisher landing page
- PDF URL
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https://www.mdpi.com/2072-666X/15/4/431/pdf?version=1711377061Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2072-666X/15/4/431/pdf?version=1711377061Direct OA link when available
- Concepts
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Cytoskeleton, Membrane, Materials science, Cell, Chemistry, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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