A single-cell 3D dynamic volume control system for chondrocytes Article Swipe
Qiang Zhang
,
Yiyao Wang
,
Zuo‐Feng Zhang
,
Xiaochun Wei
,
Weiyi Chen
,
Quanyou Zhang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1080/07366205.2024.2412414
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1080/07366205.2024.2412414
In articular cartilage, zone-specific cellular morphology is a typical characteristic of cartilage tissue, which is related with chondrocyte function, inflammation and osteoarthritis (OA). Chondrocyte hypertrophic phenotype is a criticle physiological process which indicates a hallmark of chondrocyte terminal differentiation and bone formation. Thus, developing a in vitro cell culture system for dynamic regulation of single chondrocyte volume at a three-dimensional (3D) level is particularly necessary for understanding how physical cues of matrix microenvironment regulate chondrocyte fate and the degeneration of articular cartilage. Here, based on the soft lithography techniques, we have constructed well-defined single-cell 3D dynamic volume control system to recapitulate the physiological matrix microenvironment of single chondrocyte niche. The results of finite element analysis indicated that the stress and strain distribution in the cell culture region is homogeneous during the stretching process. Additionally, 3D dynamic volume expansion and compression of single cells in physiological or hyperphysiological can be realized in this cell culture system. Our device for single-cell 3D dynamic culture provides a microphysiological culture system for chondrocytes to explore the mechanisms of cartilage hypertrophy, as well as develops a new paradigm for functional cartilage tissue engineering and regenerative medicine.
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- en
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- https://doi.org/10.1080/07366205.2024.2412414
- OA Status
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All OpenAlex metadata
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https://openalex.org/W4403406567Canonical identifier for this work in OpenAlex
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https://doi.org/10.1080/07366205.2024.2412414Digital Object Identifier
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A single-cell 3D dynamic volume control system for chondrocytesWork title
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articleOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-10-15Full publication date if available
- Authors
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Qiang Zhang, Yiyao Wang, Zuo‐Feng Zhang, Xiaochun Wei, Weiyi Chen, Quanyou ZhangList of authors in order
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https://doi.org/10.1080/07366205.2024.2412414Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1080/07366205.2024.2412414Direct OA link when available
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Volume (thermodynamics), Computational biology, Biology, Cell biology, Cell, Chemistry, Computer science, Genetics, Physics, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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